ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Sci. 2014, 15(5):8443-57Mol Cells.2015, 38(9):765-72J Exp Bot.2016, 67(12):3777-88Nutrients.2017, 10(1)J Nat Med.2017, 71(2):457-462LWT-Food Science and Technology...2017...Sci Rep. 2017, 8207(7)J of Engineering Science&Technolo...2018...
The Pharmaceutical Society of Jap...2018...Front Pharmacol.2019, 10:1226Front Pharmacol.2019, 10:1355Drug Invention Today...2019...Plant Physiol Biochem.2019, 144:355-364BMC Complement Altern Med....2019...Molecules.2019, 24(21):E3834Molecules.2019, 24(9):E1719
Metabolites.2019, 9(11):E271Br J Pharmacol.2020, 10.1111J Ethnopharmacol.2020, 249:112396Food Res Int.2020, 133:109130.Oxid Med Cell Longev....2020...Institut Pasteur Korea...2020...Phytochemistry.2021, 181:112539.
Our products had been exported to the following research institutions and universities, And still growing.
Medical University of Gdansk (Poland)Tokyo Woman's Christian University (Japan)University of Maryland (USA)Sant Gadge Baba Amravati Univer... (India)
University of Limpopo (South Africa)Universiti Malaysia Pahang (Malaysia)National Research Council of Ca... (Canada)University of Liège (Belgium)
Osmania University (India)Utah State University (USA)Chungnam National University (Korea)
Related Screening Libraries
||(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. |
||Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO|
|Biol Pharm Bull. 2006 Jan;29(1):172-3. |
|Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533]|
METHODS AND RESULTS:
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.
|Int Immunopharmacol. 2008 Jul;8(7):967-73. |
|(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]|
METHODS AND RESULTS:
The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.
||The herbs of Liriodendron tulipifera
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chemische Berichte,1965,98(2):538–539. |
|Isolierung von DL-Syringaresinol aus Buchenholz[Reference: WebLink]|
METHODS AND RESULTS:
Bei der Perkolation von Buchenholz mit 2-proz. Essigsäure in der Hitze geht das Buchenlignin teilweise in Lösung. Unter den im Extrakt vorkommenden niedermolekularen Phenolen findet sich DL-Syringaresinol.