ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $71.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Phytochemistry Letters2015, 243-247Inflammation.2015, 38(4):1502-16Food Sci Biotechnol....2016...Chem Biol Interact.2016, 258:59-68Molecules.2017, 22(11)Journal of Functional Foods...2017...J Nat Prod.2017, 80(4):854-863Evid Based Complement Alternat Me...2018...
Korean J of Medicinal Crop Scienc...2018...Academic J of Second Military Med...2018...Front Plant Sci.2018, 9:1424J Mol Med (Berl).2018, 96(7):661-672J Chromatogr B Analyt Technol Bio...2019...Food and Agriculture Org. Of the ...2019...Int J Mol Sci.2019, 20(21):E5488Exp Biol Med (Maywood)....2019...
Food Chem.2019, 274:345-350Food Sci Nutr.2019, 8(1):246-256Appl. Sci.2020, 10(4),1304Biochem Pharmacol. 2020, 177:114014.Biochem Biophys Res Commun....2020...Plants (Basel).2020, 9(11):1555.Antioxidants (Basel).2020, 9(6):526.
Our products had been exported to the following research institutions and universities, And still growing.
Biotech R&D Institute (USA)Instituto Politécnico de Bragan?a (Portugal)University of Maryland School o... (USA)University of Perugia (Italy)
Monash University Sunway Campus (Malaysia)Research Unit Molecular Epigene... (Germany)Utrecht University (Netherlands)Mahidol University (Thailand)
CSIRO - Agriculture Flagship (Australia)University of Melbourne (Australia)University of Hertfordshire (United Kingdom)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Nutrients.2018, 10(12)Food Funct.2020, 10.1039Nutr Res Pract2019, 13:e45TCI CO.2019, US20190151281A1Pak J Pharm Sci.2018, 31:311-315Pathogens.2018, 7(3):E62Asian Pac J Cancer Prev. 2020, 21(4):935-941. Antioxidants (Basel).2020, 9(4):326. Biochem Biophys Res Commun.2020, 527(4):889-895.International J of Green Pharmacy2019, 13(3)
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Chalcones Compound Library
|| Reference standards.|
|Journal of Natural Products,2018, 81(4):966-975. |
|Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.[Pubmed: 29641206]|
|Postmenopausal women are increasingly using botanicals for menopausal symptom relief due to the increased breast cancer risk associated with traditional estrogen therapy. The deleterious effects of estrogens are associated with estrogen receptor (ER)α-dependent proliferation, while ERβ activation could enhance safety by opposing ERα effects.
METHODS AND RESULTS:
Three medicinal licorice species, Glycyrrhiza glabra ( G. glabra), G. uralensis, and G. inflata, were studied for their differential estrogenic efficacy. The data showed higher estrogenic potency for G. inflata in an alkaline phosphatase induction assay in Ishikawa cells (ERα) and an estrogen responsive element (ERE)-luciferase assay in MDA-MB-231/β41 breast cancer cells (ERβ). Bioassay-guided fractionation of G. inflata led to the isolation of 8-prenylapigenin (3). Surprisingly, a commercial batch of 3 was devoid of estrogenic activity. Quality control by MS and qNMR revealed an incorrect compound, 4'- O-methylbroussochalcone B (10), illustrating the importance of both structural and purity verification prior to any biological investigations. Authentic and pure 3 displayed 14-fold preferential ERβ agonist activity. Quantitative analyses revealed that 3 was 33 times more concentrated in G. inflata compared to the other medicinal licorice extracts.
These data suggest that standardization of G. inflata to 3 might enhance the safety and efficacy of G. inflata supplements used for postmenopausal women's health.
4'-O-Methylbroussochalcone B Description
||The seeds of Psoralea corylifolia Linn.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.