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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $7.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Horticulturae2020, 6(4),76.Pharmaceutics.2022, 14(3):564.Molecules.2022, 27(2):451.Vietnam Journal of Science...2022...Front Cell Dev Biol.2021, 9:588093.Int. J. of Pha. and Phy. Res....2015...Food Res Int.2019, 123:125-134Free Radic Biol Med.2021, 166:104-115.
Int J Mol Sci.2017, 18(12)Mediators Inflamm. 2016, 2016:6189590J Adv Res.2019, 17:85-94Journal of Third Military Medical...2019...J Pharmacol Sci.2021, 147(2):184-191.Aging (Albany NY)....2021...Food Quality and Safety2018, 2:213-219J Chromatogr B Analyt Technol Bio...2019...
Int J Pharm.2022, 618:121636. Anticancer Res.2014, 34(7):3505-9Indian J. of Experimental Bio....2020...Int J Oncol.2016, 49(4):1497-504Environ Toxicol.2020, doi: 10.1002Front Pharmacol.2018, 9:756Int J Mol Sci.2019, 20(3):E651
Our products had been exported to the following research institutions and universities, And still growing.
Michigan State University (USA)Martin Luther University of Hal... (Germany)Chulalongkorn University (Thailand)Yale University (USA)
University of Leipzig (Germany)University of Otago (New Zealand)Kitasato University (Japan)Celltrion Chemical Research Ins... (Korea)
Research Unit Molecular Epigene... (Germany)Charles Sturt University (Denmark)University of Beira Interior (Portugal)
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Toxicological Research2020, doi: 10.1007.Br J Pharmacol.2016, 173(2):396-410Int J Mol Sci.2021, 22(16):8604.Biochem Systematics and Ecology2017, 11-18Natural Product Communications2020, doi: 10.1177.J Pharmaceut Biomed2020, 182:113110Molecules.2019, 24(11):E2102Appl. Sci.2020, 10(5),1713.Evid-Based Compl Alt2020, 7202519:13Molecules.2017, 22(2)
Related Screening Libraries
|| Benzyl alcohols display marked accelerating effects on the onium salt photoinitiated cationic ring-opening polymerizations of epoxide monomers.Benzyl alcohol could as antimicrobial preservatives, can induce protein aggregation.|
|Pharmaceutical Research, 1997, 14(6):725-729. |
|The effect of benzyl alcohol on recombinant human interferon-gamma.[Pubmed: 9210188]|
|The goal of this study was to investigate the conformational change and aggregation of recombinant human interferon-gamma (rhIFN-gamma) as a result of interaction between Benzyl alcohol and the protein. The effects of buffer concentration, buffer species, ionic strength, rhIFN-gamma and Benzyl alcohol concentrations on the dynamics of the interaction in liquid formulations were also examined.
METHODS AND RESULTS:
The effect of Benzyl alcohol on the secondary and tertiary structure of rhIFN-gamma in succinate and acetate buffers was studied using far-UV and near-UV circular dichroism spectrophotometry, respectively. Dynamic light scattering was employed to detect aggregate formation due to the interaction of Benzyl alcohol with rhIFN-gamma.
The addition of Benzyl alcohol at 0.9% (w/v) in various liquid rhIFN-gamma formulations induced changes in circular dichroism (CD) spectra of the protein in the near-UV region, while the CD spectra in the far-UV region remained unaltered. There were gradual decreases in ellipticity with time throughout the near-UV CD spectra. The decreases in near-UV ellipticity induced by Benzyl alcohol were accompanied by the formation of high molecular weight aggregates as measured by dynamic light scattering. Loss in near-UV ellipticity was accelerated at lower protein concentration and by increasing buffer or Benzyl alcohol concentration. It was also faster in succinate than in acetate buffer. Formulation ionic strength did not affect the CD spectral changes in both the near- and far-UV regions.
