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    Natural Products
    Apiosylskimmin
    Information
    CAS No. 103529-94-8 Price $656 / 10mg
    Catalog No.CFN90311Purity>=98%
    Molecular Weight456.40Type of CompoundCoumarins
    FormulaC20H24O12Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $413.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • Package
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    Apiosylskimmin

    Apiosylskimmin
    Product Name Apiosylskimmin
    CAS No.: 103529-94-8
    Catalog No.: CFN90311
    Molecular Formula: C20H24O12
    Molecular Weight: 456.40 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Source: The roots of Peucedanum praeruptorum
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $656 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • University of Central Lancashire2017, 20472
  • Nat Prod Sci.2016, 22(2)
  • Horticulture Research2020, 7:111.
  • Front Cell Infect Microbiol.2018, 8:292
  • Asian Journal of Chemistry2014, 26(8):2425
  • Int J Mol Sci.2019, 20(23):E6071
  • Nutrients.2017, 10(1)
  • Applied Biological Chemistry2020, 63:33(2020)
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • J Nat Med.2017, 71(4):745-756
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • Biological Activity
    Description: Apiosylskimmin is a natural product from Angelica gigas.
    In vitro:
    Immunopharmacol Immunotoxicol. 2011 Dec;33(4):663-6.
    Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro.[Pubmed: 21428713]
    The butanol-soluble fraction of the dried root of Angelica gigas exhibited significant protection against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
    METHODS AND RESULTS:
    Using antiplasmodial activity-guided fractionation, five coumarins, marmesinin (1), nodakenin (2), skimmin (3), Apiosylskimmin (4), and magnolioside (5), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 1 and 5 showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 5.3 and 8.2 μM. The compounds showed no significant cytotoxicity (IC(50) > 100 μM) toward the SK-OV-3 cancer cell line.
    CONCLUSIONS:
    This is the first report on the antiplasmodial activity of these coumarin derivatives from the dried root of A. gigas.
    Apiosylskimmin Description
    Source: The roots of Peucedanum praeruptorum
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1911 mL 10.9553 mL 21.9106 mL 43.8212 mL 54.7765 mL
    5 mM 0.4382 mL 2.1911 mL 4.3821 mL 8.7642 mL 10.9553 mL
    10 mM 0.2191 mL 1.0955 mL 2.1911 mL 4.3821 mL 5.4777 mL
    50 mM 0.0438 mL 0.2191 mL 0.4382 mL 0.8764 mL 1.0955 mL
    100 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.4382 mL 0.5478 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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