20R-Ginsenoside Rg2 | CAS:80952-72-3 | Manufacturer ChemFaces

20R-Ginsenoside Rg2

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Size /Price /Stock	10 mM * 1 mL in DMSO / $121.9 / In-stock
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Description:

Ginsenoside Rg2 may have a therapeutic potential for type 2 diabetic patients, it suppresses the hepatic glucose production via AMPK-induced phosphorylation of GSK3βand induction of SHP gene expression .Ginsenoside Rg2 can protect H9c2 cells against H2O2- induced injury through its actions of anti-oxidant and anti-apoptosis.20R-Ginsenoside Rg2 inhibits the cytokine interleukin 1 alpha (IL-1α)-induced reduction in gap junction-mediated intercellular communication (GJIC).

Targets:

GSK-3 | IL Receptor | AMPK

In vitro:

Planta Med., 2001, 67(5):417-22.

Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.[Pubmed: 11488454 ]

METHODS AND RESULTS:
In the present study we examined the effects of 27 ginsenosides isolated from Panax ginseng on GJIC. The results show that compounds 1 (oleanolic acid), 2 (ginsenoside-R0), 3 (ginsenoside-Rb1), 5 (ginsenoside-Rb2), 7 (ginsenoside-Rd), 8 (ginsenoside-Rg3), 12 (panaxadial), 13 (notoginsenoside-R4), 17 [ginsenoside-Rg2 (20S)], 18 (ginsenoside-Rf), and 26 (ginsenoside-F3) did not obviously affect GJIC, whereas compounds 4 (ginsenoside-Rc), 6 (ginsenoside-Rb3), 9 (ginsenoside-Rd2), 10 (notoginsenoside-Fe), 11 (ginsenoside-Rh2),14 (ginsenoside-Ra1), 15 (ginsenoside-Re), 16 (20R-Ginsenoside Rg2 ), 19 (ginsenoside-Ia), 20 [ginsenoside-Rh1 (20S)], 21 [ginsenoside-Rh1 (20R)], 22 (ginsenoside-F1), 23 (protopanaxatriol), 24 (panaxatriol), 25 (ginsenoside-Rg1), and 27 (chikusetsaponin-L8) induced GJIC reductions at various degrees. Compounds 2, 7, and 8 protected against the tyrosine phosphatase inhibitor vanadate-induced GJIC reduction, while compounds 1, 5, 7, and 17 inhibited the cytokine interleukin 1 alpha (IL-1alpha)-induced reduction in GJIC. Nevertheless, no compounds protected against the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced GJIC inhibition. On the other hand, GJIC reductions induced by compounds 6, 9,10, 20, 21, 22, 24, and 25 were inhibited by the tyrosine kinase (TK) inhibitor genistein, while GJIC reductions induced by compounds 6, 9, 14, 16, 19, 21, and 24 were attenuated in the presence of the PKC inhibitor calphostin C. However, GJIC reductions induced by compounds 4, 23, and 27 were not inhibited either by genistein or by calphostin C.
CONCLUSIONS:
These data indicate that various mechanisms are responsible for effects of ginsenosides on GJIC.

20R-Ginsenoside Rg2 Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	80952-72-3	Price	$218 / 20mg
Catalog No.	CFN90412	Purity	>=98%
Molecular Weight	785.02	Type of Compound	Triterpenoids
Formula	C₄₂H₇₂O₁₃	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	20R-Ginsenoside Rg2
CAS No.:	80952-72-3
Catalog No.:	CFN90412
Molecular Formula:	C₄₂H₇₂O₁₃
Molecular Weight:	785.02 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Targets:	GSK-3 \| IL Receptor \| AMPK
Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$218 / 20mg
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Cardioprotective Compound Library lowering hepatic gluconeogenesis Compound Library Anti-apoptotic Compound Library Triterpenoids Compound Library IL Receptor Inhibitor Library GSK-3 Inhibitor Library AMPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2739 mL	6.3693 mL	12.7385 mL	25.4771 mL	31.8463 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL	5.0954 mL	6.3693 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL	2.5477 mL	3.1846 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL	0.5095 mL	0.6369 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.2548 mL	0.3185 mL

CFN99968	Ginsenoside Rg2	52286-74-5	785.02	C₄₂H₇₂O₁₃
CFN99976	Ginsenoside Rf	52286-58-5	801.01	C₄₂H₇₂O₁₄
CFN95036	20-O-Glucoginsenoside Rf	68406-27-9	963.2	C₄₈H₈₂O₁₉
CFN92796	(20R)-Ginsenoside Rh1	80952-71-2	638.9	C₃₆H₆₂O₉
CFN90412	20R-Ginsenoside Rg2	80952-72-3	785.02	C₄₂H₇₂O₁₃
CFN90564	(20S)-Protopanaxatriol	34080-08-5	476.4	C₃₀H₅₂O₄
CFN99970	Ginsenoside Rh1	63223-86-9	638.88	C₃₆H₆₂O₉
CFN92364	Notoginsenoside R2	80418-25-3	771.0	C₄₁H₇₀O₁₃
CFN93373	20(R)-Notoginsenoside R2	948046-15-9	771.0	C₄₁H₇₀O₁₃
CFN92824	Notoginsenoside T5	769932-34-5	753.0	C₄₁H₆₈O₁₂