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    Natural Products
    Cannabisin B
    Cannabisin B
    Information
    CAS No. 144506-17-2 Price $413 / 5mg
    Catalog No.CFN95268Purity>=98%
    Molecular Weight596.6Type of CompoundAlkaloids
    FormulaC34H32N2O8Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $475.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Cannabisin B

    Cannabisin B
    Product Name Cannabisin B
    CAS No.: 144506-17-2
    Catalog No.: CFN95268
    Molecular Formula: C34H32N2O8
    Molecular Weight: 596.6 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Targets: Akt | mTOR
    Source: The herbs of Cannabis sativa L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $413 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Phytomedicine.2015, 22(14):1262-8
  • Int J Mol Sci.2019, 20(9):E2244
  • Biomedicines.2020, 8(11):486.
  • BMC Complement Altern Med.2017, 17(1):393
  • Sci Rep. 2017, 8207(7)
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Biochemistry.2018, 57(40):5886-5896
  • Br J Pharmacol.2020, 10.1111
  • Internoational J of Toxicology2020, 10.1177.
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cell.
    Targets: Akt | mTOR
    In vitro:
    Food Chemistry, 2013,138(2-3):1034-41.
    Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells.[Reference: WebLink]

    METHODS AND RESULTS:
    This study investigates the anticancer properties of Cannabisin B, purified from hempseed hull, in HepG2 human hepatoblastoma cells. The results indicate that Cannabisin B significantly inhibited cell proliferation by inducing autophagic cell death rather than typical apoptosis. Cell viability transiently increased upon the addition of a low concentration of Cannabisin B but decreased upon the addition of high concentrations. Cannabisin B-induced changes in cell viability were completely inhibited by pre-treatment with 3-methyladenine (3-MA), indicating that the induction of autophagy by Cannabisin B caused cell death. Additionally, Cannabisin B induced S phase cell cycle arrest in a dose-dependent manner. Moreover, Cannabisin B was found to inhibit survival signaling by blocking the activation of AKT and down-stream targets of the mammalian target of rapamycin (mTOR).
    CONCLUSIONS:
    These findings suggest that Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease.
    Cannabisin B Description
    Source: The herbs of Cannabis sativa L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6762 mL 8.3808 mL 16.7616 mL 33.5233 mL 41.9041 mL
    5 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
    10 mM 0.1676 mL 0.8381 mL 1.6762 mL 3.3523 mL 4.1904 mL
    50 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3352 mL 0.419 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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