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    Isomangiferin
    Information
    CAS No. 24699-16-9 Price $228 / 10mg
    Catalog No.CFN90385Purity>=98%
    Molecular Weight422.34Type of CompoundXanthones
    FormulaC19H18O11Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Isomangiferin has antioxidant and radical-scavenging activities; it also has antiviral effect, may due to its capability of inhibiting virus replication within cells.
    Targets: HSV
    In vitro:
    Zhongguo Yao Li Xue Bao. 1989 Jan;10(1):85-90.
    Antiviral effect of mangiferin and isomangiferin on herpes simplex virus[Pubmed: 2554669]

    METHODS AND RESULTS:
    Using tissue culture techniques the present study assured us of the merits of mangiferin and Isomangiferin in the antiviral action against HSV-1. Utilizing 4 main patterns for evaluating drug effectiveness (ie intratube drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by logarithm determination of HSV-I inhibition that Isomangiferin was superior to such control drugs as acyclovir, idoxuridine, and cyclocytidine in logarithm by 0.27-0.50, and that mangiferin was lower than Isomangiferin in logarithm by 0.53. The average plaque reduction rates of mangiferin and Isomangiferin were 69.5% and 56.8%, respectively.
    CONCLUSIONS:
    All in all, the antiviral effect of mangiferin and Isomangiferin was attributed presumably to their capability to inhibit virus replication within cells.
    J Nat Prod. 2008 Nov;71(11):1887-90.
    Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.[Pubmed: 18950229]

    METHODS AND RESULTS:
    Chemical investigation of the methanol extract from the leaves of Arrabidaea patellifera, a Bignoniaceae from Panama, afforded mangiferin, Isomangiferin, and six new derivatives (3'-O-p-hydroxybenzoylmangiferin, 3'-O-trans-coumaroylmangiferin, 6'-O-trans-coumaroylmangiferin, 3'-O-trans-cinnamoylmangiferin, 3'-O-trans-caffeoylmangiferin, and 3'-O-benzoylmangiferin). All these compounds had antioxidant and radical-scavenging activities, and four of them were relatively active in vitro against Plasmodium falciparum.
    CONCLUSIONS:
    The structures were determined by spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.
    Isomangiferin Description
    Source: The herbs of Mangifera indica L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    PMID: 29230013

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    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3678 mL 11.8388 mL 23.6776 mL 47.3552 mL 59.194 mL
    5 mM 0.4736 mL 2.3678 mL 4.7355 mL 9.471 mL 11.8388 mL
    10 mM 0.2368 mL 1.1839 mL 2.3678 mL 4.7355 mL 5.9194 mL
    50 mM 0.0474 mL 0.2368 mL 0.4736 mL 0.9471 mL 1.1839 mL
    100 mM 0.0237 mL 0.1184 mL 0.2368 mL 0.4736 mL 0.5919 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Eur. Food Res.Technol., 2003, 216(3):270-3.
    Reversed-phase HPLC determination of mangiferin, isomangiferin and hesperidin in Cyclopia and the effect of harvesting date on the phenolic composition of C. genistoides[Reference: WebLink]
    A reversed-phase HPLC method for separation of polyphenols in honeybush tea (Cyclopia spp.) is presented. Separation of eriodictyol, luteolin, medicagol, formononetin, mangiferin, Isomangiferin, hesperetin and hesperidin was investigated. A C12 stationary phase was required to separate mangiferin and Isomangiferin.
    METHODS AND RESULTS:
    The method was used to quantify the three major polyphenols (mangiferin, Isomangiferin and hesperidin) in C. genistoides, C. intermedia, C. maculata and C. sessiliflora and to study the effect of harvesting date on these compounds in two types of C. genistoides. The highest levels of the xanthones, mangiferin (3.61 g/100 g) and Isomangiferin (0.54 g/100 g), and the flavanone, hesperidin (1.74 g/100 g), were found for C. genistoides (both xanthones) and C. intermedia, respectively. Cyclopia sessiliflora contained the lowest levels of mangiferin (1.04 g/100 g) and hesperidin (0.29 g/100 g). The mangiferin content of both the Overberg and West Coast types decreased with harvesting date (P <0.05).
    CONCLUSIONS:
    The Overberg type contained more mangiferin, but hesperidin was more prominent in the West Coast type.