ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $42.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Separation Science & Technology...2016...J Chromatogr B Analyt Technol Bio...2017...Food Chem.2017, 221:1135-1144Cell Physiol Biochem....2017...Evid Based Complement Alternat Me...2018...Life Sci.2018, 209:498-506Journal of Third Military Medical...2018...Pathogens.2018, 7(3):E62
Saf Health Work.2019, 10(2):196-204Front Pharmacol.2019, 10:1025J Chromatogr B Analyt Technol Bio...2019...J Ethnopharmacol.2019, 228:132-141Molecules.2019, 24(11):E2102J Ethnopharmacol.2020, 249:112396Plant Growth Regulation...2020...Nutrients.2020, 12(12):3607.
Nutr Res Pract.2020, 14(5):478-489.BMB Rep.2020, 53(4):218-222.J Nat Med.2020, 74(3):550-560.SCOPUS.2020, 836-847.Natural Product Communications...2020...Molecules2021, 26(1),230Journal of Apicultural Research...2021...
Our products had been exported to the following research institutions and universities, And still growing.
St. Jude Children Research Hosp... (USA)University of Vigo (Spain)University of Toulouse (France)Max-Planck-Insitut (Germany)
Charles Sturt University (Denmark)Uniwersytet Gdański (Poland)University of Helsinki (Finland)Universit?t Basel (Switzerland)
VIB Department of Plant Systems... (Belgium)MTT Agrifood Research Finland (Finland)Copenhagen University (Denmark)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Sci Rep. 2017, 17332(7)Food Chem.2016, 191:81-90Phytomedicine.2016, 23(4):331-9Molecules.2018, 23(2)Sci Rep.2019, 9(1):6429Food Sci Biotechnol.2016, 25(5):1437-1442Pharmacognosy Journal.2020, 12(2), p232-235.FASEB J.2019, 33(8):9685-9694PLoS One.2020, 15(2):e0220084.Sci Rep.2016, 6:25094
Related Screening Libraries
|| Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(50) values.|
||The herbs of Forsythia suspensa.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jan;85(1):120-6. |
|Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking.[Pubmed: 22000638]|
METHODS AND RESULTS:
In this paper, the interaction of human serum albumin (HSA) with Phillygenin was investigated by fluorescence, circular dichroism (CD), UV-vis spectroscopic and molecular docking methods under physiological conditions. The Stern-Volmer analysis indicated that the fluorescence quenching of HSA by Phillygenin resulted from static mechanism, and the binding constants were 1.71×10(5), 1.61×10(5) and 1.47×10(4) at 300, 305 and 310K, respectively. The results of UV-vis spectra show that the secondary structure of the protein has been changed in the presence of Phillygenin. The CD spectra showed that HSA conformation was altered by Phillygenin with a major reduction of α-helix and an increase in β-sheet and random coil structures, indicating a partial protein unfolding. The distance between donor (HSA) and acceptor (Phillygenin) was calculated to be 3.52nm and the results of synchronous fluorescence spectra showed that binding of Phillygenin to HSA can induce conformational changes in HSA. Molecular docking experiments found that Phillygenin binds with HSA at IIIA domain of hydrophobic pocket with hydrogen bond interactions. The ionic bonds were formed with the O (4), O (5) and O (6) of Phillygenin with nitrogen of ASN109, ARG186 and LEU115, respectively. The hydrogen bonds are formed between O (2) of Phillygenin and SER419. In the presence of copper (II), iron (III) and alcohol, the apparent association constant K(A) and the number of binding sites of Phillygenin on HSA were both decreased in the range of 88.84-91.97% and 16.09-18.85%, respectively.
In view of the evidence presented, it is expected to enrich our knowledge of the interaction dynamics of Phillygenin to the important plasma protein HSA, and it is also expected to provide important information of designs of new inspired drugs.