Anacrotine | CAS:5096-49-1 | Manufacturer ChemFaces

Anacrotine

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Description:

Anacrotine produces much more severe lung damage than most other pyrrolizidine alkaloids.

In vivo:

Chem Biol Interact. 1987;63(1):91-104.

Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats.[Pubmed: 3652286]

The effects of Anacrotine, a pyrrolizidine alkaloid (PA) which has the structure of senecionine with an additional 6-hydroxy group, have been investigated in weanling male rats.
METHODS AND RESULTS:
When Anacrotine was given i.p. (100 mg/kg), pyrrolic metabolites reached a peak level in the liver during the first 0.5 h, then fell rapidly to a lower level which subsequently declined more slowly. Anacrotine caused acute centrilobular necrosis and congestion of the liver when 125 mg/kg or more was given i.p., but oral doses (up to 180 mg/kg) caused relatively little liver necrosis.In contrast, Anacrotine produced much more severe lung damage than most other pyrrolizidine alkaloids. Hearts showed myocardial necrosis of the right ventricular wall. DehydroAnacrotine, the putative reactive pyrrolic metabolite of Anacrotine, given i.v. to rats, caused dose-related chronic lung and heart damage identical to that produced by Anacrotine, but after lower doses (6-27 mg/kg); larger amounts caused acute lung damage.
CONCLUSIONS:
It is suggested that the severe lung damage in animals given Anacrotine is due to dehydroAnacrotine, formed in the liver.

Anacrotine Description

Source:	The herbs of Cassia fistula
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Anacrotine
Price:
CAS No.:	5096-49-1
Catalog No.:	CFN00345
Molecular Formula:	C₁₈H₂₅NO₆
Molecular Weight:	351.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cassia fistula
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Toxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8458 mL	14.2288 mL	28.4576 mL	56.9152 mL	71.144 mL
5 mM	0.5692 mL	2.8458 mL	5.6915 mL	11.383 mL	14.2288 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	5.6915 mL	7.1144 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.1383 mL	1.4229 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.5692 mL	0.7114 mL

CFN00374	Hastacine	20361-77-7	337.41	C₁₈H₂₇NO₅
CFN00388	Nilgirine	21009-05-2	321.37	C₁₇H₂₃NO₅
CFN00389	Crotastriatine	11051-94-8	363.41	C₁₉H₂₅NO₆
CFN00403	Platyphylline	480-78-4	337.41	C₁₈H₂₇NO₅
CFN00404	Hygrophylline	3573-82-8	353.41	C₁₈H₂₇NO₆
CFN00405	Ligularinine	90364-90-2	337.41	C₁₈H₂₇NO₅
CFN00407	Retrorsine	480-54-6	351.40	C₁₈H₂₅NO₆
CFN00409	Usaramine	15503-87-4	351.40	C₁₈H₂₅NO₆
CFN00473	Usaramine N-oxide	117020-54-9	367.4	C₁₈H₂₅NO₇
CFN00412	Rosmarinine	520-65-0	353.41	C₁₈H₂₇NO₆