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    Natural Products
    23-O-Acetylshengmanol 3-O-beta-D-xyloside
    Information
    CAS No. 62498-88-8 Price
    Catalog No.CFN92970Purity>=98%
    Molecular Weight662.85Type of CompoundTriterpenoids
    FormulaC37H58O10Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    23-O-Acetylshengmanol 3-O-beta-D-xyloside

    23-O-Acetylshengmanol 3-O-beta-D-xyloside
    Product Name 23-O-Acetylshengmanol 3-O-beta-D-xyloside
    CAS No.: 62498-88-8
    Catalog No.: CFN92970
    Molecular Formula: C37H58O10
    Molecular Weight: 662.85 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: TNF-伪 | PPAR-纬 | ERK | PI3K | PKC
    Source: The herbs of Curculigo orchioides
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Sci Rep.2015, 5:13194
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Triterpenoids Compound Library
  • TNF-α Inhibitor Library
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  • ERK Inhibitor Library
  • Biological Activity
    Description: 23-O-Actylshengmanol-3-xyloside selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
    Targets: TNF-α | PPAR-γ | ERK | PI3K | PKC
    In vitro:
    Journal of Ethnopharmacology, 2011, 133(2):0-344.
    Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.[Reference: WebLink]
    The methanol extract of Cimicifugae Rhizome has been traditionally used in various disorders including inflammation.
    METHODS AND RESULTS:
    The aim of the study is to explore whether anti-inflammatory action of 3 active compounds, two triterpenoid glycosides (cimiside E, 23-O-actylshengmanol-3-xyloside(23-O-Acetylshengmanol 3-O-beta-D-xyloside)) and one furanocoumarin (isoimperatorin), isolated from Cimicifugae Rhizome is related with peroxisome proliferator-activated receptor-γ (PPAR-γ) expression in human umbilical endothelial cell line, EA.hy926 cells. Cell viability and production of reactive oxygen species were performed. In addition, adhesion of monocyte into endothelial cells and western blot for expression of adhesion molecules and signal proteins were investigated in tumor necrosis factor-α (TNF-α)-activated cells. Pretreatment of test compounds significantly reduced reactive oxygen species (ROS) production and expression of vascular cell adhesion molecule-1 (VCAM-1), but not intercellular cell adhesion molecule-1 (ICAM-1). Three compounds all dose-dependently increased not only PPAR-γ expression in EA.hy926 cells but inhibited TNF-α-induced phosphorylation of Akt, extracellular-signal-regulated kinase (ERK) and protein kinase C (PKC) with different specificity. Finally, they prevented TNF-α-induced adhesion of U937 monocytic cells to EA.hy926 cells.
    CONCLUSIONS:
    The present results show that cimiside E, 23-O-actylshengmanol-3-xyloside, isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
    23-O-Acetylshengmanol 3-O-beta-D-xyloside Description
    Source: The herbs of Curculigo orchioides
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5086 mL 7.5432 mL 15.0864 mL 30.1727 mL 37.7159 mL
    5 mM 0.3017 mL 1.5086 mL 3.0173 mL 6.0345 mL 7.5432 mL
    10 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.0173 mL 3.7716 mL
    50 mM 0.0302 mL 0.1509 mL 0.3017 mL 0.6035 mL 0.7543 mL
    100 mM 0.0151 mL 0.0754 mL 0.1509 mL 0.3017 mL 0.3772 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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