Science | Nature | Cell | View More
Natural Products
Swertianolin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Swertianolin
Price: $268 / 10mg
CAS No.: 23445-00-3
Catalog No.: CFN90618
Molecular Formula: C20H20O11
Molecular Weight: 436.37 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Powder
Source: The herbs of Swertia bimaculata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $76.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Instituto Politécnico de Bragan?a (Portugal)
  • Medical University of South Car... (USA)
  • VIB Department of Plant Systems... (Belgium)
  • Research Unit Molecular Epigene... (Germany)
  • University of Mysore (India)
  • National Cancer Institute (USA)
  • Osmania University (India)
  • Martin Luther University of Hal... (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Chinese University of Hong Kong (China)
  • University of Vigo (Spain)
  • More...
Package
Featured Products
1,2,3,4,6-O-Pentagalloylglucose

Catalog No: CFN90192
CAS No: 14937-32-7
Price: $80/20mg
Myricitrin

Catalog No: CFN99840
CAS No: 17912-87-7
Price: $40/20mg
Asiaticoside

Catalog No: CFN99912
CAS No: 16830-15-2
Price: $40/20mg
Licochalcone A

Catalog No: CFN99575
CAS No: 58749-22-7
Price: $88/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Vitexin 2''-glucoside

Catalog No: CFN70421
CAS No: 61360-94-9
Price: $ / mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Loganin

Catalog No: CFN99858
CAS No: 18524-94-2
Price: $30/20mg
Gambogic acid

Catalog No: CFN90172
CAS No: 2752-65-0
Price: $30/20mg
(+)-Taxifolin

Catalog No: CFN99183
CAS No: 17654-26-1
Price: $70/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Swertianolin shows anti-acetylcholinesterase activity effects, it shows significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Swertianolin can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
Targets: AChR
In vitro:
Planta Med. 2004 Oct;70(10):1011-4.
Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.[Pubmed: 15490334 ]
In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity.
METHODS AND RESULTS:
A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norSwertianolin), and bellidifolin 8-O-beta-glucopyranoside (Swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.
Journal of Liaoning Normal University, 2003 , 26 (2) :171-173.
Voltammetric Behavior of Swertianolin and Its Scavenging to Free Radicals[Reference: WebLink]
The electrochemical behavior of Swertianolin and its scavenging to free radicals have been studied.
METHODS AND RESULTS:
A irreversible adsorpted reduction peak involving two electrons and two protons has been obtained in the medium of phosphate buffer(pH 8.2). The peak potential was at -1.61V(vs.SCE).
CONCLUSIONS:
Swertianolin showed that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
In vivo:
J Ethnopharmacol. 2014 May 28;154(1):259-66.
The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch.[Pubmed: 24746481 ]
Total iridoids and xanthones (TIXS) were extracted from Swertia mussotii Franch, one of the most important eight Tibetan medicines in China, which was recorded in the book of Jingzhu Bencao and used for clinical treatment of cholestatic hepatitis for many years. Our aim was to study the hepatoprotective effect and chemical constituents of the TIXS.
METHODS AND RESULTS:
Crude extracts were prepared using 90% ethanol, and individual fractions were collected following HPD-300 macroporous resin column chromatography. HPLC/MS was applied to qualitatively and quantitatively analyze the TIXS. Then, the alpha-naphthylisot hiocyanate-induced liver damage model was used to assess the hepatoprotective effect of the TIXS. A total of 12 compounds were identified by the fingerprint chromatography of the TIXS, and swertiamarin and Swertianolin were shown to be its two main components. Oral administration of the TIXS at a dose of 35, 70 or 140 mg kg(-1), swertiamarin at a dose of 20 mg kg(-1) or Swertianolin at a dose of 20 mg kg(-1), for 7 days in mice significantly reduced the alpha-naphthylisot hiocyanate-induced levels of alanine aminotransferase, aspartate aminotransferase and the total and direct bilirubins, and increased the bile flow (P<0.01).
CONCLUSIONS:
These findings suggest that the TIXS exhibits significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Its active constituents include swertiamarin and Swertianolin.
Swertianolin Description
Source: The herbs of Swertia bimaculata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Annphenone

Catalog No: CFN95426
CAS No: 61775-18-6
Price: $318/10mg
Ganolucidic acid B

Catalog No: CFN95513
CAS No: 98683-75-1
Price: $413/5mg
cis-Aegineoside

Catalog No: CFN95295
CAS No: N/A
Price: $413/5mg
Licoricesaponin H2

Catalog No: CFN95173
CAS No: 118441-85-3
Price: $218/10mg
Apigenin 7-[rhamnosyl-(1->2)-galac...

