DL-Syringaresinol | CAS:1177-14-6 | Manufacturer ChemFaces

DL-Syringaresinol

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Description:

(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.

Targets:

Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO

In vitro:

Biol Pharm Bull. 2006 Jan;29(1):172-3.

Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533]

METHODS AND RESULTS:
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.

Int Immunopharmacol. 2008 Jul;8(7):967-73.

(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]

METHODS AND RESULTS:
The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
CONCLUSIONS:
These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.

DL-Syringaresinol Description

Source:	The herbs of Liriodendron tulipifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	1177-14-6	Price
Catalog No.	CFN99276	Purity	>=98%
Molecular Weight	418.4	Type of Compound	Lignans
Formula	C₂₂H₂₆O₈	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	DL-Syringaresinol
CAS No.:	1177-14-6
Catalog No.:	CFN99276
Molecular Formula:	C₂₂H₂₆O₈
Molecular Weight:	418.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Targets:	Antifection \| PI3K \| Akt \| Calcium Channel \| NOS \| HIF \| NO
Source:	The herbs of Liriodendron tulipifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antibacterial Compound Library Cardioprotective Compound Library Vasorelaxation Compound Library Lignans Compound Library PI3K Inhibitor Library NOS Inhibitor Library NO Inhibitor Library HIF Inhibitor Library Calcium Channel Inhibitor Library Antifection Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3901 mL	11.9503 mL	23.9006 mL	47.8011 mL	59.7514 mL
5 mM	0.478 mL	2.3901 mL	4.7801 mL	9.5602 mL	11.9503 mL
10 mM	0.239 mL	1.195 mL	2.3901 mL	4.7801 mL	5.9751 mL
50 mM	0.0478 mL	0.239 mL	0.478 mL	0.956 mL	1.195 mL
100 mM	0.0239 mL	0.1195 mL	0.239 mL	0.478 mL	0.5975 mL

CFN99618	De-4'-O-methylyangambin	149250-48-6	432.5	C₂₃H₂₈O₈
CFN96717	Episyringaresinol	51152-20-6	418.44	C₂₂H₂₆O₈
CFN99276	DL-Syringaresinol	1177-14-6	418.4	C₂₂H₂₆O₈
CFN92060	Syringaresinol	487-35-4	418.4	C₂₂H₂₆O₈
CFN98009	Syringaresinol diacetate	1990-77-8	502.5	C₂₆H₃₀O₁₀
CFN97220	Acanthoside B	7374-79-0	580.6	C₂₈H₃₆O₁₃
CFN90458	Syringaresinol-di-O-glucoside	66791-77-3	742.71	C₃₄H₄₆O₁₈
CFN98964	Liriodendrin	573-44-4	742.7	C₃₄H₄₆O₁₈