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    Natural Products
    4'-Methoxyflavone
    4'-Methoxyflavone
    Information
    CAS No. 4143-74-2 Price
    Catalog No.CFN70361Purity>=98%
    Molecular Weight252.3Type of CompoundFlavonoids
    FormulaC16H12O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    4'-Methoxyflavone

    4'-Methoxyflavone
    Product Name 4'-Methoxyflavone
    CAS No.: 4143-74-2
    Catalog No.: CFN70361
    Molecular Formula: C16H12O3
    Molecular Weight: 252.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Flavonoids Compound Library
  • Biological Activity
    Description: 4'-Methoxyflavone can inhibit the modulation of the chemiluminescent capacity of macrophages.
    In vitro:
    Arzneimittel Forschung, 1995, 45(7):815-8.
    Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives.[Reference: WebLink]
    The effect of flavone (CAS 525-82-6, 2-phenylbenzopyran-4-one, 1), flavone-8-acetic acid (CSA 87626-55-9, FAA, 2) and 10 substituted flavones on the luminol-dependent chemiluminescence of murine macrophages was studied in vitro.
    METHODS AND RESULTS:
    The synthetic derivatives were variously substituted with halo, nitro, amino, hydroxy and methoxy substituents in the 3' and 4' positions. Chemiluminescence was used in this study as an indicator for the production of reactive oxygen species by macrophages, stimulated in vitro by phorbol myristate acetate (PMA). All flavones except FAA (2) showed more than 20% inhibition at 10 mumol/l or 100 mumol/l. 3'-Amino-4'-hydroxyflavone (8) was the most potent inhibitor. The IC50s for inhibition of chemiluminescence were 4.2 +/- 1.1 mumol/l, 5.0 +/- 1.0 mumol/l and 3.3 +/- 1.4 mumol/l for resident, elicited and LPS-Poly I:C-primed macrophages, respectively. Small but statistically significant enhancements of chemiluminescence were caused by low concentrations of flavone (1), FAA (2) and 4'-Methoxyflavone (6).
    CONCLUSIONS:
    These results suggest that modulation of the chemiluminescent capacity of macrophages depends on the nature of the substituents and the concentration of the flavones.
    4'-Methoxyflavone Description
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9635 mL 19.8177 mL 39.6354 mL 79.2707 mL 99.0884 mL
    5 mM 0.7927 mL 3.9635 mL 7.9271 mL 15.8541 mL 19.8177 mL
    10 mM 0.3964 mL 1.9818 mL 3.9635 mL 7.9271 mL 9.9088 mL
    50 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.5854 mL 1.9818 mL
    100 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.7927 mL 0.9909 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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