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    Polyphyllin VI
    Information
    CAS No. 55916-51-3 Price $178 / 20mg
    Catalog No.CFN99954Purity>=98%
    Molecular Weight738.91Type of CompoundSteroids
    FormulaC39H62O13Physical DescriptionWhite cryst.
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Stirling (United Kingdom)
  • University of Maryland (USA)
  • The Ohio State University (USA)
  • Siksha O Anusandhan University (India)
  • CSIRO - Agriculture Flagship (Australia)
  • Chang Gung University (Taiwan)
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    Biological Activity
    Description: Polyphyllin VI and polyphyllin VII possess anti-cancer activities, they exhibits strong inhibitory effects on lung cancer cell growth in vitro and in vivo by inducing G2/M cell cycle arrest and triggering apoptosis.
    Targets: p53 | PARP | Caspase
    In vitro:
    Phytother Res. 2015 Oct;29(10):1568-76.
    Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo.[Pubmed: 26272214]
    Polyphyllin VI (PVI) and Polyphyllin VII (PVII) derived from Paris polyphylla possess anti-cancer activities. However, the mechanisms for the anti-lung cancer effects of PVI and PVII remain poorly understood.
    METHODS AND RESULTS:
    In this study, PVI and PVII exhibited inhibitory effects on the proliferation of A549 and NCI-H1299 cells. PVI and PVII induced G2/M cell cycle arrest and triggered apoptosis. PVI and PVII upregulated the tumor suppressor protein p53 and downregulated cyclin B1. The two treatments significantly increased the expression levels of death receptor 3, death receptor 5, Fas, cleaved PARP, and cleaved caspase-3. Furthermore, PVI and PVII significantly inhibited the growth of A549 cells in vivo. The tumor inhibitory rates of PVI were 25.74%, 34.62%, and 40.43% at 2, 3, and 4 mg/kg, respectively, and those of PVII were 25.63%, 41.71%, and 40.41% at 1, 2, and 3 mg/kg, respectively. Finally, PVI and PVII regulated the expression of proteins related to the apoptotic pathway in A549 xenografts.
    CONCLUSIONS:
    In summary, PVI and PVII exhibited strong inhibitory effects on lung cancer cell growth in vitro and in vivo by inducing G2/M cell cycle arrest and triggering apoptosis.
    In vivo:
    World Chinese Journal of Digestology, 2014, 22(29):4393.
    Polyphyllin VI inhibits colitis associated colorectal carcinogenesis in mice: Possible mechanisms[Reference: WebLink]
    To investigate the effect of Polyphyllin VI(PPLⅥ) on colitis associated colorectal carcinogenesis in mice and the underlying mechanisms.
    METHODS AND RESULTS:
    Fifty male Institute of Cancer Research(ICR) mice were randomly divided into five groups: a model group, three PPLⅥ-treated groups and a control group. The mice in the model group and three PPLⅥ-treated groups were given a single intraperitoneal injection of 1,2-dimethylhydrazine(DMH) at a dose of 15 mg/kg body weight. One week later, the mice were treated with 2%(w/v) dextran sodium sulfate(DSS) in theirdrinking water for 1 wk. This was followed by no further treatment for 1 wk. After another 1 wk of 2% DSS treatment, normal water was given for an additional 15 weeks. At week 9, the mice in PPLⅥ-treated groups were intraperitoneally injected with PPLⅥ(2.5, 5.0 and 10.0 mg/kg, respectively) every 3 d, for 12 wk. All mice were sacrificed at week 20 by ether overdose and colon samples were collected for histopathological examinations and Western blot analysis. HE staining showed that the incidence of tumor formation was 90% in the mice treated with DMH/DSS; it decreased to 40%(4/10), 20%(2/10), and 10%(1/10) in mice treated with DMH/DSS plus 2.5, 5.0 and 10.0 mg/kg of PPLⅥ, respectively. PPLⅥ treatment increased the expression of cleaved Caspase3, Caspase9 and Bax and decreased the expression of Bcl-2 in colonic epithelial cells.
    CONCLUSIONS:
    PPLⅥ can inhibit DMH/DSS-induced colon tumor formation in ICR mice partly through inducing apoptosis of abnormal colonic epithelial cells via the intrinsic pathway of apoptosis.
    Polyphyllin VI Description
    Source: The rhizomes of Paris yunnanensis Franch.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3533 mL 6.7667 mL 13.5334 mL 27.0669 mL 33.8336 mL
    5 mM 0.2707 mL 1.3533 mL 2.7067 mL 5.4134 mL 6.7667 mL
    10 mM 0.1353 mL 0.6767 mL 1.3533 mL 2.7067 mL 3.3834 mL
    50 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.5413 mL 0.6767 mL
    100 mM 0.0135 mL 0.0677 mL 0.1353 mL 0.2707 mL 0.3383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Biomed Chromatogr. 2013 Mar;27(3):343-8.
    Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS.[Pubmed: 22903625]
    For the first time, a rapid and specific LC-MS-MS method has been developed for the analysis of polyphyllin I, polyphyllin II, Polyphyllin VI and Polyphyllin VII in beagle dog plasma.
    METHODS AND RESULTS:
    The method was applied to study the pharmacokinetics of Rhizoma Paridis extracts containing polyphyllin I, polyphyllin II, Polyphyllin VI and Polyphyllin VII. The analysis was carried out on an Agilent Zorbax XDB-C(18) reversed-phase column (100 × 2.1 mm, 1.8 μm) by isocratic elution with acetonitrile and water (50:50, v/v). The flow rate was 0.25 mL/min. All analytes including internal standards were monitored by selected reaction monitoring with an electrospray ionization source. Linear responses were obtained for polyphyllin I, polyphyllin II, Polyphyllin VI and Polyphyllin VII ranging from 10 to 5000 ng/mL. The intra-and inter-day precisions (RSDs) were less than 6.66 and 9.15%. The extraction recovery ranged from 95.53 to 104.21% with RSD less than 8.69%. Stability studies showed that polyphyllin I, polyphyllin II, Polyphyllin VI and Polyphyllin VII were stable in preparation and analytical process.
    CONCLUSIONS:
    The validated method was successfully used to determine the concentration-time profiles of polyphyllin I, polyphyllin II, Polyphyllin VI and Polyphyllin VII.