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    Natural Products
    2,3',4,6-Tetrahydroxybenzophenone
    Information
    CAS No. 26271-33-0 Price
    Catalog No.CFN98302Purity>=98%
    Molecular Weight246.2 Type of CompoundXanthones
    FormulaC13H10O5Physical DescriptionYellow powder
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    2,3',4,6-Tetrahydroxybenzophenone

    2,3',4,6-Tetrahydroxybenzophenone
    Product Name 2,3',4,6-Tetrahydroxybenzophenone
    CAS No.: 26271-33-0
    Catalog No.: CFN98302
    Molecular Formula: C13H10O5
    Molecular Weight: 246.2 g/mol
    Purity: >=98%
    Type of Compound: Xanthones
    Physical Desc.: Yellow powder
    Targets: P450 (e.g. CYP17)
    Source: The herbs of Garcinia cowa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Sci Rep.2017, 7:467-479
  • J Agric Food Chem.2016, 64(35):6783-90
  • American Association for Anatomy2020, doi: 10.1002.
  • Eur J Pharmacol.2020, 889:173589.
  • Plant Cell Tiss Org2020, 1-16
  • BMC Complement Altern Med.2014, 14:242
  • Biochemical Systematics and Ecology2018, 81
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Universidade Estadual Paulista2017, 11449
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Xanthones Compound Library
  • P450 (e.g. CYP17) Inhibitor Library
  • Biological Activity
    Description: 2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Bioorg Chem. 2014 Jun;54:60-7.
    Cytotoxic benzophenone and triterpene from Garcinia hombroniana.[Pubmed: 24813683]

    METHODS AND RESULTS:
    2,3',4,5'-tetrahydroxy-6-methoxybenzophenone(1), 2,3',4,4'-tetrahydroxy-6-methoxybenzophenone (2), 2,3',4,6-Tetrahydroxybenzophenone (3), 1,3,6,7-tetrahydroxyxanthone (4), 3,3',4',5,7-pentahydroxyflavone (5),3,3',5,5',7-pentahydroxyflavanone (6), 3,3',4',5,5',7-hexahydroxyflavone (7), 4',5,7-trihydroxyflavanone-7-rutinoside (8), 18(13→17)-abeo-3β-acetoxy-9α,13β-lanost-24E-en-26-oic acid (9), garcihombronane B (10), garcihombronane D (11), friedelan-3-one (12), lupeol (13), stigmasterol (14) and stigmasterol glucoside (15).
    CONCLUSIONS:
    In the in vitro cytotoxicity against MCF-7, DBTRG, U2OS and PC-3 cell lines, compounds 1 and 9 displayed good cytotoxic effects against DBTRG cancer cell lines. Compounds 1-8 were also found to possess significant antioxidant activities. Owing to these properties, this study can be further extended to explore more significant bioactive components of this plant.
    2,3',4,6-Tetrahydroxybenzophenone Description
    Source: The herbs of Garcinia cowa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0617 mL 20.3087 mL 40.6174 mL 81.2348 mL 101.5435 mL
    5 mM 0.8123 mL 4.0617 mL 8.1235 mL 16.247 mL 20.3087 mL
    10 mM 0.4062 mL 2.0309 mL 4.0617 mL 8.1235 mL 10.1543 mL
    50 mM 0.0812 mL 0.4062 mL 0.8123 mL 1.6247 mL 2.0309 mL
    100 mM 0.0406 mL 0.2031 mL 0.4062 mL 0.8123 mL 1.0154 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    FEBS Lett. 1997 Dec 29;420(2-3):143-6.
    Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L.[Pubmed: 9459298 ]

    METHODS AND RESULTS:
    The stepwise condensation of benzoyl-CoA with three molecules of malonyl-CoA, catalyzed by benzophenone synthase, yields 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by benzophenone 3'-hydroxylase, a cytochrome P450 monooxygenase. These biosynthetic steps, leading to the formation of 2,3',4,6-Tetrahydroxybenzophenone, represent an alternative pathway to that recently proposed for cell cultures of Centaurium erythraea [Peters et al., Planta (1997) in press].
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