ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
PLoS One.2022, 17(4):e0267007. Food and Agriculture Org. Of the ...2019...J. of Agricultural Science...2015...Toxicol In Vitro.2018, 52:94-105Plant Foods Hum Nutr.2020, 10.1007Food Control2022, 132:108434.Nutrients.2017, 10(1)J Agric Food Chem....2019...
South African J of Botany...2020...Korean J. Medicinal Crop Sci....2021...J Am Soc Mass Spectrom....2021...J Chromatogr A.2022, 1685:463640.Indian J. of Experimental Bio....2020...Int J Mol Sci.2019, 20(14):E3538J Appl Biol Chem....2022...Asian J Beauty Cosmetol...2016...
Biomedicines.2020, 8(11):486.Pharmaceuticals (Basel)....2021...Foods.2022, 11(6):882.Antimicrob Agents Chemother....2020...Int J Mol Sci.2019, 21(1):E265Molecules.2019, 24(6):E1155Microchemical Journal2018, 137:168-173
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Our products had been exported to the following research institutions and universities, And still growing.
University of Medicine and Phar... (Romania)Washington State University (USA)Shanghai University of TCM (China)Medizinische Universit?t Wien (Austria)
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DL-Syringaresinol
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
TCI CO.2019, US20190151257A1Int J Mol Sci.2021, 22(21):11836.J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154Front Endocrinol (Lausanne).2020, 11:568436.Nutrients.2019, 12(1)Int J Mol Sci.2020, 21(19):7209.Institute of Food Science & Technology2021, 18 December. Comput Biol Chem.2019, 83:107096J Agric Food Chem.2021, 69(11):3496-3510. Arch Biochem Biophys.2020, 687:108384.
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
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Related Libraries |
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Description: |
(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. |
Targets: |
Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO |
In vitro: |
Biol Pharm Bull. 2006 Jan;29(1):172-3. | Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533] |
METHODS AND RESULTS:
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml. | Int Immunopharmacol. 2008 Jul;8(7):967-73. | (-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907] | METHODS AND RESULTS:
The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
CONCLUSIONS:
These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer. |
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DL-Syringaresinol Description
Source: |
The herbs of Liriodendron tulipifera |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.3901 mL |
11.9503 mL |
23.9006 mL |
47.8011 mL |
59.7514 mL |
5 mM |
0.478 mL |
2.3901 mL |
4.7801 mL |
9.5602 mL |
11.9503 mL |
10 mM |
0.239 mL |
1.195 mL |
2.3901 mL |
4.7801 mL |
5.9751 mL |
50 mM |
0.0478 mL |
0.239 mL |
0.478 mL |
0.956 mL |
1.195 mL |
100 mM |
0.0239 mL |
0.1195 mL |
0.239 mL |
0.478 mL |
0.5975 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Structure Identification: |
Chemische Berichte,1965,98(2):538–539. | Isolierung von DL-Syringaresinol aus Buchenholz[Reference: WebLink] |
METHODS AND RESULTS:
Bei der Perkolation von Buchenholz mit 2-proz. Essigsäure in der Hitze geht das Buchenlignin teilweise in Lösung. Unter den im Extrakt vorkommenden niedermolekularen Phenolen findet sich DL-Syringaresinol. |
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