4-Quinazolinone | CAS:491-36-1 | Manufacturer ChemFaces

4-Quinazolinone

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Description:

Some 4-quinazolinone derivatives have antiplatelet activity.

In vitro:

Pharmazie. 1992 Feb;47(2):91-4.

Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives.[Pubmed: 1635928]

METHODS AND RESULTS:
Some new 4-Quinazolinones were prepared. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by ADP, collagen, arachidonic acid and the platelet serotonin release reaction.
CONCLUSIONS:
Most molecules showed an inhibiting power similar to that of acetylsalicylic acid under the same conditions, and even greater when aggregation was induced by ADP. Reduction of the 4-Quinazolinone derivatives to their 1,2,3,4-tetrahydroquinazoline homologues produced an increase in platelet inhibitory action except when ADP is the inductor.

4-Quinazolinone Description

Source:	The roots of Dichroa febrifuga
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	4-Quinazolinone
Price:
CAS No.:	491-36-1
Catalog No.:	CFN91938
Molecular Formula:	C₈H₆N₂O
Molecular Weight:	146.15 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Dichroa febrifuga
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.8423 mL	34.2114 mL	68.4229 mL	136.8457 mL	171.0571 mL
5 mM	1.3685 mL	6.8423 mL	13.6846 mL	27.3691 mL	34.2114 mL
10 mM	0.6842 mL	3.4211 mL	6.8423 mL	13.6846 mL	17.1057 mL
50 mM	0.1368 mL	0.6842 mL	1.3685 mL	2.7369 mL	3.4211 mL
100 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.3685 mL	1.7106 mL

CFN98773	Vasicinone	486-64-6	202.2	C₁₁H₁₀N₂O₂
CFN97406	Vasicinolone	84847-50-7	218.2	C₁₁H₁₀N₂O₃
CFN98889	Coixol	532-91-2	165.1	C₈H₇NO₃
CFN97184	2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one	69804-59-7	181.1	C₈H₇NO₄
CFN89192	Arborine	6873-15-0	250.30	C₁₆H₁₄N₂O
CFN92302	Febrifugine	24159-07-7	301.3	C₁₆H₁₉N₃O₃
CFN92303	Isofebrifugine	32434-44-9	301.3	C₁₆H₁₉N₃O₃
CFN91939	Desoxypeganine	495-59-0	172.23	C₁₁H₁₂N₂
CFN97052	Vasicine	6159-55-3	188.2	C₁₁H₁₂N₂O
CFN99009	Vasicinol	5081-51-6	204.2	C₁₁H₁₂N₂O₂