Science | Nature | Cell | View More
Natural Products
Tirotundin
Tirotundin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tirotundin
Price:
CAS No.: 56377-67-4
Catalog No.: CFN98943
Molecular Formula: C19H28O6
Molecular Weight: 352.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The leave of Tithonia diversifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Illinois at Chicago (USA)
  • Institute of Chinese Materia Me... (China)
  • National Research Council of Ca... (Canada)
  • Tokyo Woman's Christian University (Japan)
  • Martin Luther University of Hal... (Germany)
  • Shanghai Institute of Biochemis... (China)
  • Universidad de Buenos Aires (Argentina)
  • University of East Anglia (United Kingdom)
  • University of South Australia (Australia)
  • Donald Danforth Plant Science C... (USA)
  • Charles University in Prague (Czech Republic)
  • More...
Package
Featured Products
Cyanidin Chloride

Catalog No: CFN99741
CAS No: 528-58-5
Price: $198/20mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
20(R)-Ginsenoside Rh2

Catalog No: CFN90340
CAS No: 112246-15-8
Price: $70/20mg
Bergenin

Catalog No: CFN98724
CAS No: 477-90-7
Price: $30/20mg
Malvidin-3-O-glucoside chloride

Catalog No: CFN92049
CAS No: 7228-78-6
Price: $238/10mg
Jervine

Catalog No: CFN90955
CAS No: 469-59-0
Price: $40/20mg
Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Lycorine

Catalog No: CFN90263
CAS No: 476-28-8
Price: $30/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.
Targets: PPAR | NF-kB | COX
In vitro:
Planta Med. 1998 Oct;64(7):588-93.
Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets.[Pubmed: 9810261]
In Central America leaf extracts from the Asteraceae Tithonia diversifolia are used externally for the treatment of haematomas and wounds. Therefore, the main sesquiterpene lactones (Sls) of this species growing in Costa Rica, diversifolin (1), diversifolin methyl ether (2), and Tirotundin (3), were studied for their anti-inflammatory activity.
METHODS AND RESULTS:
We determined whether these compounds inhibit cyclooxygenase-I, phospholipase A2, or the transcription factor NF-kappa B. Here we show that these Sls do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B. Thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.
CONCLUSIONS:
Our results indicate that the inhibitory activity of compounds 1-3 is due to alkylation of cysteine residues, which are probably located in the DNA binding domain of NF-kappa B. The Sls were also studied for their antibacterial activity, but only Sl 1 was moderately active against Bacillus subtilis in the agar plate diffusion test.
Tirotundin Description
Source: The leave of Tithonia diversifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isololiolide

Catalog No: CFN95106
CAS No: 38274-00-9
Price: $318/5mg
Ginsenoside Rd2 (Quinquenoside L10...

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Peucenidin

Catalog No: CFN95272
CAS No: 33044-93-8
Price: $318/5mg
Methyl caffeate acid

Catalog No: CFN95561
CAS No: 3843-74-1
Price: $ / mg
N-trans-caffeoyloctopamine

Catalog No: CFN95264
CAS No: 1378868-10-0
Price: $413/5mg
7-O-(4-beta-D-glucopyranosyloxy-3-...

Catalog No: CFN95365
CAS No: 469899-55-6
Price: $368/5mg
Lappaol A

Catalog No: CFN95067
CAS No: 62333-08-8
Price: $333/10mg
ZP-amide C

Catalog No: CFN95362
CAS No: 412316-38-2
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8377 mL 14.1884 mL 28.3768 mL 56.7537 mL 70.9421 mL
5 mM 0.5675 mL 2.8377 mL 5.6754 mL 11.3507 mL 14.1884 mL
10 mM 0.2838 mL 1.4188 mL 2.8377 mL 5.6754 mL 7.0942 mL
50 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.1351 mL 1.4188 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5675 mL 0.7094 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2954-8.
Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.[Pubmed: 22424975]
Sesquiterpene lactones, Tirotundin and tagitinin A, were isolated from T. diversifolia and evaluated for their activity against PPARs by the transient transfection reporter assay.
METHODS AND RESULTS:
Tirotundin and tagitinin A transactivated PPARγ dependent promoters including PPRE (PPARγ response element), SHP, and ABCA1 gene promoters in dose-dependent manner. Furthermore, the fluorescence polarization competitive binding assay showed that Tirotundin (IC(50)=27 μM) and tagitinin A (IC(50)=55 μM) enhanced PPARγ transactivation activity by directly binding to PPARγ ligand binding domain. Additionally, they stimulated the transactivation of PPARα dependent SULT2A1 gene promoter by 2.3-fold of vehicle effect at 10 μM.
CONCLUSIONS:
These results highly indicated that Tirotundin and tagitinin A are the active components of T. diversifolia to exert anti-diabetic effect through PPARγ pathway. Moreover, these sesquiterpene lactones behaved as PPARα/γ dual agonists so they might be useful as the potential herbal treatment for diabetes.
Cyanidin Chloride

Catalog No: CFN99741
CAS No: 528-58-5
Price: $198/20mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
20(R)-Ginsenoside Rh2

Catalog No: CFN90340
CAS No: 112246-15-8
Price: $70/20mg
Bergenin

Catalog No: CFN98724
CAS No: 477-90-7
Price: $30/20mg
Malvidin-3-O-glucoside chloride

Catalog No: CFN92049
CAS No: 7228-78-6
Price: $238/10mg
Jervine

Catalog No: CFN90955
CAS No: 469-59-0
Price: $40/20mg
Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Lycorine

Catalog No: CFN90263
CAS No: 476-28-8
Price: $30/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Tags: buy Tirotundin | Tirotundin supplier | purchase Tirotundin | Tirotundin cost | Tirotundin manufacturer | order Tirotundin | Tirotundin distributor