Casegravol | CAS:74474-76-3 | Manufacturer ChemFaces

Casegravol

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Description:

Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.

In vitro:

Biol Pharm Bull. 2004 Aug;27(8):1312-6.

Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.[Pubmed: 15305045]

METHODS AND RESULTS:
The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, Casegravol, cis-Casegravol, and edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora.
CONCLUSIONS:
The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.

Casegravol Description

Source:	The herbs of Murraya paniculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Casegravol
Price:
CAS No.:	74474-76-3
Catalog No.:	CFN97693
Molecular Formula:	C₁₅H₁₆O₅
Molecular Weight:	276.29 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Murraya paniculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6194 mL	18.0969 mL	36.1939 mL	72.3877 mL	90.4846 mL
5 mM	0.7239 mL	3.6194 mL	7.2388 mL	14.4775 mL	18.0969 mL
10 mM	0.3619 mL	1.8097 mL	3.6194 mL	7.2388 mL	9.0485 mL
50 mM	0.0724 mL	0.3619 mL	0.7239 mL	1.4478 mL	1.8097 mL
100 mM	0.0362 mL	0.181 mL	0.3619 mL	0.7239 mL	0.9048 mL

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CFN97531	Sibiricin	95188-34-4	290.3	C₁₆H₁₈O₅
CFN97454	Isomexoticin	88585-86-8	308.3	C₁₆H₂₀O₆
CFN99097	Murraol	109741-38-0	260.3	C₁₅H₁₆O₄
CFN97693	Casegravol	74474-76-3	276.29	C₁₅H₁₆O₅
CFN91058	Osthenol	484-14-0	230.3	C₁₄H₁₄O₃
CFN98765	Osthol	484-12-8	244.3	C₁₅H₁₆O₃
CFN98249	Meranzin	23971-42-8	260.3	C₁₅H₁₆O₄
CFN90848	Osthol hydrate	69219-24-5	262.3	C₁₅H₁₈O₄
CFN89183	3'-O-Methylmurraol	1891097-17-8	274.31	C₁₆H₁₈O₄