Catalog No: CFN95352
CAS No: 124167-97-1
Price: $318/10mg
Magnaldehyde B

Catalog No: CFN95075
CAS No: 92829-72-6
Price: $318/5mg
Bocconoline

Catalog No: CFN95373
CAS No: 32906-88-0
Price: $413/5mg
Odontoside

Catalog No: CFN95530
CAS No: 20300-50-9
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2916 mL 11.4582 mL 22.9163 mL 45.8327 mL 57.2908 mL
5 mM 0.4583 mL 2.2916 mL 4.5833 mL 9.1665 mL 11.4582 mL
10 mM 0.2292 mL 1.1458 mL 2.2916 mL 4.5833 mL 5.7291 mL
50 mM 0.0458 mL 0.2292 mL 0.4583 mL 0.9167 mL 1.1458 mL
100 mM 0.0229 mL 0.1146 mL 0.2292 mL 0.4583 mL 0.5729 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
《Journal of Qinghai Nationalities University(Education Science Edition)》 2011-05
Determination of Swertianolin in Gentianopsis Paludosa(Munro) Ma by RP-HPLC[Reference: WebLink]

METHODS AND RESULTS:
To establish a quantitative method determination of Swertianolin in Gentianopsis paludosa(Munro) Ma by RP-HPLC.The sample were separated on the column of Kromasil-C18(4.6mm×250mm,5μm) which eluted with 55% methanol and water(containing 0.04% phosphoric acid) with detected wavelength at 254 nm.The flow rate was 0.8 mL·min-1,and the column temperature was 30 ℃.The components were base-isolated.
CONCLUSIONS:
The linear ranges of Swertianolin was 0.275-1.65μg(r=0.9997).The average recovery rate was 99.6%(RSD=2.7%).The method is rapid and precise.
Phytochem Anal. 2016 May;27(3-4):158-67.
Chemotaxonomic Studies of Nine Gentianaceae Species from Western China Based on Liquid Chromatography Tandem Mass Spectrometry and Fourier Transform Infrared Spectroscopy.[Pubmed: 26919544]
Gentianaceae species which widely occur all over the world are used as folk medicine and raw food material with bitter properties. Although comparative analysis on metabolites in several Gentianaceae species has been reported, metabolic similarities used for chemotaxonomic studies are not yet clear. To systematically characterise the variations of holistic metabolome and characteristic metabolites (iridoid glycosides and phenols) in nine Gentianaceae species from western China.
METHODS AND RESULTS:
Fourier transform infrared (FT-IR) spectroscopy was applied to determine the variations of holistic metabolome. A targeted metabolic profiling using liquid chromatography with tandem mass spectrometry (LC-MS/MS) was established for determination of seven characteristic metabolites and identification of their derivatives. Both FT-IR and LC-MS/MS data were subjected to chemometrics analysis for exploring variations in iridoid glycosides and phenols within these species. Holistic metabolome in genera Gentiana and Swertia was largely different. Diversity of the biosynthetic pathway of iridoid glycosides was also observed in these species. Principal component analysis (PCA) showed a clear separation according to infrageneric classifications of genus Gentiana. Some secondary metabolites, such as mangiferin, rhodenthoside A-C, isoorientin, isovitexin, amarogentin, and Swertianolin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. Furthermore, the accumulation of the six major metabolites seems to depend on geographical regions in Sect. Monopodiae and Sect. Cruciata.
CONCLUSIONS:
The combination of LC-MS/MS and FT-IR would provide some potential evidence on chemotaxonomic studies of Gentianaceae.
1,2,3,4,6-O-Pentagalloylglucose

Catalog No: CFN90192
CAS No: 14937-32-7
Price: $80/20mg
Myricitrin

Catalog No: CFN99840
CAS No: 17912-87-7
Price: $40/20mg
Asiaticoside

Catalog No: CFN99912
CAS No: 16830-15-2
Price: $40/20mg
Licochalcone A

Catalog No: CFN99575
CAS No: 58749-22-7
Price: $88/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Vitexin 2''-glucoside

Catalog No: CFN70421
CAS No: 61360-94-9
Price: $ / mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Loganin

Catalog No: CFN99858
CAS No: 18524-94-2
Price: $30/20mg
Gambogic acid

Catalog No: CFN90172
CAS No: 2752-65-0
Price: $30/20mg
(+)-Taxifolin

Catalog No: CFN99183
CAS No: 17654-26-1
Price: $70/20mg
Tags: buy Swertianolin | Swertianolin supplier | purchase Swertianolin | Swertianolin cost | Swertianolin manufacturer | order Swertianolin | Swertianolin distributor