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1. Reference standards
2. Pharmacological research
3. Inhibitors
4'-Methoxyflavone
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
PLoS One.2018, 13(4):e0195642Phytomedicine.2018, 47:48-57J Cell Mol Med....2020...Evid Based Complement Alternat Me...2022...Phytomedicine.2019, 57:95-104Front Pharmacol.2022, 13:906763.Nat Prod Commun.2014, 9(5):679-82Cell.2022, 185(23):4298-4316.e21.
Curr Res Virol Sci.2022, 3:100019.Food Res Int.2018, 106:909-919Nutrients.2018, 10(12)Free Radic Biol Med.2021, 166:104-115.J Nat Med.2021, doi: 10.1007.Int J Mol Sci.2017, 18(5)Int. J. Mol. Sci.2022, 23(14),7699; Biomed Pharmacother.2019, 116:108987
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4'-Methoxyflavone
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+86-27-84254680
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Nutrients.2018, 10(7)The Catharanthus Genome2022,35-83.Front Immunol.2020, 11:598556.Process Biochemistry2019, 85:106-115Foods.2022, 12(1):136. Biomedicines.2022, 10(3):583.Molecules 2021, 26(4),1092.Industrial Crops and Products2022, 186:115298J Cell Physiol.2021, 236(3):1950-1966.J Ethnopharmacol.2018, 210:88-94
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
Description: |
4'-Methoxyflavone can inhibit the modulation of the chemiluminescent capacity of macrophages. |
In vitro: |
Arzneimittel Forschung, 1995, 45(7):815-8. | Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives.[Reference: WebLink] | The effect of flavone (CAS 525-82-6, 2-phenylbenzopyran-4-one, 1), flavone-8-acetic acid (CSA 87626-55-9, FAA, 2) and 10 substituted flavones on the luminol-dependent chemiluminescence of murine macrophages was studied in vitro.
METHODS AND RESULTS:
The synthetic derivatives were variously substituted with halo, nitro, amino, hydroxy and methoxy substituents in the 3' and 4' positions. Chemiluminescence was used in this study as an indicator for the production of reactive oxygen species by macrophages, stimulated in vitro by phorbol myristate acetate (PMA). All flavones except FAA (2) showed more than 20% inhibition at 10 mumol/l or 100 mumol/l. 3'-Amino-4'-hydroxyflavone (8) was the most potent inhibitor. The IC50s for inhibition of chemiluminescence were 4.2 +/- 1.1 mumol/l, 5.0 +/- 1.0 mumol/l and 3.3 +/- 1.4 mumol/l for resident, elicited and LPS-Poly I:C-primed macrophages, respectively. Small but statistically significant enhancements of chemiluminescence were caused by low concentrations of flavone (1), FAA (2) and 4'-Methoxyflavone (6).
CONCLUSIONS:
These results suggest that modulation of the chemiluminescent capacity of macrophages depends on the nature of the substituents and the concentration of the flavones. |
|
4'-Methoxyflavone Description
Source: |
|
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
3.9635 mL |
19.8177 mL |
39.6354 mL |
79.2707 mL |
99.0884 mL |
5 mM |
0.7927 mL |
3.9635 mL |
7.9271 mL |
15.8541 mL |
19.8177 mL |
10 mM |
0.3964 mL |
1.9818 mL |
3.9635 mL |
7.9271 mL |
9.9088 mL |
50 mM |
0.0793 mL |
0.3964 mL |
0.7927 mL |
1.5854 mL |
1.9818 mL |
100 mM |
0.0396 mL |
0.1982 mL |
0.3964 mL |
0.7927 mL |
0.9909 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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