- ChemFaces is a professional high-purity natural products manufacturer.
- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
ChemFaces products have been cited in many studies from excellent and top scientific journals
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Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
- Pak J Pharm Sci.2019, 32(6)
- ACS Omega.2023, 9(1):1278-1286.
- University of Stuttgart2021, 11682.
- Korean Journal of Pharmacognosy...2018...
- Tissue Cell.2022, 78:101901.
- Molecules. 2013, 18(11):14105-21
- Agriculture2022, 12(12), 2173.
- Int J Mol Sci.2017, 18(5)
- BMC Complement Altern Med.2014, 14:352
- Sci Rep.2018, 8(1)
- Institute of Food Science & Techn...2021...
- Pharmaceuticals (Basel)....2024...
- Food Res Int.2021, 148:110607.
- Antiviral Res.2013, 98(3):386-93
- Metabolites.2023, 13(5):625.
- Indian J Pharm Sci.2022, 84(3):144-151
- Int J Mol Sci.2019, 20(11):E2734
- Mutlu Yanic S, Ates EG. JOTCSA....2023...
- Front Pharmacol.2017, 8:673
- Curr Issues Mol Biol....2022...
- Pharmaceuticals (Basel)....2024...
- RSC Advances2017, 86
- Front Pharmacol.2016, 7:460
- More...
Our products had been exported to the following research institutions and universities, And still growing.
- Weizmann Institute of Science (Israel)
- University of Wollongong (Australia)
- Aveiro University (Portugal)
- Uniwersytet Gdański (Poland)
- Universidade da Beira Interior (Germany)
- Georgia Institute of Technology (USA)
- Macau University of Science and... (China)
- Srinakharinwirot University (Thailand)
- National Cancer Center Research... (Japan)
- Universit?t Basel (Switzerland)
- Siksha O Anusandhan University (India)
- More...
- Nat Commun.2019, 10(1):5169
- Molecules.2022, 27(5):1675
- Pharmaceutics.2022, 14(3):564.
- Front Immunol.2020, 11:598556.
- Molecules.2019, 24(9):E1719
- PLoS One.2018, 13(11):e0208055
- J Drug Target.2016, 24:1-28
- Applied Biological Chemistry2023, 66:8
- Pharmaceuticals (Basel). 2021, 14(10):986.
- Exp Biol Med (Maywood).2019, 244(16):1463-1474
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities, it also has hypoglycemic activity. |
| Targets: |
PARP |
| In vitro: |
| J. Enzym. Inhib. Med.Chem., 2015(3):1-6. | | Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed: 25068729 ] | Aminomethyl derivatives of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities.
METHODS AND RESULTS:
The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases.
CONCLUSIONS:
Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities. |
|
1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene Description
| Source: |
The rhizomes of Curcuma longa L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.201 mL |
16.0051 mL |
32.0102 mL |
64.0205 mL |
80.0256 mL |
| 5 mM |
0.6402 mL |
3.201 mL |
6.402 mL |
12.8041 mL |
16.0051 mL |
| 10 mM |
0.3201 mL |
1.6005 mL |
3.201 mL |
6.402 mL |
8.0026 mL |
| 50 mM |
0.064 mL |
0.3201 mL |
0.6402 mL |
1.2804 mL |
1.6005 mL |
| 100 mM |
0.032 mL |
0.1601 mL |
0.3201 mL |
0.6402 mL |
0.8003 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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