|Source:||The root bark of Morus alba L.|
|Biological Activity or Inhibitors:||1. Moracin M is a phytoalexin.
2. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||4.1288 mL||20.6441 mL||41.2882 mL||82.5764 mL||103.2205 mL|
|5 mM||0.8258 mL||4.1288 mL||8.2576 mL||16.5153 mL||20.6441 mL|
|10 mM||0.4129 mL||2.0644 mL||4.1288 mL||8.2576 mL||10.322 mL|
|50 mM||0.0826 mL||0.4129 mL||0.8258 mL||1.6515 mL||2.0644 mL|
|100 mM||0.0413 mL||0.2064 mL||0.4129 mL||0.8258 mL||1.0322 mL|
Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.
|Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586]|
|Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.|