ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $329.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J. of Med. Plant Research.2013, 90-151New Zealand J. Forestry Sci.2014, 44:17Pharmacogn Mag.2015, 11:S585-91Tumour Biol.2015, 36(12):9385-93Molecules.2016, 21(6)Phytochem Anal.2016, 27(5):296-303J Exp Bot.2016, 67(12):3777-88RSC Advances2017, 86
Nutrients.2018, 10(12)Neuropharmacology.2018, 131:68-82International Food Research Journ...2018...Korean Journal of Medicinal Crop ...2018...Phytother Res.2018, 32(12):2551-2559Biol Pharm Bull.2018, 41(11):1685-1693Journal of Life Science2018, 917-922Nutrients.2019, 11(11):E2694
Drug Invention Today...2019...Plant Physiol Biochem.2019, 144:355-364Int J Mol Sci.2019, 21(1):E265J Ethnopharmacol.2019, 241:112025Oncol Rep.2019, 41(4):2453-2463J Agric Food Chem....2019...United States Patent Application...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Uniwersytet Jagielloński w Kra... (Poland)University of Wuerzburg (Germany)Lodz University of Technology (Poland)Universidade da Beira Interior (Germany)
Almansora University (Egypt)Universidade Federal de Pernamb... (Brazil)University of Padjajaran (Indonesia)University of Cincinnati (USA)
Chiang Mai University (Thailand)Monash University Malaysia (Malaysia)Universitas Airlangga (Indonesia)
Related Screening Libraries
|| The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.|
Salvianolic acid F Description
||The roots of Salvia miltiorrhiza Bge.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Eur. J. Org. Chem., 2016, 36:5941–9. |
|Divergent Synthesis of Styryl–Cinnamate Hybrid Analogues Inspired by the Natural Product Salvianolic Acid F as a Premise To Investigate Their Anticancer Activity and Its Metabolomic Profiling[Reference: WebLink]|
|The natural product Salvianolic acid F- inspired protecting-group-free synthesis of hydroxylated styryl-cinnamate hybrids (C6-C2-C6-C3 unit) has been achieved by step-economical route via sequential double C-C bond formation in one pot.
METHODS AND RESULTS:
The present method involves multiple reactions (Perkin-condensation/ decarboxylation-Heck cross-coupling reactions) using simple precursors (i.e. hydroxylated benzaldehyde, arylacetic acid and acrylic acid derivatives) in one pot which yields desired unnatural small hybrid molecules (1-12) in varying yields of 35-65%with E-selectivity under microwave irradiation whereas the reported conventional route for synthesis of Salvianolic acid F itself requires six steps with an overall yield of 10.0% besides tedious separation of E/Z isomers that arise from Wittig reaction.Apart from an economical synthesis and products diversity, we herein report the potential of some hybrid molecules (3,8,10 and 11), with the catecholic core, to selectively inhibit glioma cells. The intrinsic mode of action (MOA) for our lead molecule involving caspase 6 and quinonemethide pathway is also reported based on 1HNMR-guided metabolomic profiling.
We emphatically demonstrate the role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.