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    Strychnistenolide
    Information
    CAS No. 332372-09-5 Price
    Catalog No.CFN91933Purity>=98%
    Molecular Weight262.30Type of CompoundSesquiterpenoids
    FormulaC15H18O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Description: Reference standards.
    In vitro:
    J Nat Prod. 2009 Aug;72(8):1497-501.
    Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, Strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neolinderalactone, and linderalactone. The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.
    CONCLUSIONS:
    Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.
    Strychnistenolide Description
    Source: The roots of Lindera aggregata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8124 mL 19.0621 mL 38.1243 mL 76.2486 mL 95.3107 mL
    5 mM 0.7625 mL 3.8124 mL 7.6249 mL 15.2497 mL 19.0621 mL
    10 mM 0.3812 mL 1.9062 mL 3.8124 mL 7.6249 mL 9.5311 mL
    50 mM 0.0762 mL 0.3812 mL 0.7625 mL 1.525 mL 1.9062 mL
    100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.7625 mL 0.9531 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2001 Mar;64(3):286-8.
    New eudesmane sesquiterpenes from the root of Lindera strychnifolia.[Pubmed: 11277740]

    METHODS AND RESULTS:
    Strychnistenolide (1) and its acetate 2 were isolated from the root of Lindera strychnifolia, along with a novel rearranged type of secoeudesmane, strychnilactone (3). Their structures were elucidated by extensive analysis of their NMR spectra, including 2D NMR techniques, together with an X-ray analysis for 3.
    CONCLUSIONS:
    Strychnistenolide exists as a single stereoisomer in CHCl(3), but in pyridine is epimerized.