• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Berberine hydrochloride
    Information
    CAS No. 633-65-8 Price $30 / 20mg
    Catalog No.CFN99562Purity>=98%
    Molecular Weight371.81Type of CompoundAlkaloids
    FormulaC20H18NO4ClPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universiti Kebangsaan Malaysia (Malaysia)
  • The Vancouver Prostate Centre (V... (Canada)
  • University of Amsterdam (Netherlands)
  • Kyoto University (Japan)
  • Universidad de Antioquia (Colombia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Stirling (United Kingdom)
  • Kyushu University (Japan)
  • Sanford Burnham Prebys Medical D... (USA)
  • University of Brasilia (Brazil)
  • Wageningen University (Netherlands)
  • More...
  • Package
    Featured Products
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Linderane

    Catalog No: CFN98175
    CAS No: 13476-25-0
    Price: $138/20mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $413/5mg
    Pyrocurzerenone

    Catalog No: CFN96169
    CAS No: 20013-75-6
    Price: $388/20mg
    Polygalaxanthone III

    Catalog No: CFN90208
    CAS No: 162857-78-5
    Price: $138/20mg
    Biological Activity
    Description: Berberine hydrochloride has anticancer, antifungi, anti-inflammatory, and anti-oxidant activities, it can significantly attenuate neutrophil infiltration, suppress myeloperoxidase activity, decrease NO, TNF-αand IL-1βproduction, inhibits the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα.
    Targets: NO | TNF-α | IL Receptor | NF-kB | p65 | IkB | JNK | IKK
    In vitro:
    Journal of Medicinal Plant Research, 2011 , 5 (16) :3702-7.
    Antioxidant activities of berberine hydrochloride[Reference: WebLink]
    In order to explore the mechanism of Berberine hydrochloride in treating diabetes, antioxidant activities of the Berberine hydrochloride in vitro were carried out.
    METHODS AND RESULTS:
    In the present study, our study aimed to examine the antioxidant activity of Berberine hydrochloride using different assays including: reducing power, 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging assay, ABTS radical scavenging assay, superoxide anion and hydroxyl radical scavenging activity.
    CONCLUSIONS:
    The results exhibited that Berberine hydrochloride has significant reductive ability and radicals scavenging effects, especially on ABTS, hydroxyl radicals and DPPH radicals.
    Int J Nanomedicine. 2011;6:1773-7.
    Berberine hydrochloride: anticancer activity and nanoparticulate delivery system.[Pubmed: 21931477 ]
    Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of Berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of Berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine.
    METHODS AND RESULTS:
    We accessed conventional databases, such as PubMed, Scope, and Web of Science, using "Berberine hydrochloride", "anti-cancer mechanism", and "nanoparticulate delivery system" as search words, then summarized the progress in research, illustrating the need to explore reprogramming of cancer cell metabolism using nanoparticulate drug delivery systems.
    CONCLUSIONS:
    With increasing research on regulation of cancer cell metabolism by Berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, Berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of Berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation.
    J Prosthet Dent. 1990 Dec;64(6):691-4.
    Effects of crude drugs and berberine hydrochloride on the activities of fungi.[Pubmed: 2079677]
    The effects of crude drugs on fungi have been used for a thousand years in China and Japan. These drugs include: Saussureae radix, Magnoliae cortex, Cinnamomi cortex, Hydrangeae dulcis folium, and Artemisiae capillarius flos. The activity of Coptidis rhizoma and Phellodendri cortex was stronger than other crude drugs against the three fungi.
    METHODS AND RESULTS:
    Berberine hydrochloride, which is a component of the two crude drugs, was investigated. Minimal inhibitory concentration values of Berberine hydrochloride were 1, 0.125, and 0.5 mg/ml against Candida albicans, C. tropicalis, and C. glabrata, respectively.
    CONCLUSIONS:
    In C. glabrata, compared with C. albicans and C. tropicalis, Berberine hydrochloride greatly inhibited the growth of fungi.
    In vivo:
    Int Immunopharmacol. 2015 Jan;24(1):128-32.
    Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway.[Pubmed: 25479718]
    Endometritis is a common disease in animal production and influences breeding all over the world. Berberine is one of the main alkaloids isolated from Rhizoma coptidis. Previous reports showed that berberine has anti-inflammatory potential. However, there have been a limited number of published reports on the anti-inflammatory effect of Berberine hydrochloride on LPS-induced endometritis. The purpose of the present study was to investigate the effects of Berberine hydrochloride on LPS-induced mouse endometritis.
    METHODS AND RESULTS:
    Berberine hydrochloride was administered intraperitoneally at 1h before and 12h after LPS induction. Then, a biopsy was performed, and uterine myeloperoxidase (MPO) and nitric oxide (NO) concentrations were determined. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels in the uterus homogenate were measured by ELISA. The extent of IκB-α and P65 phosphorylation was detected by Western blot. The results showed that Berberine hydrochloride significantly attenuated neutrophil infiltration, suppressed myeloperoxidase activity and decreased NO, TNF-αand IL-1βproduction. Furthermore, Berberine hydrochloride inhibited the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα.
    CONCLUSIONS:
    These findings suggest that Berberine hydrochloride exerts potent anti-inflammatory effects on LPS-induced mouse endometritis and might be a potential therapeutic agent for endometritis.
    Berberine hydrochloride Description
    Source: The herbs of Coptis chinensis Franch.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Iridin

