ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $270.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Acta Physiologiae Plantarum...2015...SBRAS2016, 12Current Pharmaceutical Analysis...2017...Pharmacognosy Magazine...2017...Biochem Pharmacol.2017, 130:10-20J Chromatogr A.2017, 1518:46-58Anal Chim Acta.2018, 1039:162-171J Chromatogr B Analyt Technol Bio...2018...
Int J Mol Sci.2018, 19(9):E2528Chem Biol Interact.2018, 283:59-74Sci Rep.2018, 8(1)Front Microbiol.2019, 10:2806Molecules.2019, 24(17):E3127Korean J of Crop Science2019, 452-458Pharmacol Rep.2019, 71(2):289-298Biosci. Rep.2020, 10.1024
Sci Rep.2020, 10:4495(2020)J of App. Res. on Med&Aromatic Pl...2020...Neurotox Res.2020, 38(1):163-174.Korean Journal of Pharmacognosy....2020...Medicina (Kaunas).2020, 56(12):685.Antioxidants (Basel).2020, 9(11):1121.Indian J. of Experimental Bio....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Kazusa DNA Research Institute (Japan)Harvard University (USA)Universidad Industrial de Santa... (Colombia)Tokyo Woman's Christian University (Japan)
Korea Food Research Institute(K... (Korea)Kyushu University (Japan)Kamphaengphet Rajabhat University (Thailand)Lodz University of Technology (Poland)
Universidad de La Salle (Mexico)Monash University (Australia)Universidade da Beira Interior (Germany)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Chromatogr Sci.2020, 58(6):485-493.BMC Complement Altern Med.2014, 14:242Int J Mol Sci.2017, 19(1)Nutrients.2018, 10(12)Pharmacognosy Magazine2017, 13(52):868-874Chinese Journal of Hospital Pharmacy2020, 40(7)Evid Based Complement Alternat Med.2018, 2018:3610494J of L. Chroma.&Related Tech2017, 252-258Pharmaceutical Chemistry Journal2019, 52(12):986-991Appl. Sci.2021, 11(1),14.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
||3'-Hydroxy-5,7,4'-trimethoxyflavone posseses antioxidant and immunomodulatory effects.|
|J Pharm Pharmacol . 2015 Apr;67(4):597-604. |
|Zeyheria montana Mart. (Bignoniaceae) as source of antioxidant and immunomodulatory compounds with beneficial effects on intestinal inflammation[Pubmed: 25556766]|
|Objectives: Zeyheria montana is a medicinal plant used in Brazilian folk medicine for treating skin affections, ulcers, inflammation and diarrhoea, and as an antisyphilitic and antiblenorrhagic agent, but little is known about its mechanisms of action. Herein, a bio-guided assay was carried out to further evaluate its antioxidant and immunomodulatory effects, and the possible benefits on experimental intestinal inflammation.
Methods: Extracts, partitions, fractions and isolated compounds were tested for inhibition of lipid peroxidation. Isolated compounds were tested in vitro for its antioxidant and immunomodulatory action prior to in-vivo evaluation in trinitrobenzenesulfonic acid-induced rat colitis.
Key findings: Two major compounds were identified in the leaf dichloromethane extract: 3'-Hydroxy-5,7,4'-trimethoxyflavone and 6-hydroxy-5,7-dimethoxyflavone, which exhibited an antioxidant activity. The compounds protected the colonic glutathione levels in more than 90% despite the absence of protection against the gross macroscopic colonic damage. In addition, the compounds inhibited IL-1ß secretion by macrophages in 91.5% and 72.7% respectively, whereas both reduced IL-6 secretion in about 44.5%.
Conclusions: The major active compounds from Z. montana leaves exerted antioxidant and immunomodulatory effects, endorsing the use of Z. montana in folk medicine as an anti-inflammatory agent. However, further investigation is still needed regarding medicinal plants and the identification of candidate compounds for the treatment of the inflammatory bowel diseases.|
||The herbs of Callicarpa bodinieri
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Agric Food Chem . 2012 Aug 22;60(33):8123-8128. |
|Identification of 5,7,3',4'-tetramethoxyflavone metabolites in rat urine by the isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization-mass spectrometry[Pubmed: 22812915]|
|5,7,3',4'-Tetramethoxyflavone (TMF), one of the major polymethoxyflavones (PMFs) isolated from Kaempferia parviflor , has been reported possessing various bioactivities, including antifungal, antimalarial, antimycobacterial, and anti-inflammatory activities. Although several studies on the TMF have been reported, the information about the metabolism of TMF and the structures of TMF metabolites is still not yet clear. In this study, an isotope-labeling method was developed for the identification of TMF metabolites. Three isotope-labeled TMFs (5,7,3',4'-tetramethoxy[3'-D(3)]flavone, 5,7,3',4'-tetramethoxy[4'-D(3)]flavone, and 5,7,3',4'-tetramethoxy[5,4'-D(6)]flavone) were synthesized and administered to rats. The urine samples were collected, and the main metabolites were monitored by ultrahigh-performance liquid chromatography-electrospray ionization-mass spectrometry. Five TMF metabolites were unambiguously identified as 3'-Hydroxy-5,7,4'-trimethoxyflavone, 7-hydroxy-5,3',4'-trimethoxyflavone sulfate, 7-hydroxy-5,3',4'-trimethoxyflavone, 4'-hydroxy-5,7,3'-trimethoxyflavone, and 5-hydroxy-7,3',4'-trimethoxyflavone.|