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    Natural Products
    2-Hydroxy-3-methoxybenzoic acid glucose ester
    2-Hydroxy-3-methoxybenzoic acid glucose ester
    Information
    CAS No. 172377-87-6 Price $268 / 5mg
    Catalog No.CFN89113Purity>=98%
    Molecular Weight330.28Type of CompoundPhenols
    FormulaC14H18O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $227.8 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    2-Hydroxy-3-methoxybenzoic acid glucose ester

    2-Hydroxy-3-methoxybenzoic acid glucose ester
    Product Name 2-Hydroxy-3-methoxybenzoic acid glucose ester
    CAS No.: 172377-87-6
    Catalog No.: CFN89113
    Molecular Formula: C14H18O9
    Molecular Weight: 330.28 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: PAFR
    Source: The whole plants of Gentiana scabra.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $268 / 5mg
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-platelet aggregation Compound Library
  • Antagonists Compound Library
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  • PAFR Inhibitor Library
  • Biological Activity
    Description: 2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
    Targets: PAFR
    In vivo:
    Arch Pharm Res. 1998 Aug;21(4):436-9.
    PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra.[Pubmed: 9875472]
    In order to find out anti-platelet activating factor (PAF) from natural resources, Korean medicinal plants used for the treatments of peripheral circulation disorders were tested for their possible protective effects on PAF-induced anaphylactic shock.
    METHODS AND RESULTS:
    From the above screening, the methanol extract of Gentiana scabra showed a potent antagonistic activity against PAF. Water suspension of the extract was partitioned with CH2Cl2 and EtOAc, successively. The EtOAc fraction which showed the highest activity was chromatographed on silica gel to yield 6 fractions. From the fraction which showed higher PAF-antagonistic activity than the other fractions, compound 1 was isolated by recrystallization.
    CONCLUSIONS:
    On the basis of spectral data, compound 1 was identified as 2-Hydroxy-3-methoxybenzoic acid glucose ester. The compound prevented the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
    2-Hydroxy-3-methoxybenzoic acid glucose ester Description
    Source: The whole plants of Gentiana scabra.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0277 mL 15.1387 mL 30.2773 mL 60.5547 mL 75.6934 mL
    5 mM 0.6055 mL 3.0277 mL 6.0555 mL 12.1109 mL 15.1387 mL
    10 mM 0.3028 mL 1.5139 mL 3.0277 mL 6.0555 mL 7.5693 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5139 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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