Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    6,7-Dihydroxyflavone
    6,7-Dihydroxyflavone
    Information
    CAS No. 38183-04-9 Price $118 / 20mg
    Catalog No.CFN70351Purity>=98%
    Molecular Weight254.2Type of CompoundFlavonoids
    FormulaC15H10O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $34.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Centralised Purchases Unit (CPU... (India)
  • University of Melbourne (Australia)
  • Tokyo Woman's Christian University (Japan)
  • Subang Jaya Medical Centre (Malaysia)
  • Srinakharinwirot University (Thailand)
  • Sri Sai Aditya Institute of Pha... (India)
  • Utrecht University (Netherlands)
  • University of Parma (Italy)
  • Universidad de Antioquia (Colombia)
  • University of Illinois at Chicago (USA)
  • More...
  • Package
    Featured Products
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Gomisin N

    Catalog No: CFN90125
    CAS No: 69176-52-9
    Price: $288/20mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $/mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    3,5-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90857
    CAS No: 159934-13-1
    Price: $388/5mg
    3-Epioleanolic acid

    Catalog No: CFN92068
    CAS No: 25499-90-5
    Price: $318/10 mg

    6,7-Dihydroxyflavone

    6,7-Dihydroxyflavone
    Product Name 6,7-Dihydroxyflavone
    CAS No.: 38183-04-9
    Catalog No.: CFN70351
    Molecular Formula: C15H10O4
    Molecular Weight: 254.2 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The roots of Pueraria lobata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $118 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • J Nat Med.2018, 72(3):734-744
  • Antioxidants (Basel).2021, 10(1):112.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Phytomedicine.2021, 93:153796.
  • J Biol Chem.2014, 289(3):1723-31
  • Appl. Sci.2020, 10,1304
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Life Sci.2021, 286:120019.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Flavonoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: 6,7-Dihydroxyflavone has fee radical scavenging activity. 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA).
    Targets: Antifection
    In vitro:
    Quantitative Structure Activity Relationships, 2000, 19(1):50-53.
    Theoretical Investigation on Free Radical Scavenging Activity of 6,7‐Dihydroxyflavone.[Reference: WebLink]

    METHODS AND RESULTS:
    The difference of heat of formation between parent molecule and its free radical (ΔHOF), calculated by semiempirical quantum chemical method AM1, was employed as a theoretical index to characterize the O–H bond dissociation energy (BDE) of antioxidant. Through a comparison between ΔHOF of model molecules, it was found that 6,7‐dihydroxyflavone (DHF) possessed two favorable structural factors, the presence of ortho hydroxyls and the existence of para oxygen, to weaken its O–H bond at position 6, but the passive effect produced by electron‐withdrawing property of the chromonoid ring C surpassed the active effect of the para oxygen. Therefore the free radical scavenging activity of DHF was lower than that of quercetin which possessed catecholic hydroxyl in ring B and was scarcely influenced by ring C.
    CONCLUSIONS:
    As a result of the analysis, two more active flavonoid antioxidants were constructed theoretically.
    Antimicrobial Agents and Chemotherapy, 01 Apr 2004, 48(4):1357-1360.
    6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to -Lactams.[Reference: WebLink]

    METHODS AND RESULTS:
    We have demonstrated that 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.
    6,7-Dihydroxyflavone Description
    Source: The roots of Pueraria lobata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    3,7,23,24-tetrahydroxycucurbita-5,...

    Catalog No: CFN95168
    CAS No: 1446447-97-7
    Price: $318/5mg
    4-Hydroxybenzoyl choline

    Catalog No: CFN95158
    CAS No: 5094-31-5
    Price: $318/20mg
    Rhamnetin 3-galactoside

    Catalog No: CFN95116
    CAS No: 62858-07-5
    Price: $318/5mg
    Pd-C-II

    Catalog No: CFN95003
    CAS No: N/A
    Price: $358/5mg
    8'-O-(3-hydroxy-3-methylglutaryl)-...

    Catalog No: CFN95308
    CAS No: 69790-31-4
    Price: $318/5mg
    Quercetin 7-O-(6''-O-malonyl)-beta...

    Catalog No: CFN95208
    CAS No: 98767-37-4
    Price: $388/5mg
    Microgrewiapine A

    Catalog No: CFN95125
    CAS No: 1420777-30-5
    Price: $413/5mg
    (1S,2S)-threo-Honokitriol

    Catalog No: CFN95076
    CAS No: 1099687-80-5
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
    5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
    10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
    50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
    100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Gomisin N

    Catalog No: CFN90125
    CAS No: 69176-52-9
    Price: $288/20mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $/mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    3,5-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90857
    CAS No: 159934-13-1
    Price: $388/5mg
    3-Epioleanolic acid

    Catalog No: CFN92068
    CAS No: 25499-90-5
    Price: $318/10 mg