(-)-Bicuculline methochloride | CAS:53552-05-9

(-)-Bicuculline methochloride

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Description:

(-)-Bicuculline methochloride is a GABAA-receptor antagonist. Exposure to 100 microM (-)-Bicuculline methochloride for 48 hr can result in prominent CA1 cell death.

Targets:

GABA Receptor

In vitro:

Int J Neurosci. 2010 Dec;120(12):752-9.

Effect of low Mg2+ and bicuculline on cell survival in hippocampal slice cultures.[Pubmed: 20942591]

A reliable model system of epileptiform insult would facilitate investigation into the underlying biological mechanisms.
METHODS AND RESULTS:
Epileptiform insult was induced in hippocampal slice cultures by lowering extracellular Mg(2+), (+)-bicuculline, or (-)-Bicuculline methochloride, a stable salt form of bicuculline (both forms block GABA(A) receptors). Cell death was assessed by propidium iodide uptake. Low Mg(2+) or (+)-bicuculline did not produce cell death regardless of dose or incubation period. Exposure to 100 microM (-)-Bicuculline methochloride for 48 hr resulted in prominent CA1 cell death.
CONCLUSIONS:
These findings demonstrate that not all pro-epileptic drugs/ion changes used routinely for electrophysiological recording of seizure activity lead to cell death in hippocampal slice cultures and that treatment with bicuculline methochloride can be used as a reliable model for epileptiform insult.

(-)-Bicuculline methochloride Description

Source:	The tubers of Corydalis ambigua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(-)-Bicuculline methochloride
Price:
CAS No.:	53552-05-9
Catalog No.:	CFN92860
Molecular Formula:	C₂₁H₂₀NO₆.Cl
Molecular Weight:	417.8 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The tubers of Corydalis ambigua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	GABA(A) receptor blockers Compound Library Alkaloids Compound Library GABA Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3935 mL	11.9674 mL	23.9349 mL	47.8698 mL	59.8372 mL
5 mM	0.4787 mL	2.3935 mL	4.787 mL	9.574 mL	11.9674 mL
10 mM	0.2393 mL	1.1967 mL	2.3935 mL	4.787 mL	5.9837 mL
50 mM	0.0479 mL	0.2393 mL	0.4787 mL	0.9574 mL	1.1967 mL
100 mM	0.0239 mL	0.1197 mL	0.2393 mL	0.4787 mL	0.5984 mL

CFN99514	Colchicine	64-86-8	399.44	C₂₂H₂₅NO₆
CFN91817	N-Methylcolchicine	7336-40-5	413.5	C₂₃H₂₇NO₆
CFN91554	Thiocolchicine	2730-71-4	415.5	C₂₂H₂₅NO₅S
CFN91553	Thiocolchicoside	602-41-5	563.6	C₂₇H₃₃NO₁₀S
CFN96340	(-)-Corlumine	79082-64-7	383.4	C₂₁H₂₁NO₆
CFN99748	(+)-Bicuculline	485-49-4	367.36	C₂₀H₁₇NO₆
CFN92860	(-)-Bicuculline methochloride	53552-05-9	417.8	C₂₁H₂₀NO₆.Cl
CFN92333	Hypecorinine	41787-57-9	367.4	C₂₀H₁₇NO₆
CFN92448	Isohyperectine	170384-75-5	447.5	C₂₄H₂₁N₃O₆
CFN92449	Hyperectine	94656-46-9	447.5	C₂₄H₂₁N₃O₆