ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Yakugaku Zasshi.2018 Jan 30;Advance Publication2015 Aug 18Mol Med Rep.2014 May;9(5):1653-9.Pharmacological Reports31 May 2017BMC Complement Altern Med.2016 Jul 13
Mediators Inflamm. 2016;2016:6189590.Anal Bioanal Chem. 2016 Jun;408(15)Inflammation.2015 Feb;38(1):445-55. J Sci Food Agric. 2017 Jul 22. J Nat Med.2017 Apr
Korean J. of Horticultural Sci. & Tech. No.2, 2017.2Int J Mol Sci.2015 Jan 6;16(1):1232-51.Biomed Chromatogr. 2016 Mar 23.Food Science and Bio.31 October 2016
Our products had been exported to the following research institutions and universities, And still growing.
Wageningen University (Netherlands)The Vancouver Prostate Centre (V... (Canada)Yale University (USA)Universidad Industrial de Santan... (Colombia)
University of Sao Paulo (Brazil)Universidade do Porto (Portugal)University of Liège (Belgium)University of Hertfordshire (United Kingdom)
Chulalongkorn University (Thailand)Chang Gung University (Taiwan)Heinrich-Heine-University Düsse... (Germany)
||Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).|
|Fitoterapia. 2012 Jul;83(5):864-71. |
|Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.[Pubmed: 22465508]|
METHODS AND RESULTS:
Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and Isocurcumenol (6) were isolated from rhizomes of Curcuma aeruginosa Roxb. (Zingiberaceae). They inhibited 5α-reductase which converts testosterone to dihydrotestosterone (DHT). Germacrone (1) was the most potent (IC(50)=0.42±0.05 mg/mL). Compound 1 was anti-androgenic in LNCaP cells when proliferation was testosterone-induced. The growth of flank gland of male Syrian hamsters is dependent on circulating androgen and when maintained with testosterone, 1 (3, 30, 100μg) inhibited growth but was ineffective against DHT. The similar activity profile was observed on the 5α-reductase inhibitor, finasteride (100 μg) treatment group. The androgen receptor binding assay showed that 1 did not bind to the androgen receptor.
In conclusion, 1 showed anti-androgenic effect on in vitro and in vivo assays. One of the possible mechanisms was inhibition 5α-reductase activity. Thus, 1 is a potential lead compound for treatment of androgen-dependent disorders.
||The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Nat Prod Res. 2014;28(20):1680-4. |
|Comparative study on the chemical constituents of essential oils from different organs of the Sicilian Kundmannia (Kundmannia sicula L.) DC. (Apiaceae) growing spontaneously in Tunisia.[Pubmed: 25022439]|
|Essential oils from odorous and volatile compounds possessing several therapeutic benefits are considered of a paramount importance in everyday human life.
METHODS AND RESULTS:
This study deals with a comparative study of essential oils from different parts of an aromatic plant Kundmannia sicula (L.) DC. (Apiaceae) growing in Tunisia. The hydro-distilled essential oils of the leaves and inflorescences with mature seeds (IMS) of K. sicula were analysed for the first time by gas chromatography equipped with flame ionisation detector and gas chromatography coupled with mass spectrometry. Fifty leaves and 47 IMS constituents were identified, accounting for 97.9% and 98.2% of the total oil, respectively.
The major compounds identified from the leaves and IMS oils were Isocurcumenol (9.9-10.1%), hexadecanoic acid (9.5-10.9%), spathulenol (6.9-3.4%), 10-epi-γ-eudesmol (6.3-5.5%), α-cubebene (5.9-6.1%) and trans-dihydro occidentalol (52-6.6%). The essential oil consists mainly of oxygenated monoterpenes (50.7-53.2%).