Clemastanin B | CAS:112747-98-5 | Manufacturer ChemFaces

Clemastanin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $235.4 / In-stock
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Description:

Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment.

Targets:

Influenza virus | Immunology & Inflammation related

In vitro:

J Tradit Chin Med. 2016 Jun;36(3):369-76.

Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis).[Pubmed: 27468553]

To study the antiviral activities of Clemastanin B (CB), epigoitrin, phenylpropanoids portion (PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions (PEP ALK OA) from Banlangen (Radix Isatidis).
METHODS AND RESULTS:
The experiment consisted of four parts: therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect (CPE) and 3-(4,5-Dimethylthiazol-2-yI)-2,5-diphenyltetrazolium (MTT) were used to assess antiviral activity. CB, epigoitrin, PEP and PEP ALK OA fractions from Banlangen (Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions (P < 0.01). Pretreated with either pure compounds or chemical fractions of Banlangen (Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells (P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.
CONCLUSIONS:
CB, epigoitrin, PEP and PEP ALK OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP ALK OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.

In vivo:

J Ethnopharmacol. 2014 Nov 18;157:55-61.

In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.[Pubmed: 25256688]

Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, Clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
METHODS AND RESULTS:
High performance liquid chromatography (HPLC) technique was adopted to determine the bioaccessibility of six bioactive compounds in RIE. Antioxidant activities of RIE in different digestive stages were determined by 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl radical scavenging abilities. Anti-inflammatory activity was assayed by the inhibitions of inflammatory cytokines such as nitrous oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor α(TNF-α) producted by lipopolysaccharide (LPS) stimulated RAW264.7 cells. The bioaccessibility of uridine, epigoitrin, adenosine, Clemastanin B, indigoticoside A and isolariciresinol were 15.38%, 18.28%, 24.01%, 6.50%, 8.65% and 17.78%, respectively. Also, the digestion products still possessed certain antioxidant activities. The antioxidant activity was highly correlated with lignans (Clemastanin B, indigoticoside A and isolariciresino). The anti-inflammation activity of the three samples decreased in the order: IN sample (the solution that had diffused into the dialysis tubing)>Nondigested sample (RIE solution)>Gastric sample (post-gastric digestion)>OUT sample (material that remained in the gastro-intestinal tract).
CONCLUSIONS:
Results obtained in this research reveal the amount of bioactive compounds from RIE that could be available for absorption in vivo. The antioxidant activity decreased significantly but the anti-inflammatory activity was enhanced in serum-available fraction after gastro-intestinal digestion in vitro. This study could provide a scientific basis for a deeper pharmacological activity study of Radix Isatidis and a simple method for pharmacodynamic material basis research.

Clemastanin B Description

Source:	The roots of Stellera chamaejasme L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

CAS No.	112747-98-5	Price	$298 / 10mg
Catalog No.	CFN95064	Purity	>=98%
Molecular Weight	684.7	Type of Compound	Lignans
Formula	C₃₂H₄₄O₁₆	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Clemastanin B
CAS No.:	112747-98-5
Catalog No.:	CFN95064
Molecular Formula:	C₃₂H₄₄O₁₆
Molecular Weight:	684.7 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Targets:	Influenza virus \| Immunology & Inflammation related
Source:	The roots of Stellera chamaejasme L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$298 / 10mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library Influenza virus Inhibitor Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4605 mL	7.3025 mL	14.6049 mL	29.2099 mL	36.5123 mL
5 mM	0.2921 mL	1.4605 mL	2.921 mL	5.842 mL	7.3025 mL
10 mM	0.146 mL	0.7302 mL	1.4605 mL	2.921 mL	3.6512 mL
50 mM	0.0292 mL	0.146 mL	0.2921 mL	0.5842 mL	0.7302 mL
100 mM	0.0146 mL	0.073 mL	0.146 mL	0.2921 mL	0.3651 mL

CFN95390	Tortoside B (Manglieside E)	190655-17-5	582.6	C₂₈H₃₈O₁₃
CFN91784	Tortoside A	190655-16-4	580.58	C₂₈H₃₆O₁₃
CFN96282	Sanshodiol	54854-91-0	358.4	C₂₀H₂₂O₆
CFN92501	(-)-Lariciresinol	83327-19-9	360.4	C₂₀H₂₄O₆
CFN97744	Taxiresinol	40951-69-7	346.38	C₁₉H₂₂O₆
CFN98324	Lariciresinol	27003-73-2	360.4	C₂₀H₂₄O₆
CFN97679	Lariciresinol acetate	79114-77-5	402.44	C₂₂H₂₆O₇
CFN97023	9-O-Feruloyllariciresinol	60337-67-9	536.6	C₃₀H₃₂O₉
CFN95400	Lariciresinol 4'-O-glucoside	107110-16-7	522.6	C₂₆H₃₄O₁₁
CFN95389	Lariciresinol 4-O-glucoside	143663-00-7	522.6	C₂₆H₃₄O₁₁