    Catalog No: CFN96557
    CAS No: 491-74-7
    Price: $188/20mg
    9-O-Acetyl-fargesol

    Catalog No: CFN95031
    CAS No: 449172-61-6
    Price: $413/5mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    3'-Angeloyloxy-4'-senecioyloxy-2',...

    Catalog No: CFN95123
    CAS No: 1221686-60-7
    Price: $398/5mg
    1-Methoxycarbonyl-beta-carboline

    Catalog No: CFN98456
    CAS No: 3464-66-2
    Price: $288/5mg
    Dihydrolicoisoflavone

    Catalog No: CFN95073
    CAS No: 164163-92-2
    Price: $333/5mg
    Atractylenolide III acetate

    Catalog No: CFN95078
    CAS No: N/A
    Price: $413/5mg
    Poricoic acid A(F)

    Catalog No: CFN92838
    CAS No: 137551-38-3
    Price: $218/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6895 mL 13.4477 mL 26.8955 mL 53.7909 mL 67.2386 mL
    5 mM 0.5379 mL 2.6895 mL 5.3791 mL 10.7582 mL 13.4477 mL
    10 mM 0.269 mL 1.3448 mL 2.6895 mL 5.3791 mL 6.7239 mL
    50 mM 0.0538 mL 0.269 mL 0.5379 mL 1.0758 mL 1.3448 mL
    100 mM 0.0269 mL 0.1345 mL 0.269 mL 0.5379 mL 0.6724 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    J Pharmacol Exp Ther. 2014 Jun;349(3):417-26.
    Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats.[Pubmed: 24676878]
    Intestinal adhesion, characterized by connection of the loops of the intestine with other abdominal organs by fibrous tissue bands, remains an inevitable event of abdominal operations and can cause a number of complications. Berberine hydrochloride (berberine), a natural plant alkaloid derived from Chinese herbal medicine, is characterized by diverse pharmacological effects, such as anticancer and lower elevated blood glucose. This study is designed to investigate the effects of berberine on adhesion and inflammation after abdominal surgeries and the underlying molecular mechanisms.
    METHODS AND RESULTS:
    Adhesion severity grades and collagen deposition were assessed 14 days after surgery. We evaluated the levels of intercellular adhesion molecule-1 (ICAM-1) and inflammatory cytokines interleukin-1β (IL-1β), IL-6, transforming growth factor β (TGF-β), tumor necrosis factor-α (TNF-α), and examined transforming growth factor-activated kinase 1 (TAK1)/c-Jun N-terminal kinase (JNK) and TAK1/nuclear factor κB (NF-κB) signaling. The surgery group experienced the most severe adhesions, and berberine strikingly reduced the density and severity of adhesion. Results showed significant lower expression of IL-1β, IL-6, TGF-β, TNF-α, and ICAM-1, in berberine groups compared with the operation group. Activities of phosphorylated JNK and phosphorylated NF-κB were inhibited in the berberine groups compared with the surgery group.
    CONCLUSIONS:
    Our novel findings identified Berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-κB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.