|Description:||1. Salvianolic acid C has antioxidant effect .|
2. Salvianolic acid C exhibits potent XOD inhibitory activity with an IC(50) of 9.07 μM.
3. Salvianolic acid C enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects.
|Targets:||Immunology & Inflammation related|
|Source:||The root of Salvia miltiorrhiza Bge.|
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.0307 mL||10.1535 mL||20.307 mL||40.6141 mL||50.7676 mL|
|5 mM||0.4061 mL||2.0307 mL||4.0614 mL||8.1228 mL||10.1535 mL|
|10 mM||0.2031 mL||1.0154 mL||2.0307 mL||4.0614 mL||5.0768 mL|
|50 mM||0.0406 mL||0.2031 mL||0.4061 mL||0.8123 mL||1.0154 mL|
|100 mM||0.0203 mL||0.1015 mL||0.2031 mL||0.4061 mL||0.5077 mL|
Phytomedicine. 2015 Apr 15;22(4):444-51.
|In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.[Pubmed: 25925966]|
|Salvianolic acid C (Ki = 8.6 μM) was proved to be a moderate noncompetitive sEH inhibitor. In consistent with the inhibition results of the pure compounds, the 75% ethanol extract of Danshen (EE, IC50 = 86.5 μg/ml) which contained more tanshinone IIA and cryptotanshinone exhibited more potent inhibition on sEH than the water extract (WE, IC50 > 200 μg/ml) or 1 M NaHCO3 (BE, IC50 > 200 μg/ml) extract. CONCLUSION: These data indicated that using the ethanol fraction of Danshen and increasing the amounts of tanshinone IIA, cryptotanshinone and Salvianolic acid C, especially the contents of tanshinone IIA in Danshen extract or preparations to enhance the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects, and that herbal medicines could be an untapped reservoir for sEH-inhibition agents and developing sEH inhibitors from the cardiovascular protective and anti-inflammatory herbs is a promising approach.|