ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Food Chem.2020, 313:126079Cardiovasc Toxicol....2021...Korean Journal of Pharmacognosy...2018...Evid Based Complement Alternat Me...2017...Phytomedicine.2018, 47:48-57Acta Physiologiae Plantarum2016, 38:7J Med Food.2019, 22(10):1067-1077Appl Microbiol Biotechnol....2016...
Anticancer Res.2014, 34(7):3505-9Molecules.2016, 21(6)Int J Mol Sci.2019, 20(16):E4015Chem Biol Interact.2018, 290:44-51Appl. Sci.2020, 10(20),7374.Nutraceutical Research . ...2021...Antioxidants (Basel).2021, 10(1):112. ACS Omega.2021, 6(36):23460-23474.
Int J Mol Sci.2022, 23(1):538.Evid Based Complement Alternat Me...2020...J Applied Biological Chemistry...2021...Toxicological Research...2020...Horticulture Research2020, 7:111. Comput Biol Chem.2019, 83:107096Plants (Basel).2021, 10(11):2317.
Our products had been exported to the following research institutions and universities, And still growing.
Uniwersytet Medyczny w ?odzi (Poland)Universidad Veracuzana (Mexico)Ateneo de Manila University (Philippines)Weizmann Institute of Science (Israel)
University of Padjajaran (Indonesia)Wageningen University (Netherlands)University of Liège (Belgium)Subang Jaya Medical Centre (Malaysia)
Donald Danforth Plant Science C... (USA)Sri Ramachandra University (India)Melbourne University (Australia)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Sci Rep.2015, 5:13194Cancer Manag Res.2019, 11:483-500Sci Rep.2017, 7:40345J Drug Delivery Science and Tech.2022, 67:102957.Acta Edulis Fungi2020, 27(02):63-76.Arch Biochem Biophys.2020, 687:108384.J Ethnopharmacol.2017, 198:87-90Front Immunol. 2020, 11:62.Nutrients.2019, 11(4):E936SCOPUS.2020, 836-847.
Related Screening Libraries
|| 23-O-Actylshengmanol-3-xyloside selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.|
||TNF-α | PPAR-γ | ERK | PI3K | PKC|
|Journal of Ethnopharmacology, 2011, 133(2):0-344. |
|Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.[Reference: WebLink]|
|The methanol extract of Cimicifugae Rhizome has been traditionally used in various disorders including inflammation.
METHODS AND RESULTS:
The aim of the study is to explore whether anti-inflammatory action of 3 active compounds, two triterpenoid glycosides (cimiside E,
23-O-actylshengmanol-3-xyloside(23-O-Acetylshengmanol 3-O-beta-D-xyloside)) and one furanocoumarin (isoimperatorin), isolated from Cimicifugae Rhizome is related with peroxisome proliferator-activated receptor-γ (PPAR-γ) expression in human umbilical endothelial cell line, EA.hy926 cells. Cell viability and production of reactive oxygen species were performed. In addition, adhesion of monocyte into endothelial cells and western blot for expression of adhesion molecules and signal proteins were investigated in tumor necrosis factor-α (TNF-α)-activated cells. Pretreatment of test compounds significantly reduced reactive oxygen species (ROS) production and expression of vascular cell adhesion molecule-1 (VCAM-1), but not intercellular cell adhesion molecule-1 (ICAM-1). Three compounds all dose-dependently increased not only PPAR-γ expression in EA.hy926 cells but inhibited TNF-α-induced phosphorylation of Akt, extracellular-signal-regulated kinase (ERK) and protein kinase C (PKC) with different specificity. Finally, they prevented TNF-α-induced adhesion of U937 monocytic cells to EA.hy926 cells.
The present results show that cimiside E, 23-O-actylshengmanol-3-xyloside, isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
23-O-Acetylshengmanol 3-O-beta-D-xyloside Description
||The herbs of Curculigo orchioides
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.