6-Hydroxystigmasta-4,22-dien-3-one | CAS:36450-01-8

6-Hydroxystigmasta-4,22-dien-3-one

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Description:

6β-Hydroxystigmasta-4,22-dien-3-one exhibits in vitro antibacterial activity; it also shows antioxidant activity, the value of IC50 toward DPPH is 233.4 ± 0.28 uM.

Targets:

Antifection

In vitro:

Fitoterapia. 2003 Feb;74(1-2):159-63.

Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark.[Pubmed: 12628415]

METHODS AND RESULTS:
The extracts as well as piperolactum C, goniopedaline, 6beta-hydroxystigmasta-4,22-dien-3-one(6-Hydroxystigmasta-4,22-dien-3-one ) and a mixture of cis- and trans-4-hydroxymelleins obtained from Uvaria hamiltonii stem bark exhibited mild to moderate in vitro antibacterial activity.
CONCLUSIONS:
The results obtained were compared with a standard antibiotic, kanamycin. In a brine shrimp lethality bioassay the pet-ether, dichloromethane, methanol extracts and a major alkaloid, piperolactum C were found to exhibit mild to moderate cytotoxicity.

Int. J.Pharm.Pharm. Sci.,2014,6(8):350-4.

Radical scavenging activity of triterpene steroids from stem of Polygonum pulchrum Bl[Reference: WebLink]

METHODS AND RESULTS:
Four triterpene steroids; namely, (1) 6Î2-hydroxystigmasta-4,22-dien-3-one(6-Hydroxystigmasta-4,22-dien-3-one ), (2) stigmasterol,(3) stigmasta-4,22-dien-3-one, and (4) ergosterol peroxide, were isolated and identified from stems of P. pulchrum Bl. The antioxidant activities of all compounds were indicated by IC50 value of the compounds. The values of IC50 (Î¼M) of6 Î2-hydroxystigmasta-4,22-dien-3-one, stigmasterol, Stigmasta-4,22-dien-3-on,ergosterol peroxide, and vitamine C (standard) toward DPPH were obtained at 233.4 Â± 0.28; 372.3 Â± 0.33; 144.80 Â± 0.24; 1083.1 Â± 0.38; and 68.9 Â± 0.12, respectively.
CONCLUSIONS:
We found that Stigmasta-4,22-dien-3-onewas the most active compound toward DPPH.

6-Hydroxystigmasta-4,22-dien-3-one Description

Source:	The herbs of Hedyotis diffusa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	6-Hydroxystigmasta-4,22-dien-3-one
Price:
CAS No.:	36450-01-8
Catalog No.:	CFN98495
Molecular Formula:	C₂₉H₄₆O₂
Molecular Weight:	426.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Hedyotis diffusa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antibacterial Compound Library Steroids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3436 mL	11.7178 mL	23.4357 mL	46.8713 mL	58.5892 mL
5 mM	0.4687 mL	2.3436 mL	4.6871 mL	9.3743 mL	11.7178 mL
10 mM	0.2344 mL	1.1718 mL	2.3436 mL	4.6871 mL	5.8589 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

CFN99220	Stigmastane-3,6-diol	112244-29-8	432.7	C₂₉H₅₂O₂
CFN98206	Stigmastane-3,6-dione	22149-69-5	428.7	C₂₉H₄₈O₂
CFN98048	Stigmastane-3,5,6-triol	20835-91-0	448.7	C₂₉H₅₂O₃
CFN97930	Stigmasta-4,22-diene-3beta,6beta-diol	167958-89-6	428.7	C₂₉H₄₈O₂
CFN99234	Stigmast-4-ene-3,6-diol	113626-76-9	430.7	C₂₉H₅₀O₂
CFN98495	6-Hydroxystigmasta-4,22-dien-3-one	36450-01-8	426.7	C₂₉H₄₆O₂
CFN98496	6beta-Hydroxystigmast-4-en-3-one	36450-02-9	428.7	C₂₉H₄₈O₂
CFN98968	Stigmast-4-ene-3,6-dione	23670-94-2	426.7	C₂₉H₄₆O₂
CFN98594	Cyasterone	17086-76-9	520.65	C₂₉H₄₄O₈
CFN90613	Precyasterone	27335-85-9	520.65	C₂₉H₄₄O₈