ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Puerol B
Citing Use of our Products
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2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $338.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J Chem Inf Model....2021...Natural Product Res.&Deve....2022...ACS Omega2020, 5,33,20825-20830Nutrients.2021, 13(1):254. Plant Methods.2017, 13:108BMC Complement Altern Med....2018...Phytother Res.2019, 33(5):1490-1500J Med Food.2021, 24(3):209-217.
Appl. Sci.2020, 10(20),7374.Sci Rep.2020, 10:4495(2020)Molecules.2021, 26(2):313.J Sep Sci.2018, 41(11):2488-2497Bull. Natl. Mus. Nat. Sci....2021...Nutrients2022, 14(14)2929J Agric Food Chem....2021...Cytotechnology.2017, 69(5):765-773
Front Plant Sci.2017, 8:723Food Addit Contam Part A Chem Ana...2020...Sci Rep.2016, 6:25094Journal of Food Quality...2022...Environ Toxicol.2020, doi: 10.1002Antioxidants (Basel).2020, 9(2):E120Evid Based Complement Alternat Me...2021...
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Our products had been exported to the following research institutions and universities, And still growing.
University of Sao Paulo (Brazil)Lodz University of Technology (Poland)National Hellenic Research Foun... (Greece)University of Hertfordshire (United Kingdom)
Siksha O Anusandhan University (India)University of Dicle (Turkey)Nanjing University of Chinese M... (China)Complutense University of Madrid (Spain)
VIT University (India)Sri Ramachandra University (India)Copenhagen University (Denmark)
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Puerol B
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Nat Prod Commun.2017, 12(5):771-778Phytomedicine.2015, 22(11):1027-36J Insect Sci.2020, 20(5):18. Food Res Int.2018, 106:909-919Int J Cosmet Sci.2019, 41(1):12-20Acta Pharmaceutica Hungarica2016, 86:35-40Pharm Biol.2016, 54(7):1255-62Appl. Sci.2021, 11(24),12080Front Pharmacol.2018, 9:236Curr Top Med Chem.2020, 20(21):1898-1909.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
| Description: |
(+/-)-Puerol B shows inhibitory activity on AGEs formation in vitro. |
| In vitro: |
| Arch Pharm Res. 2010 Oct;33(10):1651-4. | | Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity.[Pubmed: 21052940 ] |
METHODS AND RESULTS:
Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and Puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED(50) values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds.
The structure of new compound 1 was determined using spectroscopic techniques. | | Arch Pharm Res. 2006 Oct;29(10):821-5. | | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs).[Pubmed: 17121174 ] |
METHODS AND RESULTS:
Two isoflavone C-glucosides, puerarin (1) and PG-3 (2), a but-2-enolide, (+/-)-Puerol B (3), two isoflavone O-glucosides, daidzin (4) and genistin (5), and three pterocarpans, (-)-medicarpin (6), (-)-glycinol (7) and (-)-tuberosin (8), were isolated from a MeOH extract of the roots of Pueraria lobata, using an in vitro bioassay based on the inhibition of the formation of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1-8 were determined by spectroscopic data interpretation, particularly by 1D- and 2D-NMR studies, and by comparison of these data with values in the literature. All of the isolates (1-8) were evaluated for their inhibitory activity on AGEs formation in vitro.
CONCLUSIONS:
Of these, puerarin (1), PG-3 (2), and (+/-)-Puerol B (3) exhibited more potent inhibitory activity than the positive control aminoguanidine. |
|
Puerol B Description
| Source: |
The stem barks of Sophora japonica. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.202 mL |
16.0102 mL |
32.0205 mL |
64.041 mL |
80.0512 mL |
| 5 mM |
0.6404 mL |
3.202 mL |
6.4041 mL |
12.8082 mL |
16.0102 mL |
| 10 mM |
0.3202 mL |
1.601 mL |
3.202 mL |
6.4041 mL |
8.0051 mL |
| 50 mM |
0.064 mL |
0.3202 mL |
0.6404 mL |
1.2808 mL |
1.601 mL |
| 100 mM |
0.032 mL |
0.1601 mL |
0.3202 mL |
0.6404 mL |
0.8005 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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