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    CAS No. 94079-81-9 Price $208 / 20mg
    Catalog No.CFN99714Purity>=98%
    Molecular Weight770.73Type of CompoundPhenylpropanoids
    FormulaC35H46O19Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $116.3 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • University of Hertfordshire (United Kingdom)
  • Korea Intitute of Science and T... (Korea)
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  • Biological Activity
    Description: Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumoside has oxidant scavenging, antibacterial and hemostasis capacities, it can inhibit Biofilm-forming Staphylococcus aureus in mice.
    Targets: Antifection | Lens aldose reductase
    In vitro:
    Biol Pharm Bull. 2009 Dec;32(12):1952-6.
    Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis.[Pubmed: 19952410]

    Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); Poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of Buddleja officinalis MAXIM. (Buddlejaceae). Chemical structures were confirmed by (1)H-, and (13)C-NMR, and MS spectral methods and compared with those reported in the literature. Antioxidant activities of the methanol and water extracts, and all isolated compounds were evaluated using the total oxidant scavenging capacity (TOSC) assay against peroxynitrite.
    Results of the assay showed that the phenylethanoid glycosides, a major class of compounds of the flowers of B. officinalis, possess strong antioxidant activity. Of these, acteoside, echinacoside and Poliumoside have 9.9-, 9.8- and 9.5-fold TOSC value, respectively, compared with the positive control, Trolox.
    Planta Med. 2013 Dec;79(18):1705-9.
    Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit advanced glycation end product formation and aldose reductase in vitro and vessel dilation in larval zebrafish in vivo.[Pubmed: 24288293]
    In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), Poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-5) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation and rat lens aldose reductase activity.
    All tested compounds exhibited significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM, compared with those of aminoguanidine (IC50=1,056 μM) and quercetin (IC50=28.4 μM) as positive controls. In the rat lens aldose reductase assay, acteoside, isoacteoside, and Poliumoside exhibited greater inhibitory effects on rat lens aldose reductase with IC50 values of 0.83, 0.83, and 0.85 μM, respectively, than those of the positive controls, 3,3-tetramethyleneglutaric acid (IC50=4.03 μM) and quercetin (IC50=7.2 μM). In addition, the effect of acteoside on the dilation of hyaloid-retinal vessels induced by high glucose in larval zebrafish was investigated. Acteoside reduced the diameters of high glucose-induced hyaloid-retinal vessels by 69% at 10 μM and 81% at 20 μM, compared to the high glucose-treated control group.
    These results suggest that B. hancei and its active components might be beneficial in the treatment and prevention of diabetic vascular complications.
    In vivo:
    International Eurasia Pharmacy Congress. 2015, 9.
    Poliumoside from Teucrium polium Inhibit Biofilm-forming Staphylococcus aureus in Mice.[Reference: WebLink]
    Previous studies have demonstrated the therapeutic efficacy of Teucrium species, family Lamiaceae, as antibacterial. T. polium has been used for wound healing and the extract has shown a marked antibacterial activity against both Gram-positive and Gram-negative bacteria.
    The focus of this study was to mine for T. polium secondary metabolites with antibiotic activity against the biofilm forming S. aureus. Purification and structural elucidation were based on chromatographic and spectroscopic IR, UV, 1D and 2D NMR, and ESI-MS data analysis. The stereochemistry was established by X-ray crystallography and modified Mosher’s method. Antibacterial activity was assessed based on Biofilm Inhibition Assay and confocal laser scanning microscopy. Four new sesquiterpenes together with twelve known were characterized. Antibacterial activity of three metabolites was observed in μMol range against biofilm forming S. aureus.
    In vivo study using mice, Poliumoside inhibited the biofilm forming S. aureus infections. The potential application of these compounds is preventing biofilm development by coating susceptible surfaces such as urinary and/or intravenous catheters, or dental sealing.
    Poliumoside Description
    Source: The herbs of Callicarpa dichotoma
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    Nature Plants. 2016 Dec 22;3: 16206.
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    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2975 mL 6.4874 mL 12.9747 mL 25.9494 mL 32.4368 mL
    5 mM 0.2595 mL 1.2975 mL 2.5949 mL 5.1899 mL 6.4874 mL
    10 mM 0.1297 mL 0.6487 mL 1.2975 mL 2.5949 mL 3.2437 mL
    50 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.519 mL 0.6487 mL
    100 mM 0.013 mL 0.0649 mL 0.1297 mL 0.2595 mL 0.3244 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Structure Identification:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:285-96.
    Identification of poliumoside metabolites in rat feces by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.[Pubmed: 25215644]
    Poliumoside is one of the major phenylethanoid glycosides (PhGs) isolated from Callicarpae Caulis et Folium (CCF) which is a traditional Chinese medicine used for hemostasis in clinic.
    In this study, high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC/Q-TOF-MS) was applied to investigate the metabolites of Poliumoside in rat feces after oral administration. A total of 66 metabolites were confirmed or tentatively identified. Poliumoside could be partly transformed into its positional isomer isoPoliumoside in vivo, and Poliumoside was easily hydrolyzed and metabolized into degradation products. The parent compound and its degradation products could further undergo extensive phase I and phase II metabolism.
    The results indicated that hydrolysis, hydroxylation, acetylation, sulfation, hydration, reduction, dehydrogenation and dimethylation were the major metabolic pathways of Poliumoside. The major metabolic soft spots of Poliumoside and the fragmentation patterns of the metabolites were also proposed. This study provided valuable information regarding the metabolites of Poliumoside in rats.