2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid | CAS:176983-21-4

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

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Product Name	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
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CAS No.:	176983-21-4
Catalog No.:	CFN89112
Molecular Formula:	C₃₀H₄₆O₅
Molecular Weight:	486.69 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The leaves of Eriobotrya japonica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Description:

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay of two-stage carcinogenesis on mouse skin.

Targets:

HIV

In vitro:

Phytochemistry. 2002 Feb;59(3):315-23.

Production of bioactive triterpenes by Eriobotrya japonica calli.[Pubmed: 11830140]

METHODS AND RESULTS:
Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt). Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid, hyptadienic acid and a mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid. The triterpene composition in the callus tissues was noticeably different from that in intact leaves. The contents of tormentic acid with antidiabetic action, and 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid with anti-HIV activity, were much larger than those in the intact leaves.
CONCLUSIONS:
All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid was the most potent inhibitor among them and caused a significant delay of two-stage carcinogenesis on mouse skin.

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid Description

Source:	The leaves of Eriobotrya japonica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Anti-tumor promoting activity Compound Library Triterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0547 mL	10.2735 mL	20.547 mL	41.0939 mL	51.3674 mL
5 mM	0.4109 mL	2.0547 mL	4.1094 mL	8.2188 mL	10.2735 mL
10 mM	0.2055 mL	1.0273 mL	2.0547 mL	4.1094 mL	5.1367 mL
50 mM	0.0411 mL	0.2055 mL	0.4109 mL	0.8219 mL	1.0273 mL
100 mM	0.0205 mL	0.1027 mL	0.2055 mL	0.4109 mL	0.5137 mL

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