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    Natural Products
    Columbianetin beta-D-glucopyranoside
    Columbianetin beta-D-glucopyranoside
    Information
    CAS No. 55836-35-6 Price $288 / 5mg
    Catalog No.CFN95038Purity>=98%
    Molecular Weight408.4Type of CompoundCoumarins
    FormulaC20H24O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $288 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Columbianetin beta-D-glucopyranoside

    Columbianetin beta-D-glucopyranoside
    Product Name Columbianetin beta-D-glucopyranoside
    CAS No.: 55836-35-6
    Catalog No.: CFN95038
    Molecular Formula: C20H24O9
    Molecular Weight: 408.4 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Targets: Immunology & Inflammation related
    Source: The roots of Angelica gigas
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $288 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Biosci Rep.2018, 38(4)
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • J Ethnopharmacol.2020, 269:113752.
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Biofactors.2018, 44(2):168-179
  • BMC Plant Biol.2020, 20(1):214.
  • Toxicol In Vitro.2019, 59:161-178
  • mBio.2020, 11(3):e00686-20.
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • HortTechnology2016, 26(6):816-819
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • Immunology & Inflammation related Inhibitor Library
  • Biological Activity
    Description: Columbianetin-beta-D-glucopyranoside exhibits anti-inflammatory and analgesic properties, it also shows strong inhibiting activity against platelet aggregation.
    Targets: Immunology & Inflammation related
    In vitro:
    Yao Xue Xue Bao. 1989;24(7):546-51.
    Studies of the active constituents of the Chinese drug [Pubmed: 2618698]

    METHODS AND RESULTS:
    Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and Columbianetin beta-D-glucopyranoside (VIII), by chemical and spectral analysis, compound VIII was isolated from plant for the first time.
    CONCLUSIONS:
    All these coumarins were tested on platelet aggregation induced by 2 microns ADP. I, II, III, IV and VIII showed strong inhibiting activity against platelet aggregation.
    Columbianetin beta-D-glucopyranoside Description
    Source: The roots of Angelica gigas
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4486 mL 12.2429 mL 24.4858 mL 48.9716 mL 61.2145 mL
    5 mM 0.4897 mL 2.4486 mL 4.8972 mL 9.7943 mL 12.2429 mL
    10 mM 0.2449 mL 1.2243 mL 2.4486 mL 4.8972 mL 6.1214 mL
    50 mM 0.049 mL 0.2449 mL 0.4897 mL 0.9794 mL 1.2243 mL
    100 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.4897 mL 0.6121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Pharm Biomed Anal. 2018 May 10;153:221-231.
    Simultaneous determination of columbianetin-β-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β-d-glucopyranoside metabolites by u[Pubmed: 29506005]
    Columbianetin beta-D-glucopyranoside (CBG) and its metabolite columbianetin (CBN) are the bioactive constituents of Angelicae pubescentis radix (APR). They exhibit the anti-platelet aggregation, anti-inflammatory and analgesic properties. The absorption, distribution, metabolism and excretion (ADME) of CBG has not been reported to date.
    METHODS AND RESULTS:
    Both high-performance liquid chromatography with fluorescence detection and ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry methods were developed and validated for the study of ADME of CBG. It was found that CBG could be catabolized into its active metabolite CBN in vivo. The absolute bioavailability of columbianetin-β-d-glucopyranoside was 5.63 ± 4.42%. The other co-existing constituents from the APR ethanol extract could enhance the absorption of CBG. CBG and CBN were rapidly and broadly distributed in the stomach, ovary, kidney, liver, spleen, lung, muscles, heart and brain. Higher levels of accumulation of CBG and CBN were detected in the ovary and kidney tissues. Eight metabolites of CBG were tentatively identified in blood, urine, bile and faeces of rats after oral administration of pure CBG. It was also found that CBG and CBN were mainly excreted through the faecal route.
    CONCLUSIONS:
    It can be concluded that the validated methods were successfully applied for absorption, distribution, metabolism and excretion study of CBG.
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