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4,9-Dimethoxycanthin-6-one
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 4,9-Dimethoxycanthin-6-one
Price:
CAS No.: 1270001-72-3
Catalog No.: CFN92128
Molecular Formula: C16H12N2O3
Molecular Weight: 280.3 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 4,9-Dimethoxycanthin-6-one is a natural product from Ailanthus altissima.
In vitro:
Nat Prod Commun. 2010 Jan;5(1):17-22.
Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line.[Pubmed: 20184012]

METHODS AND RESULTS:
Phytochemical investigation of the stems of Eurycoma longifolia Jack led to the isolation of two new canthin-6-one alkaloids, 4,9-Dimethoxycanthin-6-one (1) and 10-hydroxy-11-methoxycanthin-6-one (2), and a new tirucallane-type triterpenoid, 23,24,25-trihydroxytirucall-7-en-3,6-dione (3), along with 37 known compounds. Among these, an oxasqualenoid (4) was isolated as a natural product for the first time. The structures of the isolates were elucidated by spectroscopic and mass spectrometric means. All the isolates were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma cell line.
CONCLUSIONS:
Among them, 9,10-dimethoxycanthin-6-one (14, IC50 = 5.0 microM), 10-hydroxy-9-methoxycanthin-6-one (15, IC50 = 7.2 microM), dihydroniloticin (18, IC50 = 8.2 microM), and 14-deacetyleurylene (34, IC50 = 3.2 microM) displayed stronger activity than the positive control 5-FU (IC50 = 9.2 microM).
4,9-Dimethoxycanthin-6-one Description
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5676 mL 17.838 mL 35.6761 mL 71.3521 mL 89.1902 mL
5 mM 0.7135 mL 3.5676 mL 7.1352 mL 14.2704 mL 17.838 mL
10 mM 0.3568 mL 1.7838 mL 3.5676 mL 7.1352 mL 8.919 mL
50 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.427 mL 1.7838 mL
100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.7135 mL 0.8919 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kukoamine A

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CAS No: 75288-96-9
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Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
Abietic acid

Catalog No: CFN90587
CAS No: 514-10-3
Price: $40/20mg
4',5,6,7-Tetramethoxyflavone

Catalog No: CFN91034
CAS No: 1168-42-9
Price: $258/5mg
Brucine

Catalog No: CFN90244
CAS No: 357-57-3
Price: $30/20mg
Eugenol

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D-(-)-Salicin

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Genipin

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Albiflorin

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