ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
How to Order
Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
J Agric Food Chem.2016 Sep 7Inflammation. 2015 Feb 6.Faculty of Chem. & Nat. Resource Eng.Jul. 2014International Journal of Pharmacognosy.2015 7(1).Arch Biochem Biophys. 2018 Jan 15;
University of Central Lancashire2017;BMC Complement Altern Med.2014 Sep 23;14:352.RSC AdvancesIssue 86, 2017Acta Biochim Pol.2015 May 26Front Pharmacol. 2016 Nov 30
J Ethnopharmacol. 2017 Jul 12;J Ethnopharmacol. 2017 Jul 12;Hindawi Publishing Corporation2015 July 30Phytomedicine1 March 2018;
Our products had been exported to the following research institutions and universities, And still growing.
Martin Luther University of Hall... (Germany)Universita' Degli Studi Di Cagli... (Italy)University of Queensland (Australia)University of Illinois at Chicago (USA)
National Cancer Center Research ... (Japan)Florida A&M University (USA)Universidade Católica Portuguesa (Portugal)Massachusetts General Hospital (USA)
Aarhus University (Denmark)Universidad Industrial de Santan... (Colombia)Universiti Sains Malaysia (Malaysia)
Moracin M Description
||The root bark of Morus alba L.
|Biological Activity or Inhibitors:
||1. Moracin M is a phytoalexin.
2. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Moracin M References Information
Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.
|Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed: 22483586]|
|Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.