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    dl-Aloesol
    dl-Aloesol
    Information
    CAS No. 104871-04-7 Price
    Catalog No.CFN96962Purity>=98%
    Molecular Weight234.25Type of CompoundPhenols
    FormulaC13H14O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Description: dl-Aloesol is a natural product from the secondary metabolites of endophytic fungus HCCB06030.
    dl-Aloesol Description
    Source: The secondary metabolites of endophytic fungus HCCB06030.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

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    IF=22.415(2019)

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    IF=14.548(2019)

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    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2689 mL 21.3447 mL 42.6894 mL 85.3789 mL 106.7236 mL
    5 mM 0.8538 mL 4.2689 mL 8.5379 mL 17.0758 mL 21.3447 mL
    10 mM 0.4269 mL 2.1345 mL 4.2689 mL 8.5379 mL 10.6724 mL
    50 mM 0.0854 mL 0.4269 mL 0.8538 mL 1.7076 mL 2.1345 mL
    100 mM 0.0427 mL 0.2134 mL 0.4269 mL 0.8538 mL 1.0672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chem Pharm Bull (Tokyo). 1991 Mar;39(3):704-8.
    Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain.[Pubmed: 2070451]

    METHODS AND RESULTS:
    By anaerobic incubation with a bacterial mixture from human feces, aloesin (aloeresin B; 1) was converted to 2-acetonyl-7-hydroxy-5-methylchromone (aloesone; 3) and dl-7-hydroxy-2-(2'-hydroxypropyl)-5-methylchromone (aloesol; 4a + 4b) through a cleavage of the C-glucosyl bond, followed by reduction of the acetonyl side chain. An analogous compound, aloeresin A (2), was converted to p-coumaric acid and aloesin (1), the latter being subsequently transformed to aloesone (3) and dl-Aloesol (4a + 4b). On the other hand, 7-O-methylated derivatives (7, 5a and 5b) of aloesin and of 8-C-glucosylaloesol were not cleaved to the corresponding aglycones, suggesting the importance of a free hydroxy group adjacent to the C-glucosyl group in the molecule for the bacterial cleavage of aloesin derivatives.
    CONCLUSIONS:
    This is the first report on the cleavage of the C-glycosyl bond of chromone C-glucosides by intestinal bacteria.