Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Cedrol
    Cedrol
    Information
    CAS No. 77-53-2 Price $30 / 20mg
    Catalog No.CFN70197Purity>=98%
    Molecular Weight222.3Type of CompoundSesquiterpenoids
    FormulaC15H26OPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $8.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Imperial College London (United Kingdom)
  • Tohoku University (Japan)
  • Deutsches Krebsforschungszentrum (Germany)
  • Kyoto University (Japan)
  • National Hellenic Research Foun... (Greece)
  • Sant Gadge Baba Amravati Univer... (India)
  • Universidade Federal de Pernamb... (Brazil)
  • University of Madras (India)
  • University of Eastern Finland (Finland)
  • Lodz University of Technology (Poland)
  • University of Illinois at Chicago (USA)
  • More...
  • Package
    Featured Products
    Chamaejasmenin C

    Catalog No: CFN92061
    CAS No: 89595-70-0
    Price: $498/5mg
    Gomisin N

    Catalog No: CFN90125
    CAS No: 69176-52-9
    Price: $268/20mg
    Pd-C-II

    Catalog No: CFN95003
    CAS No: N/A
    Price: $358/5mg
    Ginsenoside Rg5

    Catalog No: CFN92643
    CAS No: 186763-78-0
    Price: $168/10mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $/mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg

    Cedrol

    Cedrol
    Product Name Cedrol
    CAS No.: 77-53-2
    Catalog No.: CFN70197
    Molecular Formula: C15H26O
    Molecular Weight: 222.3 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Powder
    Targets: Antifection | Autophagy | PI3K | Akt | ROS | CYP2B6 | CYP3A4
    Source: The heartwoods from Juniperus virginiana L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Nutr Res Pract2019, 13:e45
  • Journal of Functional Foods2021, 84:104581
  • Int J Mol Sci.2019, 20(8):E1855
  • Int J Mol Sci.2020, 21(8):2790.
  • Korean J Environ Agric.2018, 37(4):260-267
  • Planta Med.2018, 84(15):1101-1109
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Molecules 2021, 26(4),1092.
  • Biomed Pharmacother.2019, 116:108987
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Sesquiterpenoids Compound Library
  • ROS Inhibitor Library
  • PI3K Inhibitor Library
  • Autophagy Inhibitor Library
  • Antifection Inhibitor Library
  • Akt Inhibitor Library
  • Biological Activity
    Description: Cedrol shows antifungal activity against the fungus Botrytis cinerea , it has the potential of becoming a new hair growth promoter. Cedrol has sedative effects, it induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS. Cedrol is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with the inhibition constant (Ki) value of 0.9, μM, it also markedly inhibited CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM.
    Targets: Antifection | Autophagy | PI3K | Akt | ROS | CYP2B6 | CYP3A4
    In vitro:
    Journal of Molecular Catalysis B Enzymatic, 2001, 11(4-6):329-334.
    Biotransformation of the fungistatic sesquiterpenoids patchoulol, ginsenol, cedrol and globulol by Botrytis cinerea.[Reference: WebLink]

    METHODS AND RESULTS:
    The antifungal activity of natural sesquiterpenoids patchoulol, ginsenol, Cedrol and globulol against the fungus Botrytis cinerea has been determined. The diminishing of the effect after 3–6 days suggests that a mechanism of detoxification is present.
    CONCLUSIONS:
    Biotransformation of these fungistatic compounds has been investigated as a method of studying this mechanism.
    International Journal of Molecular Medicine, 2016,38(1): 291-299.
    Cedrol induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS.[Reference: WebLink]
    The objective of the present study was to determine the anticancer effects of Cedrol in A549 human non-small cell lung cancer cells by examining the effects of Cedrol on apoptosis induction, the phosphatidylinositol 3'-kinase (PI3K)/Akt signaling pathway, autophagy, reactive oxygen species (ROS) generation and mitochondrial transmembrane potential (MTP).
    METHODS AND RESULTS:
    The anticancer effects of Cedrol were examined using A549 human lung carcinoma cells as an in vitro model. Cell viability was determined using MTT and lactate dehydrogenase (LDH) assays, and an inverted phase contrast microscope was used to examine the morphological changes in these cells. Cedroltriggered autophagy was confirmed by transmission electron microscopy (TEM) analysis of the cells, as well as by western blot analysis of microtubule-associated protein light-chain 3 (LC3)B expression. Intracellular ROS generation was measured by flow cytometry using 5-(6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate (CM-DCFH2-DA) staining and MTP was measured using flow cytometry. The results demonstrated that Cedrol reduced cell viability and induced cell apoptosis in a dose-dependent manner. Mechanistic evaluations indicated that Cedrol induced apoptosis by reducing the MTP and by decreasing the levels of phosphorylated (p-)PI3K and p-Akt. Cedrol induced autophagy, which was confirmed by TEM analysis, by increasing intracellular ROS formation in a concentration-dependent manner, which was almost completely reversed by N-acetyl-L-cysteine (NAC) and tocopherol.
    CONCLUSIONS:
    Taken together, these findings reveal that Cedrol inhibits cell proliferation and induces apoptosis in A549 cells through mitochondrial and PI3K/Akt signaling pathways. Our findings also reveal that Cedrol induced pro-death autophagy by increasing intracellular ROS production.
    Cedrol Description
    Source: The heartwoods from Juniperus virginiana L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    3-Oxo-alpha-ilexanolic acid

