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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $475.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Vietnam Journal of Food Control....2022...Toxicol Res.2019, 35(4):371-387Cytotechnology2022, s10616The Journal of Phytopharmacology...2020...Viruses.2017, 9(10)Acta Chromatographica2021, 00960.J Cell Mol Med.2021, 25(5):2645-2654. Academic J of Second Military Med...2019...
Pharmacogn J.2022, 14(2):350-357J Vet Sci.2020, 21(3):e39.Am J Chin Med.2016, 44(6):1255-1271Chem Biol Interact.2016, 260:168-175Cell Mol Biol(Noisy-le-grand)...2019...Asian Pac J Cancer Prev....2019...J Nat Prod.2015, 78(6):1339-4J Nat Med.2017, 71(2):457-462
Cells.2021, 10(11):2919. Pharmaceuticals (Basel)....2020...Int J Mol Sci.2020, 21(7):2530.Applied Biological Chemistry ...2021...Food Chem.2020, 313:126079Molecules.2019, 24(11):E2102JEJU National University2022, 10478.
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Int J Biol Macromol.2019, 126:653-661Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36Cardiovasc Toxicol.2021, 21(11):947-963.Separations2021, 8(6),80.Drug Test Anal.2018, 10(10):1579-1589Int Immunopharmacol.2020, 90:107268.Mol Neurobiol.2021, 58(8):3665-3676. Saf Health Work.2019, 10(2):196-204Nat Prod Sci.2014, 20(3):182-190Vojnosanit Pregl2016, 75(00):391-391
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
|| Saucerneol has significant cardiovascular effects such as vasorelaxant and negative inotropic actions.|
|Planta Med 2008; 74(3): 233-238. |
|Cardiovascular Effects of Lignans Isolated from Saururus chinensis.[Reference: WebLink]|
|Saururus chinensis has been widely used as a traditional medicine for the treatment of beriberi, hypertension, pneumonia, edema, jaundice and gonorrhea. However, there is only limited information on the cardiovascular effects of S. chinensis extract or its single compounds. |
METHODS AND RESULTS:
The present study was performed to investigate the effects of active lignans isolated from the extract of S. chinensis on vascular responses and heart functions. The vasorelaxant activity-guided fractionation of roots extract of S. chinensis led to the isolation of eight lignans as active principles. These lignans produced concentration-dependent relaxations of the endothelium-intact aortic preparations of rat aorta. Particularly, Saucerneol (1), Saucerneol D (2) and machilin D (8) exhibited distinctive vasorelaxant activity (EC50 values: 2.2, 12.7 and 17.8 μM, respectively), which were significantly inhibited by removal of functional endothelium or pretreatment with N G-nitro-L-arginine methyl ester. Saucerneol (1) and Saucerneol D (2) caused a significant decrease in left ventricular pressure, +dP/dtmax and heart rate in isolated hearts.
These results suggest that several lignans including Saucerneol (1), Saucerneol D (2) and machilin D (8), isolated from the ethanol extract of the roots of S. chinensis, have significant cardiovascular effects such as vasorelaxant and negative inotropic actions.
||The herbs of Saururus chinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Tetrahedron Letters, 1983, 24( 45):4947-4950. |
|Manassantins A/B and saucerneol: novel biologically active lignoids from saururus cernuus.[Reference: WebLink]|
METHODS AND RESULTS:
From the extract of Saururus cernuus two toxic principles, manassantins A and B and a related substance, Saucerneol, were isolated.
They have novel dineolignan or sesquineolignan type structures. Although toxic, manassantin A showed potential neuroleptic activity.
|Advanced Materials Research,2011, Vols. 393-395 |
|Studies on Chemical Constituents from the Aerial Parts of Saururus chinensis.[Reference: WebLink]|
|To investigate into the active chemical constituents of Sanrurus chinensis．
METHODS AND RESULTS:
Repeated silica gel column chromatography was used in the isolation and purification; determination and spectral analysis were adopted to identify the chemical structures． Nineteen chemical compounds were isolated from the aerial parts of Saururus chinensis and identiﬁed as sauchinone (1),sauchinone A (2), licarin B (3),saucernetin(4), Saucerneol I(5), Kaemferol(6), Kaemferol- 3-O-rhamnopyranosyl(1→6)glucopyranoside(7), luteolin(8), quecretin (9), quecretin-7-O-β- D-glueopyranoside (10), quecretin-7-O -α-D-glueopyranoside (11), ursolic acid(12), ellagic acid(13), p-hydroxybenzoic acid(14), gallic acid(15), 3,4-dihydroxybenzoic acid (16) , caffeic acid(17), stearic acid (18) and β-sitosterol (19).
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