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    Natural Products
    Puerol B
    Puerol B
    Information
    CAS No. 112343-17-6 Price $398 / 5mg
    Catalog No.CFN95155Purity>=98%
    Molecular Weight312.3Type of CompoundFlavonoids
    FormulaC18H16O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $338.3 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Regional Crop Research Institute (Korea)
  • Medical University of Gdansk (Poland)
  • Nanjing University of Chinese M... (China)
  • Universitas Airlangga (Indonesia)
  • Mahatma Gandhi University (India)
  • Centralised Purchases Unit (CPU... (India)
  • Seoul National University (Korea)
  • Istanbul University (Turkey)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Wollongong (Australia)
  • Sapienza University of Rome (Italy)
  • More...
  • Package
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    Puerol B

    Puerol B
    Product Name Puerol B
    CAS No.: 112343-17-6
    Catalog No.: CFN95155
    Molecular Formula: C18H16O5
    Molecular Weight: 312.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The stem barks of Sophora japonica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $398 / 5mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Flavonoids Compound Library
  • Biological Activity
    Description: (+/-)-Puerol B shows inhibitory activity on AGEs formation in vitro.
    In vitro:
    Arch Pharm Res. 2010 Oct;33(10):1651-4.
    Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity.[Pubmed: 21052940 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and Puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED(50) values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.
    Arch Pharm Res. 2006 Oct;29(10):821-5.
    Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs).[Pubmed: 17121174 ]

    METHODS AND RESULTS:
    Two isoflavone C-glucosides, puerarin (1) and PG-3 (2), a but-2-enolide, (+/-)-Puerol B (3), two isoflavone O-glucosides, daidzin (4) and genistin (5), and three pterocarpans, (-)-medicarpin (6), (-)-glycinol (7) and (-)-tuberosin (8), were isolated from a MeOH extract of the roots of Pueraria lobata, using an in vitro bioassay based on the inhibition of the formation of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1-8 were determined by spectroscopic data interpretation, particularly by 1D- and 2D-NMR studies, and by comparison of these data with values in the literature. All of the isolates (1-8) were evaluated for their inhibitory activity on AGEs formation in vitro.
    CONCLUSIONS:
    Of these, puerarin (1), PG-3 (2), and (+/-)-Puerol B (3) exhibited more potent inhibitory activity than the positive control aminoguanidine.
    Puerol B Description
    Source: The stem barks of Sophora japonica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
    5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
    10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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