    Catalog No: CFN95496
    CAS No: N/A
    Price: $413/5mg
    Cajanine

    Catalog No: CFN95448
    CAS No: 87402-84-4
    Price: $318/5mg
    Hamaudol

    Catalog No: CFN95115
    CAS No: 735-46-6
    Price: $318/10mg
    Poricoic acid B

    Catalog No: CFN95050
    CAS No: 137551-39-4
    Price: $318/20mg
    Platycodin J

    Catalog No: CFN95395
    CAS No: 1325614-80-9
    Price: $318/5mg
    Epischisandrone

    Catalog No: CFN95212
    CAS No: 98619-26-2
    Price: $413/5mg
    Caffeoylcalleryanin

    Catalog No: CFN95532
    CAS No: 20300-49-6
    Price: $318/10mg
    New compound 8

    Catalog No: CFN95341
    CAS No: N/A
    Price: $318/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4984 mL 22.4921 mL 44.9843 mL 89.9685 mL 112.4606 mL
    5 mM 0.8997 mL 4.4984 mL 8.9969 mL 17.9937 mL 22.4921 mL
    10 mM 0.4498 mL 2.2492 mL 4.4984 mL 8.9969 mL 11.2461 mL
    50 mM 0.09 mL 0.4498 mL 0.8997 mL 1.7994 mL 2.2492 mL
    100 mM 0.045 mL 0.2249 mL 0.4498 mL 0.8997 mL 1.1246 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    J Toxicol Environ Health A, 2014, 77(22-24):1522-1532.
    Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes.[Reference: WebLink]
    Cedrol, β-cedrene, and thujopsene are bioactive sesquiterpenes found in cedar essential oil and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative, insecticidal, and antifungal activities. These compounds are used globally in traditional medicine and cosmetics.
    METHODS AND RESULTS:
    The aim of this study was to investigate the inhibitory effects of Cedrol, β-cedrene, and thujopsene on the activities of eight major human cytochrome P-450 (CYP) enzymes using human liver microsomes to assess potential β-cedrene-, Cedrol-, and thujopsene-drug interactions. Cedrol, β-cedrene, and thujopsene were found to be potent competitive inhibitors of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) values of 0.9, 1.6, and 0.8 μM, respectively, comparable with that of a selective CYP2B6 inhibitor, thioTEPA (Ki, 2.9 μM). Cedrol also markedly inhibited CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM, whereas β-cedrene and thujopsene moderately blocked CYP3A4. Cedrol, β-cedrene, and thujopsene at 100 μM negligibly inhibited CYP1A2, CYP2A6, and CYP2D6 activities. Only thujopsene was found to be a mechanism-based inhibitor of CYP2C8, CYP2C9, and CYP2C19. Cedrol and thujopsene weakly inhibited CYP2C8, CYP2C9, and CYP2C19 activities, but β-cedrene did not.
    CONCLUSIONS:
    These in vitro results indicate that Cedrol, β-cedrene, and thujopsene need to be examined for potential pharmacokinetic drug interactions in vivo due to their potent inhibition of CYP2B6 and CYP3A4.
    Animal Research:
    Planta Medica, 2003, 69(7):637--641.
    The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation.[Reference: WebLink]
    It has been reported that cedarwood oil has sedative effects when inhaled. In this study, we evaluated sedative effects of inhaled Cedrol, which is a major component of cedarwood oil.
    METHODS AND RESULTS:
    Accumulative spontaneous motor activity was significantly decreased in the Cedrol-exposed Wistar rats. Similar results were confirmed in caffeine-treated Wistar rats, spontaneously hypertensive rats (SHR), and ddY mice. In addition, exposure to Cedrol prolonged pentobarbital-induced sleeping time in Wistar rats. To investigate whether Cedrol, which has a very faint aroma, affects the olfactory system, the nasal cavities of Wistar rats were treated with zinc sulfate to reduce olfactory function. Two days later, the pentobarbital-induced sleep time was measured as described above. Compared to intact rats, the sleep prolongation effect was decreased in a lavender-roman chamomile mixed oil exposure positive control group, indicating that olfactory function was impaired. In contrast, prolongation of the sleeping time did not change in the Cedrol exposure group.
    CONCLUSIONS:
    The above findings indicate that Cedrol inhalation had marked sedative effects regardless of the animal species or the functional state of the autonomic nerves, suggesting that the mechanism of action is via a pathway other than the olfactory system.
    Environmental Entomology,2014,43(3):762–766.
    Bioactivity of Cedarwood Oil and Cedrol Against Arthropod Pests.[Reference: WebLink]

