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    Berberine hydrochloride
    Information
    CAS No. 633-65-8 Price $30 / 20mg
    Catalog No.CFN99562Purity>=98%
    Molecular Weight371.81Type of CompoundAlkaloids
    FormulaC20H18NO4ClPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Berberine hydrochloride is characterized by a diversity of pharmacological effects, has anticancer activity and the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever.
    2. Berberine hydrochloride has antifungi activity.
    3. Berberine hydrochloride has significant reductive ability and radicals scavenging effects, especially on ABTS, hydroxyl radicals and DPPH radicals.
    4. Berberine hydrochloride can significantly attenuate neutrophil infiltration, suppress myeloperoxidase activity, decrease NO, TNF-αand IL-1βproduction, inhibits the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα, thus, exerts potent anti-inflammatory effects on LPS-induced mouse endometritis.
    5. Berberine hydrochloride can prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-κB signaling after abdominal surgery, which brings out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.
    Targets: NO | TNF-α | IL Receptor | NF-kB | p65 | IkB | JNK | IKK
    Berberine hydrochloride Description
    Source: The herb of Coptis chinensis Franch.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6895 mL 13.4477 mL 26.8955 mL 53.7909 mL 67.2386 mL
    5 mM 0.5379 mL 2.6895 mL 5.3791 mL 10.7582 mL 13.4477 mL
    10 mM 0.269 mL 1.3448 mL 2.6895 mL 5.3791 mL 6.7239 mL
    50 mM 0.0538 mL 0.269 mL 0.5379 mL 1.0758 mL 1.3448 mL
    100 mM 0.0269 mL 0.1345 mL 0.269 mL 0.5379 mL 0.6724 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Berberine hydrochloride References Information
    Citation [1]

    Journal of Medicinal Plant Research, 2011 , 5 (16) :3702-7.

    Antioxidant activities of berberine hydrochloride[Reference: WebLink]
    In order to explore the mechanism of Berberine hydrochloride in treating diabetes, antioxidant activities of the Berberine hydrochloride in vitro were carried out. In the present study, our study aimed to examine the antioxidant activity of Berberine hydrochloride using different assays including: reducing power, 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging assay, ABTS radical scavenging assay, superoxide anion and hydroxyl radical scavenging activity. The results exhibited that Berberine hydrochloride has significant reductive ability and radicals scavenging effects, especially on ABTS, hydroxyl radicals and DPPH radicals. Key words: Berberine hydrochloride, antioxidant activity, free radicals, in vitro.
    Citation [2]

    J Pharmacol Exp Ther. 2014 Jun;349(3):417-26.

    Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats.[Pubmed: 24676878]
    Intestinal adhesion, characterized by connection of the loops of the intestine with other abdominal organs by fibrous tissue bands, remains an inevitable event of abdominal operations and can cause a number of complications. Berberine hydrochloride (berberine), a natural plant alkaloid derived from Chinese herbal medicine, is characterized by diverse pharmacological effects, such as anticancer and lower elevated blood glucose. This study is designed to investigate the effects of berberine on adhesion and inflammation after abdominal surgeries and the underlying molecular mechanisms. Adhesion severity grades and collagen deposition were assessed 14 days after surgery. We evaluated the levels of intercellular adhesion molecule-1 (ICAM-1) and inflammatory cytokines interleukin-1β (IL-1β), IL-6, transforming growth factor β (TGF-β), tumor necrosis factor-α (TNF-α), and examined transforming growth factor-activated kinase 1 (TAK1)/c-Jun N-terminal kinase (JNK) and TAK1/nuclear factor κB (NF-κB) signaling. The surgery group experienced the most severe adhesions, and berberine strikingly reduced the density and severity of adhesion. Results showed significant lower expression of IL-1β, IL-6, TGF-β, TNF-α, and ICAM-1, in berberine groups compared with the operation group. Activities of phosphorylated JNK and phosphorylated NF-κB were inhibited in the berberine groups compared with the surgery group. Our novel findings identified Berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-κB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.
    Citation [3]

    Int J Nanomedicine. 2011;6:1773-7.

    Berberine hydrochloride: anticancer activity and nanoparticulate delivery system.[Pubmed: 21931477 ]
    Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of Berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of Berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine.
    Citation [4]

    Int Immunopharmacol. 2015 Jan;24(1):128-32.

    Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway.[Pubmed: 25479718]
    Endometritis is a common disease in animal production and influences breeding all over the world. Berberine is one of the main alkaloids isolated from Rhizoma coptidis. Previous reports showed that berberine has anti-inflammatory potential. However, there have been a limited number of published reports on the anti-inflammatory effect of Berberine hydrochloride on LPS-induced endometritis. The purpose of the present study was to investigate the effects of Berberine hydrochloride on LPS-induced mouse endometritis. Berberine hydrochloride was administered intraperitoneally at 1h before and 12h after LPS induction. Then, a biopsy was performed, and uterine myeloperoxidase (MPO) and nitric oxide (NO) concentrations were determined. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels in the uterus homogenate were measured by ELISA. The extent of IκB-α and P65 phosphorylation was detected by Western blot. The results showed that Berberine hydrochloride significantly attenuated neutrophil infiltration, suppressed myeloperoxidase activity and decreased NO, TNF-αand IL-1βproduction. Furthermore, Berberine hydrochloride inhibited the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα. These findings suggest that Berberine hydrochloride exerts potent anti-inflammatory effects on LPS-induced mouse endometritis and might be a potential therapeutic agent for endometritis.
    Citation [5]

    J Prosthet Dent. 1990 Dec;64(6):691-4.

    Effects of crude drugs and berberine hydrochloride on the activities of fungi.[Pubmed: CFN99562]
    The effects of crude drugs on fungi have been used for a thousand years in China and Japan. These drugs include: Saussureae radix, Magnoliae cortex, Cinnamomi cortex, Hydrangeae dulcis folium, and Artemisiae capillarius flos. The activity of Coptidis rhizoma and Phellodendri cortex was stronger than other crude drugs against the three fungi. Berberine hydrochloride, which is a component of the two crude drugs, was investigated. Minimal inhibitory concentration values of Berberine hydrochloride were 1, 0.125, and 0.5 mg/ml against Candida albicans, C. tropicalis, and C. glabrata, respectively. In C. glabrata, compared with C. albicans and C. tropicalis, Berberine hydrochloride greatly inhibited the growth of fungi.