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| Size /Price /Stock |
10 mM * 1 mL in DMSO / $109.4 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Plant Physiol Biochem.2019, 144:355-364Toxicol In Vitro.2022, 81:105346. Appl. Sci. 2021, 11(17),7829Journal of Research in Pharmacy....2022...Applied Biological Chemistry...2022...Food Res Int.2022, 157:111397.Phytomedicine.2021, 2(82):153452Biomed Chromatogr.2019, 8:e4774
Molecules. 2013, 18(11):14105-21Pharmaceutics.2020, 12(9):882. Sustainability2021, 13(23),12981.J Nat Med.2017, 71(4):745-756Acta horticulturae2017, 1158:257-268Int. J. Mol. Sci.2022, 23(14),7699; Oncotarget.2017, 8(53):90925-90947Evid Based Complement Alternat Me...2016...
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3-O-Caffeoylquinic acid methyl ester
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manager@chemfaces.com
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Rev. Chim.2020, 71(3),558-564Appl. Sci.2020, 10,1304Molecules.2016, 21(6)J Pharm Biomed Anal.2018, 151:32-41Front Plant Sci.2021, 12:673337.Int J Mol Sci.2021, 22(14):7324.Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.Korean Herb. Med. Inf.2021, 9(2):231-239.Ind Crops Prod.2014, 62:173-178Vietnam Journal of Food Control2022, 5(3):pp.390-401.
Related Screening Libraries
| Description: |
3-O-Caffeoylquinic acid methyl ester is a natural product from Morus alba L. |
| In vitro: |
| Planta Med. 2004 Aug;70(8):711-7. | | Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.[Pubmed: 15326547 ] | Anti-plasmodial activity-guided fractionation of Phlomis brunneogaleata (Lamiaceae) led to the isolation of two new metabolites, the iridoid glycoside, brunneogaleatoside and a new pyrrolidinium derivative (2 S,4 R)-2-carboxy-4-( E)- p-coumaroyloxy-1,1-dimethylpyrrolidinium inner salt [(2 S,4 R)-1,1-dimethyl-4-( E)- p-coumaroyloxyproline inner salt]. Moreover, a known iridoid glycoside, ipolamiide, six known phenylethanoid glycosides, verbascoside, isoverbascoside, forsythoside B, echinacoside, glucopyranosyl-(1-->G (i)-6)-martynoside and integrifolioside B, two flavone glycosides, luteolin 7- O-beta- D-glucopyranoside ( 10) and chrysoeriol 7- O-beta- D-glucopyranoside ( 11), a lignan glycoside liriodendrin, an acetophenone glycoside 4-hydroxyacetophenone 4- O-(6'- O-beta- D-apiofuranosyl)-beta- D-glucopyranoside and three caffeic acid esters, chlorogenic acid, 3-O-Caffeoylquinic acid methyl ester and 5- O-caffeoylshikimic acid were isolated.
METHODS AND RESULTS:
The structures of the pure compounds were elucidated by means of spectroscopic methods (UV, IR, MS, 1D and 2D NMR, [alpha] (D)) and X-ray crystallography. Compounds 10 and 11 were determined to be the major anti-malarial principles of the crude extract (IC (50) values of 2.4 and 5.9 micrograms/mL, respectively). They also exhibited significant leishmanicidal activity (IC (50) = 1.1 and 4.1 micrograms/mL, respectively). The inhibitory potential of the pure metabolites against plasmodial enoyl-ACP reductase (FabI), which is the key regulator of type II fatty acid synthases (FAS-II) in P. falciparum, was also assessed.
CONCLUSIONS:
Compound 10 showed promising FabI inhibiting effect (IC (50) = 10 micrograms/mL) and appears to be the first anti-malarial natural product targeting FabI of P. falciparum. |
|
3-O-Caffeoylquinic acid methyl ester Description
| Source: |
The fruits of Morus alba L |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7152 mL |
13.5759 mL |
27.1518 mL |
54.3036 mL |
67.8794 mL |
| 5 mM |
0.543 mL |
2.7152 mL |
5.4304 mL |
10.8607 mL |
13.5759 mL |
| 10 mM |
0.2715 mL |
1.3576 mL |
2.7152 mL |
5.4304 mL |
6.7879 mL |
| 50 mM |
0.0543 mL |
0.2715 mL |
0.543 mL |
1.0861 mL |
1.3576 mL |
| 100 mM |
0.0272 mL |
0.1358 mL |
0.2715 mL |
0.543 mL |
0.6788 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Yao Xue Xue Bao. 2014 Apr;49(4):504-6. | | Studies on chemical constituents from fruits of Morus alba L.[Pubmed: 24974468] | Chemical investigation of fruits of Mours alba L. lead to the isolation of fifteen compounds by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography.
METHODS AND RESULTS:
Their structures were determined to be: 1-[5-(2-formlfuryl) methyl] dihydrogen 2-hydroxypropane-1, 2, 3-tricarboxylate 2, 3-diethyl ester (1), 1-[2-(furan-2-yl)-2-oxoethyl] pyrrolidin-2-one (2), divaricataester A (3), methyl 1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylate (4), 1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylic acid (5), L-pyroglutamic acid (6), L-pyroglutamic acid ethyl ester (7), 3-O-Caffeoylquinic acid methyl ester (8), 3-O-caffeoylquinic acid ethyl ester (9), 5-O-caffeoylquinic acid methyl ester (10), 5-O-caffeoylquinic acid ethyl ester (11), 4-O-caffeoylquinic acid methyl ester (12), 4-O-caffeoylquinic acid methyl ester (13), 4-O-caffeoylquinic acid (14), 3-O-caffeoylquinic acid (15), respectively, based on the spectral analysis such as NMR, MS etc.
CONCLUSIONS:
Compounds 1-14 were isolated from this genus for the first time, among which 1 was a new compound. |
|
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