    METHODS AND RESULTS:
    Heartwood samples from Juniperus virginiana L. were extracted with liquid carbon dioxide, and the bioactivity of carbon dioxide-derived cedarwood oil (CWO) toward several species of ants and Cedrol toward ticks was determined. Repellency was tested for ants, and toxicity was tested for ticks. Ants in an outdoor bioassay were significantly repelled by the presence of CWO on a pole leading to a sugar-water solution. Similarly, CWO was a significant repellent barrier to red imported fire ants and prevented them from finding a typical food source. Black-legged tick nymphs exhibited dosage-dependent mortality when exposed to Cedrol and at the highest dosage (i.e., 6.3 mg/ml) tested, the Cedrol killed 100% of the ticks.
    CONCLUSIONS:
    These repellency and toxicity results together demonstrate a clear potential for the use of CWO as a pest control agent.
    Biomedicine & Pharmacotherapy, 2016, 83:641-647.
    Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis.[Reference: WebLink]
    Platycladus orientalis (L.) Franco is traditionally known to potentiate hair growth promotion. However, there has been no report on its main active ingredient responsible for the hair growth activity.
    METHODS AND RESULTS:
    In the current work, Cedrol as a major constituent from P. orientalis was evaluated for its potential on hair growth in vivo. Different concentrations of Cedrol (10, 20 and 30mg/mL) were applied topically over the shaved skin of C57BL/6 mice and monitored for 21days. Results indicated that Cedrol significantly promoted hair growth in a dose-dependent manner, particularly for the female mice. Both male and female mice groups treated with 30mg/mL Cedrol required shorter time than the blank control and 2% minoxidil groups at different growth stages. Compared with the blank control (8.87mm) and 2% minoxidil (9.94mm) groups at 21days, the hair length of female mice treated with 30mg/mL Cedrol showed a remarkable increase with the value of 11.07mm. Hair in male and female mice groups treated with 30mg/mL Cedrol was heavier than the 2% minoxidil (38.2 and 35.9mg, respectively) groups with the weight of 42.6 and 45.2mg, respectively. Further observation of the hair follicle demonstrated that Cedrol exerted a remarkable effect on the hair follicle length.
    CONCLUSIONS:
    These findings suggested that Cedrol may be the main active ingredient of P. orientalis and have the potential of becoming a new hair growth promoter.
    Chamaejasmenin C

    Catalog No: CFN92061
    CAS No: 89595-70-0
    Price: $498/5mg
    Gomisin N

    Catalog No: CFN90125
    CAS No: 69176-52-9
    Price: $268/20mg
    Pd-C-II

    Catalog No: CFN95003
    CAS No: N/A
    Price: $358/5mg
    Ginsenoside Rg5

    Catalog No: CFN92643
    CAS No: 186763-78-0
    Price: $168/10mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $/mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg