4'-Methoxyflavone | CAS:4143-74-2 | Manufacturer ChemFaces

4'-Methoxyflavone

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Description:

4'-Methoxyflavone can inhibit the modulation of the chemiluminescent capacity of macrophages.

In vitro:

Arzneimittel Forschung, 1995, 45(7):815-8.

Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives.[Reference: WebLink]

The effect of flavone (CAS 525-82-6, 2-phenylbenzopyran-4-one, 1), flavone-8-acetic acid (CSA 87626-55-9, FAA, 2) and 10 substituted flavones on the luminol-dependent chemiluminescence of murine macrophages was studied in vitro.
METHODS AND RESULTS:
The synthetic derivatives were variously substituted with halo, nitro, amino, hydroxy and methoxy substituents in the 3' and 4' positions. Chemiluminescence was used in this study as an indicator for the production of reactive oxygen species by macrophages, stimulated in vitro by phorbol myristate acetate (PMA). All flavones except FAA (2) showed more than 20% inhibition at 10 mumol/l or 100 mumol/l. 3'-Amino-4'-hydroxyflavone (8) was the most potent inhibitor. The IC50s for inhibition of chemiluminescence were 4.2 +/- 1.1 mumol/l, 5.0 +/- 1.0 mumol/l and 3.3 +/- 1.4 mumol/l for resident, elicited and LPS-Poly I:C-primed macrophages, respectively. Small but statistically significant enhancements of chemiluminescence were caused by low concentrations of flavone (1), FAA (2) and 4'-Methoxyflavone (6).
CONCLUSIONS:
These results suggest that modulation of the chemiluminescent capacity of macrophages depends on the nature of the substituents and the concentration of the flavones.

4'-Methoxyflavone Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
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PMID: 30417089

CAS No.	4143-74-2	Price
Catalog No.	CFN70361	Purity	>=98%
Molecular Weight	252.3	Type of Compound	Flavonoids
Formula	C₁₆H₁₂O₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	4'-Methoxyflavone
CAS No.:	4143-74-2
Catalog No.:	CFN70361
Molecular Formula:	C₁₆H₁₂O₃
Molecular Weight:	252.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9635 mL	19.8177 mL	39.6354 mL	79.2707 mL	99.0884 mL
5 mM	0.7927 mL	3.9635 mL	7.9271 mL	15.8541 mL	19.8177 mL
10 mM	0.3964 mL	1.9818 mL	3.9635 mL	7.9271 mL	9.9088 mL
50 mM	0.0793 mL	0.3964 mL	0.7927 mL	1.5854 mL	1.9818 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.7927 mL	0.9909 mL

CFN95396	3'-Hydroxy-5,7,4'-trimethoxyflavone	33554-52-8	328.3	C₁₈H₁₆O₆
CFN98234	Desmethoxycentaureidin	22934-99-2	330.3	C₁₇H₁₄O₇
CFN97418	Eupatorin	855-96-9	344.3	C₁₈H₁₆O₇
CFN70313	Eupatorin-5-methylether	21764-09-0	358.4	C₁₉H₁₈O₇
CFN98785	Chrysoeriol	491-71-4	300.3	C₁₆H₁₂O₆
CFN91826	4'-Methylchrysoeriol	4712-12-3	314.3	C₁₇H₁₄O₆
CFN98290	Velutin	25739-41-7	314.3	C₁₇H₁₄O₆
CFN95398	4'-Hydroxy-5,7,3'-trimethoxyflavone	1239-68-5	328.3	C₁₈H₁₆O₆
CFN90386	Jaceosidin	18085-97-7	330.29	C₁₇H₁₄O₇
CFN90418	Cirsilineol	41365-32-6	344.32	C₁₈H₁₆O₇