ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Auburn University2015, 1-58Proc Natl Acad Sci USA....2016...Analytical sci. & Tech2016, 186-193Mediators Inflamm.2016, 2016:7216912Phytochem Anal.2016, 27(5):296-303African J. Agricultural Research ...2017...Invest New Drugs.2017, 35(2):166-179Oncotarget.2017, 9(3):4161-4172
Nutrients.2018, 10(10)Nat Prod Commun.2018, 10.1177PLoS One.2018, 13(4):e0195642Korean Journal of Pharmacognosy...2018...Planta Med.2018, 84(15):1101-1109Cell Death Dis.2019, 10(12):882Clin Transl Oncol.2019, 10.1007Front Neurosci.2019, 13:1091
Environ Toxicol.2019, 34(12):1354-1362Phytomedicine.2019, 58:152893Phytomedicine.2019, 61:152813Ann Transl Med.2019, 7(23):731United States Patent Application...2020...Biosci Biotechnol Biochem....2020...Biochem Pharmacol.2020, 178:114083
Our products had been exported to the following research institutions and universities, And still growing.
CSIRO - Agriculture Flagship (Australia)University of Fribourg (Switzerland)Institute of Pathophysiology Me... (Austria)Griffith University (Australia)
University of Dicle (Turkey)Deutsches Krebsforschungszentrum (Germany)Universidad de Ciencias y Artes... (Mexico)Uniwersytet Gdański (Poland)
Michigan State University (USA)Srinakharinwirot University (Thailand)FORTH-IMBB (Greece)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Phytomedicine.2019, 62:152962Anat Rec2018, 24264Toxicological Research2020, doi: 10.1007.Oxid Med Cell Longev2019, 9056845:13Food Engineering Progress2019, 23(3)209-216The Korea Society of Pha.2014, 300-314J Food Sci Technol.2019, 56(5):2712-2720Biosci Biotechnol Biochem.2020, 84(3):621-632PLoS One.2020, 15(2):e0220084.Sci Rep.2015, 5:13194
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
||4'-Methoxyflavone can inhibit the modulation of the chemiluminescent capacity of macrophages.|
| Arzneimittel Forschung, 1995, 45(7):815-8. |
|Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives.[Reference: WebLink]|
|The effect of flavone (CAS 525-82-6, 2-phenylbenzopyran-4-one, 1), flavone-8-acetic acid (CSA 87626-55-9, FAA, 2) and 10 substituted flavones on the luminol-dependent chemiluminescence of murine macrophages was studied in vitro.
METHODS AND RESULTS:
The synthetic derivatives were variously substituted with halo, nitro, amino, hydroxy and methoxy substituents in the 3' and 4' positions. Chemiluminescence was used in this study as an indicator for the production of reactive oxygen species by macrophages, stimulated in vitro by phorbol myristate acetate (PMA). All flavones except FAA (2) showed more than 20% inhibition at 10 mumol/l or 100 mumol/l. 3'-Amino-4'-hydroxyflavone (8) was the most potent inhibitor. The IC50s for inhibition of chemiluminescence were 4.2 +/- 1.1 mumol/l, 5.0 +/- 1.0 mumol/l and 3.3 +/- 1.4 mumol/l for resident, elicited and LPS-Poly I:C-primed macrophages, respectively. Small but statistically significant enhancements of chemiluminescence were caused by low concentrations of flavone (1), FAA (2) and 4'-Methoxyflavone (6).
These results suggest that modulation of the chemiluminescent capacity of macrophages depends on the nature of the substituents and the concentration of the flavones.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.