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    Swertianolin
    Information
    CAS No. 23445-00-3 Price $326 / 10mg
    Catalog No.CFN90618Purity>=98%
    Molecular Weight436.37Type of CompoundXanthones
    FormulaC20H20O11Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Swertianolin shows anti-acetylcholinesterase activity effects, it shows significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Swertianolin can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
    Targets: AChE
    In vitro:
    Planta Med. 2004 Oct;70(10):1011-4.
    Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.[Pubmed: 15490334 ]
    In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity.
    METHODS AND RESULTS:
    A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norSwertianolin), and bellidifolin 8-O-beta-glucopyranoside (Swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.
    Journal of Liaoning Normal University, 2003 , 26 (2) :171-173.
    Voltammetric Behavior of Swertianolin and Its Scavenging to Free Radicals[Reference: WebLink]
    The electrochemical behavior of Swertianolin and its scavenging to free radicals have been studied.
    METHODS AND RESULTS:
    A irreversible adsorpted reduction peak involving two electrons and two protons has been obtained in the medium of phosphate buffer(pH 8.2). The peak potential was at -1.61V(vs.SCE).
    CONCLUSIONS:
    Swertianolin showed that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.