Interaction between Benzyl alcohol and rhIFN-gamma is formulation dependent. Protein concentration, buffer species, buffer concentration, and preservative concentration play a significant role in determining the extent of the interaction and consequently the stability of the product.
|Journal of Pharmaceutical ences, 2010, 94(2):382-396. |
|Effects of Benzyl Alcohol on Aggregation of Recombinant Human Interleukin-1-Receptor Antagonist in Reconstituted Lyophilized Formulations.[Reference: WebLink]|
|A major limitation in the successful development of multidose protein formulations is protein aggregation induced by antimicrobial preservatives such as Benzyl alcohol, which are included to maintain product sterility.
METHODS AND RESULTS:
Studies were conducted to evaluate the strategy of developing lyophilized formulations of a therapeutic protein, recombinant human interlukin-1 receptor antagonist (rhIL-1ra), to be reconstituted with a bacteriostatic amount (0.9% w/v) of Benzyl alcohol in water. The strategy was based on the following hypotheses. The first was that Benzyl alcohol would foster aggregation during reconstitution of the lyophilized sample. The second hypothesis was that the extent of Benzyl alcohol-induced protein aggregation would correlate directly with the degree of structural perturbation of rhIL-1ra in the dried solid after lyophilization. Differential structural retention of rhIL-1ra in the dried solid was obtained by using a combination of formulation variables important for lyophilization and included: protein concentration, type of stabilizer, and presence or absence of NaCl. Infrared spectroscopic analysis of the lyophilized samples indicated that high initial solution protein concentration and the stabilizer sucrose minimized structural perturbation of rhIL-1ra during lyophilization. In contrast, NaCl was destabilizing. Reconstitution of the dried solid with 0.9% (w/v) Benzyl alcohol caused a greater degree of protein aggregation than reconstitution with water, confirming our first hypothesis. In support of our second hypothesis, the extent of aggregation induced by Benzyl alcohol during reconstitution was strongly modulated by the degree of retention of native rhIL-1ra secondary structure during lyophilization. During storage of the reconstituted lyophilized samples at room temperature, Benzyl alcohol did not accelerate aggregation of rhIL-1ra.
This study demonstrated that for development a multidose lyophilized protein formulation involving reconstitution with a solution of Benzyl alcohol, protein structural perturbations during freeze-drying should be minimized with a stabilizing excipient and appropriate choice of protein concentration and tonicity modifier. Furthermore, postreconstitution storage at reduced temperature (e.g., room temperature or 4°C) could minimize the risk of preservative-induced protein aggregation.
Benzyl alcohol Description
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Journal of Polymer ence Part A Polymer Chemistry, 2010,40(14) 2298-2309. |
|Benzyl alcohols as accelerators in the photoinitiated cationic polymerization of epoxide monomers.[Reference: WebLink]|
METHODS AND RESULTS:
Benzyl alcohols display marked accelerating effects on the onium salt photoinitiated cationic ring-opening polymerizations of epoxide monomers. The participation of radicals in these polymerizations was demonstrated, and a pronounced accelerating effect on the polymerization rate was observed depending on the character of the substituent on the benzene ring of the alcohol. 4-MethoxyBenzyl alcohol was considerably more reactive than Benzyl alcohol, whereas the analogous chloro- and nitrosubstituted compounds were less reactive. Piperonyl alcohol was even more reactive as an accelerator in these polymerizations. The UV irradiation of an onium salt cationic photoinitiator generates Brönsted acids that initiate the cationic ring-opening polymerization of the epoxide monomer. In the presence of Benzyl alcohol, the usual polymerization mechanism is diverted and proceeds by a more-rapid activated monomer mechanism.
As a result, benzyl ether groups are incorporated at the termini of the polymer chains. Aryl radicals that are also generated by photolysis of the onium salt abstract labile benzyl ether protons, and the benzyl ether radicals that are produced are subsequently oxidized by the onium salt to afford the corresponding benzyl carbocations. This takes place by a chain process. The polymer bound benzyl cations serve as additional sites for the initiation of cationic polymerization.
It is proposed that these two mechanisms acting in synergy with one another account for the observed accelerating effect on the polymerization rate.