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    Natural Products
    Serrin A
    Information
    CAS No. 845959-98-0 Price
    Catalog No.CFN96677Purity>=98%
    Molecular Weight390.47Type of CompoundDiterpenoids
    FormulaC22H30O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Package
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    Related Libraries
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  • Biological Activity
    Description: Serrin A shows weak to moderate cytotoxic activities (IC50<10 uM) against two human cancer cell lines.
    In vitro:
    Phytochemistry. 2016 Feb;122:119-125.
    ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities.[Pubmed: 26671519 ]
    Investigation of the hydrophobic extract of Rabdosia serra (Lamiaceae) led to the isolation of seven ent-6,7-secokaurane diterpenoids rabdosins E-K, along with twelve known ent-kaurane diterpenoids.
    METHODS AND RESULTS:
    Their structures were established by extensive spectroscopic analysis. The absolute configurations of rabdosins E, F, H and I were determined by single-crystal X-ray diffraction, with rabdosin E having a 3,20-epoxy group. These diterpenoids could be divided into two types according to their skeletons: rabdosins E-J are ent-6,20-epoxy-6,7-secokaur-1,7-olides, and rabdosin K is an ent-6,7-secokaur-7,20-olide.
    CONCLUSIONS:
    Cytotoxicity evaluation showed that serrin B, Serrin A, isodocarpin and lushanrubescensin J exhibited weak to moderate cytotoxic activities (IC50<10μM) against two human cancer cell lines.
    Serrin A Description
    Source: The herbs of Rabdosia serra.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.561 mL 12.8051 mL 25.6102 mL 51.2203 mL 64.0254 mL
    5 mM 0.5122 mL 2.561 mL 5.122 mL 10.2441 mL 12.8051 mL
    10 mM 0.2561 mL 1.2805 mL 2.561 mL 5.122 mL 6.4025 mL
    50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.0244 mL 1.2805 mL
    100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.5122 mL 0.6403 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.