Saucerneol | CAS:88497-86-3 | Manufacturer ChemFaces

Saucerneol

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Description:

Saucerneol has significant cardiovascular effects such as vasorelaxant and negative inotropic actions.

In vitro:

Planta Med 2008; 74(3): 233-238.

Cardiovascular Effects of Lignans Isolated from Saururus chinensis.[Reference: WebLink]

Saururus chinensis has been widely used as a traditional medicine for the treatment of beriberi, hypertension, pneumonia, edema, jaundice and gonorrhea. However, there is only limited information on the cardiovascular effects of S. chinensis extract or its single compounds.
METHODS AND RESULTS:
The present study was performed to investigate the effects of active lignans isolated from the extract of S. chinensis on vascular responses and heart functions. The vasorelaxant activity-guided fractionation of roots extract of S. chinensis led to the isolation of eight lignans as active principles. These lignans produced concentration-dependent relaxations of the endothelium-intact aortic preparations of rat aorta. Particularly, Saucerneol (1), Saucerneol D (2) and machilin D (8) exhibited distinctive vasorelaxant activity (EC50 values: 2.2, 12.7 and 17.8 μM, respectively), which were significantly inhibited by removal of functional endothelium or pretreatment with N G-nitro-L-arginine methyl ester. Saucerneol (1) and Saucerneol D (2) caused a significant decrease in left ventricular pressure, +dP/dtmax and heart rate in isolated hearts.
CONCLUSIONS:
These results suggest that several lignans including Saucerneol (1), Saucerneol D (2) and machilin D (8), isolated from the ethanol extract of the roots of S. chinensis, have significant cardiovascular effects such as vasorelaxant and negative inotropic actions.

Saucerneol Description

Source:	The herbs of Saururus chinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Tetrahedron Letters, 1983, 24( 45):4947-4950.

Manassantins A/B and saucerneol: novel biologically active lignoids from saururus cernuus.[Reference: WebLink]

METHODS AND RESULTS:
From the extract of Saururus cernuus two toxic principles, manassantins A and B and a related substance, Saucerneol, were isolated.
CONCLUSIONS:
They have novel dineolignan or sesquineolignan type structures. Although toxic, manassantin A showed potential neuroleptic activity.

Advanced Materials Research,2011, Vols. 393-395

Studies on Chemical Constituents from the Aerial Parts of Saururus chinensis.[Reference: WebLink]

To investigate into the active chemical constituents of Sanrurus chinensis．
METHODS AND RESULTS:
Repeated silica gel column chromatography was used in the isolation and purification; determination and spectral analysis were adopted to identify the chemical structures． Nineteen chemical compounds were isolated from the aerial parts of Saururus chinensis and identiﬁed as sauchinone (1),sauchinone A (2), licarin B (3),saucernetin(4), Saucerneol I(5), Kaemferol(6), Kaemferol- 3-O-rhamnopyranosyl(1→6)glucopyranoside(7), luteolin(8), quecretin (9), quecretin-7-O-β- D-glueopyranoside (10), quecretin-7-O -α-D-glueopyranoside (11), ursolic acid(12), ellagic acid(13), p-hydroxybenzoic acid(14), gallic acid(15), 3,4-dihydroxybenzoic acid (16) , caffeic acid(17), stearic acid (18) and β-sitosterol (19).

CAS No.	88497-86-3	Price	$413 / 5mg
Catalog No.	CFN95267	Purity	>=95%
Molecular Weight	538.6	Type of Compound	Lignans
Formula	C₃₁H₃₈O₈	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Product Name	Saucerneol
CAS No.:	88497-86-3
Catalog No.:	CFN95267
Molecular Formula:	C₃₁H₃₈O₈
Molecular Weight:	538.6 g/mol
Purity:	>=95%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Saururus chinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$413 / 5mg
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8567 mL	9.2833 mL	18.5667 mL	37.1333 mL	46.4166 mL
5 mM	0.3713 mL	1.8567 mL	3.7133 mL	7.4267 mL	9.2833 mL
10 mM	0.1857 mL	0.9283 mL	1.8567 mL	3.7133 mL	4.6417 mL
50 mM	0.0371 mL	0.1857 mL	0.3713 mL	0.7427 mL	0.9283 mL
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.3713 mL	0.4642 mL

CFN98245	Vomifoliol	23526-45-6	224.3	C₁₃H₂₀O₃
CFN92782	Flavanthrin	120090-80-4	482.5	C₃₀H₂₆O₆
CFN99380	3-Methoxy-5-heneicosylphenol	126882-76-6	418.7	C₂₈H₅₀O₂
CFN90969	Tiglic acid	80-59-1	100.1	C₅H₈O₂