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    Natural Products
    Astin B
    Astin B
    Information
    CAS No. 151201-76-2 Price $318 / 10mg
    Catalog No.CFN95188Purity>95%
    Molecular Weight586.5Type of CompoundAlkaloids
    FormulaC25H33N5O7Cl2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $229.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Astin B

    Astin B
    Product Name Astin B
    CAS No.: 151201-76-2
    Catalog No.: CFN95188
    Molecular Formula: C25H33N5O7Cl2
    Molecular Weight: 586.5 g/mol
    Purity: >95%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The roots of Aster tataricus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Phytomedicine.2015, 22(14):1262-8
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Free Radic Biol Med.2017, 112:191-199
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  • Nat Prod Commun.2018, 10.1177
  • Nutrients.2018, 10(12):E1998
  • Natural Product Communications2020, doi: 10.1177.
  • Front Immunol.2020, 11:598556.
  • Int J Mol Sci.2020, 21(9):3239.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Alkaloids Compound Library
  • Biological Activity
    Description: Astin B has antitumor activity.
    Astin B Description
    Source: The roots of Aster tataricus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.705 mL 8.5251 mL 17.0503 mL 34.1006 mL 42.6257 mL
    5 mM 0.341 mL 1.705 mL 3.4101 mL 6.8201 mL 8.5251 mL
    10 mM 0.1705 mL 0.8525 mL 1.705 mL 3.4101 mL 4.2626 mL
    50 mM 0.0341 mL 0.1705 mL 0.341 mL 0.682 mL 0.8525 mL
    100 mM 0.0171 mL 0.0853 mL 0.1705 mL 0.341 mL 0.4263 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Sep Sci. 2015 Feb;38(4):571-5.
    Simultaneous separation and determination of phenolic acids, pentapeptides, and triterpenoid saponins in the root of Aster tataricus by high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry.[Pubmed: 25491750 ]

    METHODS AND RESULTS:
    We established a qualitative method to analyze the main chemical compositions of the root of Aster tataricus. Most of the peaks were separated on a C(18) column packed with 5.0 μm particles, and 28 compounds were identified, including 11 chlorogenic acids, ten astins/asterinins, and seven astersaponins, four of which were reported for the first time from A. tataricus. Furthermore, we developed a reliable method for the simultaneous quantification of 3-caffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, astin A, Astin B, astin C, astersaponin A, and astersaponin C, and the qualified separations were achieved only on a C18 column packed with 2.7 μm particles.
    CONCLUSIONS:
    The method was used to measure the concentrations of eight components in samples from two major producing areas in China, and the average contents in samples from Bozhou (Anhui) were higher than those in samples from Anguo (Hebei).
    Chem Pharm Bull (Tokyo). 1996 May;44(5):1026-32.
    Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus.[Pubmed: 8689717 ]

    METHODS AND RESULTS:
    Antitumor activities on Sarcoma 180A of a series of cyclic pentapeptides, astins, isolated from the roots of Aster tataricus, were examined.
    CONCLUSIONS:
    The activities on various congeners of the dichlorinated proline residues prepared by chemical conversion and a hepatic microsomal biotransformation in rats suggested that 1,2-cis dichlorinated proline residues of astin A, Astin B and astin C play an important role in the antitumor activity of astins.
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