ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Beta-Dimorphecolic acid (9(S)-HODE)
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $222.6 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J. of Agricultural Science...2015...Molecules.2015, 20(11):20014-30Korean Journal of Pharmacognosy....2015...Evid Based Complement Alternat Me...2017...Evid Based Complement Alternat Me...2017...Biol Pharm Bull.2017, 40(6):797-806Nutrients.2018, 11(1):E17Pharmacognosy Magazine...2018...
The Journal of Agromedicine and M...2018...J Sep Sci.2018, 41(7):1682-1690J Adv Res.2019, 17:85-94BMC Complement Altern Med....2019...J of the Korean Society of Cosmet...2019...Planta Med.2019, 85(3):217-224J Ethnopharmacol.2020, 249:112381Research J. Pharm. and Tech....2020...
Int J Mol Sci.2020, 21(6):2190. Int J Mol Sci.2020, 21(7):2530.Molecules.2020, 25(11):2599. J Appl Toxicol.2020, 40(7):965-978.Korean J of Pharmacognosy...2020...Antioxidants (Basel).2020, 9(7):581.Ulm University Medical Center...2020...
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Our products had been exported to the following research institutions and universities, And still growing.
Max Rubner-Institut (MRI) (Germany)Warszawski Uniwersytet Medyczny (Poland)Sri Ramachandra University (India)Northeast Normal University Cha... (China)
University of Toulouse (France)Siksha O Anusandhan University (India)University of Vienna (Austria)Univerzita Karlova v Praze (Czech Republic)
Kazusa DNA Research Institute (Japan)University of British Columbia (Canada)Melbourne University (Australia)
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Beta-Dimorphecolic acid (9(S)-HODE)
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manager@chemfaces.com
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service@chemfaces.com
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+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Arch Toxicol.2017, 91(10):3225-3245J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417Appl. Sci.2020, 10,1304Journal of Apiculture2019, 34(2):131-136Molecules.2016, 21(6)J Pharmaceut Biomed2020, 178:112894Mol Cell.2017, 68(4):673-685LWT-Food Science and Technology2017, 75:488-496Biochem Pharmacol.2020, 178:114083J of Pharmaceutical Analysis2020, doi: 10.1016
Related Screening Libraries
| Description: |
Anti-inflammatory activity. |
| In vitro: |
| Pharmacogn Mag . Jul-Sep 2015;11(43):477-85 | | A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris[Pubmed: 26246722] | | Background: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities.
Objective: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE) from Cordyceps militaris and to evaluate their anti-inflammatory activities.
Materials and methods: Column chromatographic separation was performed and anti-inflammatory roles of these compounds were also examined by using NO production and protein kinase B (AKT) activity assays.
Results: From Cm-EE, 13 constituents, including trehalose (1), cordycepin (2), 6-hydroxyethyladenosine (3), nicotinic amide (4), butyric acid (5), β-dimorphecolic acid (6), α-dimorphecolic acid (7), palmitic acid (8), linoleic acid (9), cordycepeptide A (10), 4-(2-hydroxy-3-((9E,12E)-octadeca-9,12-dienoyloxy)propoxy)-2-(trimethylammonio)butanoate (11), 4-(2-hydroxy-3-(palmitoyloxy)propoxy)-2-(trimethylammonio)butanoate (12), and linoleic acid methyl ester (13) were isolated. Of these components, compound 2 displayed a significant inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW264.7 cells. Furthermore, this compound strongly and directly suppressed the kinase activity of AKT, an essential signalling enzyme in LPS-induced NO production, by interacting with its ATP binding site.
Conclusion: C. militaris could have anti-inflammatory activity mediated by cordycepin-induced suppression of AKT. |
|
Beta-Dimorphecolic acid (9(S)-HODE) Description
| Source: |
The herbs of Piper cubeba |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.3727 mL |
16.8634 mL |
33.7268 mL |
67.4536 mL |
84.317 mL |
| 5 mM |
0.6745 mL |
3.3727 mL |
6.7454 mL |
13.4907 mL |
16.8634 mL |
| 10 mM |
0.3373 mL |
1.6863 mL |
3.3727 mL |
6.7454 mL |
8.4317 mL |
| 50 mM |
0.0675 mL |
0.3373 mL |
0.6745 mL |
1.3491 mL |
1.6863 mL |
| 100 mM |
0.0337 mL |
0.1686 mL |
0.3373 mL |
0.6745 mL |
0.8432 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| ChemInform 63(32):7624-7633 | | Enantioselective syntheses of (-)-pinellic acid, α- and β-dimorphecolic acid[Reference: WebLink] | | An efficient enantioselective convergent approach for the synthesis of (−)-pinellic acid 1, α- and β-dimorphecolic acid (2 and 3) from 1,9-nonane diol is described. The synthetic strategy features Sharpless asymmetric hydroxylation, Sonogashira coupling and Birch reduction. |
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