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    Rhaponticin 2''-O-gallate
    Rhaponticin 2''-O-gallate
    Information
    CAS No. 94356-24-8 Price $288 / 5mg
    Catalog No.CFN91100Purity>=98%
    Molecular Weight572.51Type of CompoundPhenols
    FormulaC28H28O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Rhaponticin 2''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
    Targets: NO
    In vitro:
    Bioorg Med Chem Lett. 2000 Feb 21;10(4):323-7.
    Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.[Pubmed: 10714491 ]

    METHODS AND RESULTS:
    Two new anthraquinone glucosides [chrysophanol 8-O-beta-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-beta-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-beta-D-glucopyranoside), and two stilbene glucoside gallates (Rhaponticin 2''-O-gallate, Rhaponticin 6''-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
    CONCLUSIONS:
    The oxygen functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the alpha,beta-double bond did not affect the activity. Furthermore, the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction.
    Rhaponticin 2''-O-gallate Description
    Source: The roots of Rumex obtusifolius L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7467 mL 8.7335 mL 17.4669 mL 34.9339 mL 43.6674 mL
    5 mM 0.3493 mL 1.7467 mL 3.4934 mL 6.9868 mL 8.7335 mL
    10 mM 0.1747 mL 0.8733 mL 1.7467 mL 3.4934 mL 4.3667 mL
    50 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.6987 mL 0.8733 mL
    100 mM 0.0175 mL 0.0873 mL 0.1747 mL 0.3493 mL 0.4367 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.