ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
BMC Complement Altern Med.2014 Jul 14;14:242.British Jou. Med. & Med. Research2014 Jan 1BMC Pharmacol Toxicol. 2018 Jan 31;Molecules 2016, 21(6), 780; 2016 Jun 17;21(6).J Biochem Mol Toxicol. 2017 Jun 7
J. Soc. Cosmet. Sci. KoreaJune 2016Am J Chin Med.2016;44(6)Biochem Biophys Res Commun. 2017 Dec 16;BMC Complement Altern Med.2017 Aug 3;Arch Pharm Res.2014 Oct 18.
J Ethnopharmacol. 2017 Feb 23;Molecules 2016, 21(6), 739;2016 Jun 14;21(6). Phytomedicine1 March 2018;BMC Complement Altern Med.2014 Sep 23;14:352.
Our products had been exported to the following research institutions and universities, And still growing.
University of Indonesia (Indonesia)University of Maryland (USA)University of Helsinki (Finland)University of Lodz (Poland)
University of Medicine and Pharm... (Romania)Technical University of Denmark (Denmark)Shanghai University of TCM (China)Universidad de La Salle (Mexico)
Institute of Bioorganic Chemistr... (Poland)Universidade Federal de Santa Ca... (Brazil)Vin?a Institute of Nuclear Scien... (Serbia)
||Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. |
Moracin M Description
||The root barks of Morus alba L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. |
|Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586]|
|Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. |
METHODS AND RESULTS:
Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.