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    Natural Products
    Benzyl alcohol
    Benzyl alcohol
    Information
    CAS No. 100-51-6 Price $30 / 20mg
    Catalog No.CFN70036Purity>=98%
    Molecular Weight108.1Type of CompoundPhenols
    FormulaC7H8OPhysical DescriptionOil
    Download COA    MSDSSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
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    Benzyl alcohol

    Benzyl alcohol
    Product Name Benzyl alcohol
    CAS No.: 100-51-6
    Catalog No.: CFN70036
    Molecular Formula: C7H8O
    Molecular Weight: 108.1 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Oil
    Targets: Antifection
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Phenols Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Benzyl alcohols display marked accelerating effects on the onium salt photoinitiated cationic ring-opening polymerizations of epoxide monomers.Benzyl alcohol could as antimicrobial preservatives, can induce protein aggregation.
    Targets: Antifection
    In vitro:
    Pharmaceutical Research, 1997, 14(6):725-729.
    The effect of benzyl alcohol on recombinant human interferon-gamma.[Pubmed: 9210188]
    The goal of this study was to investigate the conformational change and aggregation of recombinant human interferon-gamma (rhIFN-gamma) as a result of interaction between Benzyl alcohol and the protein. The effects of buffer concentration, buffer species, ionic strength, rhIFN-gamma and Benzyl alcohol concentrations on the dynamics of the interaction in liquid formulations were also examined.
    METHODS AND RESULTS:
    The effect of Benzyl alcohol on the secondary and tertiary structure of rhIFN-gamma in succinate and acetate buffers was studied using far-UV and near-UV circular dichroism spectrophotometry, respectively. Dynamic light scattering was employed to detect aggregate formation due to the interaction of Benzyl alcohol with rhIFN-gamma. The addition of Benzyl alcohol at 0.9% (w/v) in various liquid rhIFN-gamma formulations induced changes in circular dichroism (CD) spectra of the protein in the near-UV region, while the CD spectra in the far-UV region remained unaltered. There were gradual decreases in ellipticity with time throughout the near-UV CD spectra. The decreases in near-UV ellipticity induced by Benzyl alcohol were accompanied by the formation of high molecular weight aggregates as measured by dynamic light scattering. Loss in near-UV ellipticity was accelerated at lower protein concentration and by increasing buffer or Benzyl alcohol concentration. It was also faster in succinate than in acetate buffer. Formulation ionic strength did not affect the CD spectral changes in both the near- and far-UV regions.
    CONCLUSIONS:
    Interaction between Benzyl alcohol and rhIFN-gamma is formulation dependent. Protein concentration, buffer species, buffer concentration, and preservative concentration play a significant role in determining the extent of the interaction and consequently the stability of the product.
    Journal of Pharmaceutical ences, 2010, 94(2):382-396.
    Effects of Benzyl Alcohol on Aggregation of Recombinant Human Interleukin-1-Receptor Antagonist in Reconstituted Lyophilized Formulations.[Reference: WebLink]
    A major limitation in the successful development of multidose protein formulations is protein aggregation induced by antimicrobial preservatives such as Benzyl alcohol, which are included to maintain product sterility.
    METHODS AND RESULTS:
    Studies were conducted to evaluate the strategy of developing lyophilized formulations of a therapeutic protein, recombinant human interlukin-1 receptor antagonist (rhIL-1ra), to be reconstituted with a bacteriostatic amount (0.9% w/v) of Benzyl alcohol in water. The strategy was based on the following hypotheses. The first was that Benzyl alcohol would foster aggregation during reconstitution of the lyophilized sample. The second hypothesis was that the extent of Benzyl alcohol-induced protein aggregation would correlate directly with the degree of structural perturbation of rhIL-1ra in the dried solid after lyophilization. Differential structural retention of rhIL-1ra in the dried solid was obtained by using a combination of formulation variables important for lyophilization and included: protein concentration, type of stabilizer, and presence or absence of NaCl. Infrared spectroscopic analysis of the lyophilized samples indicated that high initial solution protein concentration and the stabilizer sucrose minimized structural perturbation of rhIL-1ra during lyophilization. In contrast, NaCl was destabilizing. Reconstitution of the dried solid with 0.9% (w/v) Benzyl alcohol caused a greater degree of protein aggregation than reconstitution with water, confirming our first hypothesis. In support of our second hypothesis, the extent of aggregation induced by Benzyl alcohol during reconstitution was strongly modulated by the degree of retention of native rhIL-1ra secondary structure during lyophilization. During storage of the reconstituted lyophilized samples at room temperature, Benzyl alcohol did not accelerate aggregation of rhIL-1ra.
    CONCLUSIONS:
    This study demonstrated that for development a multidose lyophilized protein formulation involving reconstitution with a solution of Benzyl alcohol, protein structural perturbations during freeze-drying should be minimized with a stabilizing excipient and appropriate choice of protein concentration and tonicity modifier. Furthermore, postreconstitution storage at reduced temperature (e.g., room temperature or 4°C) could minimize the risk of preservative-induced protein aggregation.
    Benzyl alcohol Description
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 9.2507 mL 46.2535 mL 92.5069 mL 185.0139 mL 231.2673 mL
    5 mM 1.8501 mL 9.2507 mL 18.5014 mL 37.0028 mL 46.2535 mL
    10 mM 0.9251 mL 4.6253 mL 9.2507 mL 18.5014 mL 23.1267 mL
    50 mM 0.185 mL 0.9251 mL 1.8501 mL 3.7003 mL 4.6253 mL
    100 mM 0.0925 mL 0.4625 mL 0.9251 mL 1.8501 mL 2.3127 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Journal of Polymer ence Part A Polymer Chemistry, 2010,40(14) 2298-2309.
    Benzyl alcohols as accelerators in the photoinitiated cationic polymerization of epoxide monomers.[Reference: WebLink]

    METHODS AND RESULTS:
    Benzyl alcohols display marked accelerating effects on the onium salt photoinitiated cationic ring-opening polymerizations of epoxide monomers. The participation of radicals in these polymerizations was demonstrated, and a pronounced accelerating effect on the polymerization rate was observed depending on the character of the substituent on the benzene ring of the alcohol. 4-MethoxyBenzyl alcohol was considerably more reactive than Benzyl alcohol, whereas the analogous chloro- and nitrosubstituted compounds were less reactive. Piperonyl alcohol was even more reactive as an accelerator in these polymerizations. The UV irradiation of an onium salt cationic photoinitiator generates Brönsted acids that initiate the cationic ring-opening polymerization of the epoxide monomer. In the presence of Benzyl alcohol, the usual polymerization mechanism is diverted and proceeds by a more-rapid activated monomer mechanism. As a result, benzyl ether groups are incorporated at the termini of the polymer chains. Aryl radicals that are also generated by photolysis of the onium salt abstract labile benzyl ether protons, and the benzyl ether radicals that are produced are subsequently oxidized by the onium salt to afford the corresponding benzyl carbocations. This takes place by a chain process. The polymer bound benzyl cations serve as additional sites for the initiation of cationic polymerization.
    CONCLUSIONS:
    It is proposed that these two mechanisms acting in synergy with one another account for the observed accelerating effect on the polymerization rate.
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