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    Swertianolin
    Swertianolin
    Information
    CAS No. 23445-00-3 Price $326 / 10mg
    Catalog No.CFN90618Purity>=98%
    Molecular Weight436.37Type of CompoundXanthones
    FormulaC20H20O11Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Swertianolin Description
    Source: The herbs of Swertia bimaculata
    Biological Activity or Inhibitors: 1. Swertianolin, mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species.
    2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate.
    3. Swertianolin shows anti-acetylcholinesterase activity effects.
    4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2916 mL 11.4582 mL 22.9163 mL 45.8327 mL 57.2908 mL
    5 mM 0.4583 mL 2.2916 mL 4.5833 mL 9.1665 mL 11.4582 mL
    10 mM 0.2292 mL 1.1458 mL 2.2916 mL 4.5833 mL 5.7291 mL
    50 mM 0.0458 mL 0.2292 mL 0.4583 mL 0.9167 mL 1.1458 mL
    100 mM 0.0229 mL 0.1146 mL 0.2292 mL 0.4583 mL 0.5729 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Swertianolin References Information
    Citation [1]

    《Journal of Qinghai Nationalities University(Education Science Edition)》 2011-05

    Determination of Swertianolin in Gentianopsis Paludosa(Munro) Ma by RP-HPLC[Reference: WebLink]
    To establish a quantitative method determination of Swertianolin in Gentianopsis paludosa(Munro) Ma by RP-HPLC.The sample were separated on the column of Kromasil-C18(4.6mm×250mm,5μm) which eluted with 55% methanol and water(containing 0.04% phosphoric acid) with detected wavelength at 254 nm.The flow rate was 0.8 mL·min-1,and the column temperature was 30 ℃.The components were base-isolated.The linear ranges of Swertianolin was 0.275-1.65μg(r=0.9997).The average recovery rate was 99.6%(RSD=2.7%).The method is rapid and precise.
    Citation [2]

    Phytochem Anal. 2016 May;27(3-4):158-67.

    Chemotaxonomic Studies of Nine Gentianaceae Species from Western China Based on Liquid Chromatography Tandem Mass Spectrometry and Fourier Transform Infrared Spectroscopy.[Pubmed: 26919544]
    Holistic metabolome in genera Gentiana and Swertia was largely different. Diversity of the biosynthetic pathway of iridoid glycosides was also observed in these species. Principal component analysis (PCA) showed a clear separation according to infrageneric classifications of genus Gentiana. Some secondary metabolites, such as mangiferin, rhodenthoside A-C, isoorientin, isovitexin, amarogentin, and Swertianolin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. Furthermore, the accumulation of the six major metabolites seems to depend on geographical regions in Sect. Monopodiae and Sect. Cruciata.
    Citation [3]

    J Ethnopharmacol. 2014 May 28;154(1):259-66.

    The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch.[Pubmed: 24746481 ]
    A total of 12 compounds were identified by the fingerprint chromatography of the TIXS, and swertiamarin and Swertianolin were shown to be its two main components. Oral administration of the TIXS at a dose of 35, 70 or 140 mg kg(-1), swertiamarin at a dose of 20 mg kg(-1) or Swertianolin at a dose of 20 mg kg(-1), for 7 days in mice significantly reduced the alpha-naphthylisot hiocyanate-induced levels of alanine aminotransferase, aspartate aminotransferase and the total and direct bilirubins, and increased the bile flow (P<0.01). CONCLUSION: These findings suggest that the TIXS exhibits significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Its active constituents include swertiamarin and Swertianolin.
    Citation [4]

    Planta Med. 2004 Oct;70(10):1011-4.

    Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.[Pubmed: 15490334 ]
    In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norSwertianolin), and bellidifolin 8-O-beta-glucopyranoside (Swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.
    Citation [5]

    Journal of Liaoning Normal University, 2003 , 26 (2) :171-173.

    Voltammetric Behavior of Swertianolin and Its Scavenging to Free Radicals[Reference: WebLink]
    The electrochemical behavior of Swertianolin and its scavenging to free radicals have been studied. A irreversible adsorpted reduction peak involving two electrons and two protons has been obtained in the medium of phosphate buffer(pH 8.2). The peak potential was at -1.61V(vs.SCE). Swertianolin showed that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.