ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $303.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Nat Prod Commun.2014, 9(5):679-82Molecules.2016, 21(6)Int J Mol Med.2016, 37(2):501-8Int J Oncol.2016, 49(4):1497-504Food Analytical Methods...2017...FEMS Microbiol Lett.2017, 364(11)Universidade Estadual Paulista...2017...Cytotechnology.2017, 69(5):765-773
Pharmacol Rep.2017, 69(6):1224-1231Sci Rep. 2017, 8207(7)Nutrients.2018, 11(1):E17Evid Based Complement Alternat Me...2018...South African J of Plant&Soil...2018...Asian Journal of Chemistry...2018...Toxicol In Vitro.2018, 52:94-105Pathogens.2018, 7(3):E62
J Chromatogr B Analyt Technol Bio...2019...Pak J Pharm Sci.2019, 32(6):2879-2885Process Biochemistry2019, 87:213-220Genes Genomics.2020, 10.1007Food Res Int.2020, 128:108778Drug Des Devel Ther.2020, 14:61-71Industrial Crops and Products...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Regional Crop Research Institute (Korea)St. Jude Children Research Hosp... (USA)Utah State University (USA)Korea Food Research Institute(K... (Korea)
University of Pretoria (South Africa)S.N.D.T. Women's University (India)University of Medicine and Phar... (Romania)Universidad Miguel Hernández (Spain)
Center for protein Engineering ... (Belgium)University of Maryland (USA)University of South Australia (Australia)
Related Screening Libraries
|| Methylnissolin is a natural product from A. membranaceus.|
||TNF-α | IL Receptor|
|Arch Pharm Res. 2014 Feb;37(2):186-92. |
|Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed: 23771500 ]|
|Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms.|
METHODS AND RESULTS:
In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5), formononetin 7-O-β-D-glucoside (6), daidzein (7), daidzein 7-O-β-D-glucoside (8), Methylnissolin (9), Methylnissolin 3-O-β-D-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-β-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM.
Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.
||The herbs of Astragalus sinicus L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.