Science | Nature | Cell | View More
Natural Products
Chamaejasmine
Chamaejasmine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chamaejasmine
Price: $463 / 5mg
CAS No.: 69618-96-8
Catalog No.: CFN92154
Molecular Formula: C30H22O10
Molecular Weight: 542.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Stellera chamaejasme Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $532.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Anna University (India)
  • Shanghai University of TCM (China)
  • University of Queensland (Australia)
  • University of Madras (India)
  • Universidad de La Salle (Mexico)
  • Medical University of Gdansk (Poland)
  • University of Parma (Italy)
  • Kyoto University (Japan)
  • VIB Department of Plant Systems... (Belgium)
  • University of Bonn (Germany)
  • More...
Package
Featured Products
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Ginsenoside Ro

Catalog No: CFN99147
CAS No: 34367-04-9
Price: $100/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Linolenic acid

Catalog No: CFN70110
CAS No: 463-40-1
Price: $30/20mg
Tamarixetin

Catalog No: CFN97027
CAS No: 603-61-2
Price: $ /
Ganoderic acid G

Catalog No: CFN90801
CAS No: 98665-22-6
Price: $318/20mg
Vincristine

Catalog No: CFN98589
CAS No: 57-22-7
Price: $138/20mg
Oxymatrine

Catalog No: CFN99805
CAS No: 16837-52-8
Price: $40/20mg
Licoricesaponin H2

Catalog No: CFN95173
CAS No: 118441-85-3
Price: $218/10mg
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate the outer mitochondrial membrane and causes cytochrome c release.
Targets: Bcl-2/Bax | Caspase | p53 | p21 | NF-kB | IkB | CDK | Akt | GSK-3 | PARP | ROS | P450 (e.g. CYP17) | IKK
In vitro:
Tumour Biol. 2015 Jul;36(7):5433-9.
Apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway.[Pubmed: 25677904 ]
Osteosarcoma cancer is one of the most lethal malignancies, and there is no effective preventive measure to date. Chamaejasmine is the major ingredient in Stellera chamaejasme L. Except its potent pain-relieving efficacy as reported, Chamaejasmine also exerted its anti-tumor activity in several tumor models.
METHODS AND RESULTS:
Here, we reported that Chamaejasmine had a profound anti-proliferative effect on human osteosarcoma cells in a concentration-dependent and time-dependent manner, which was associated with an increase of p21 and bax and a decrease of bcl-2 and consequently increased caspase-3 activity. The main mechanism of anti-tumor potency was mainly attributed to the induction of p53. Chamaejasmine hugely elevated the expression of p53. The results of p53 shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to Chamaejasmine, implicating the important role of p53 played in Chamaejasmine's anti-tumor activity.
CONCLUSIONS:
In conclusion, results showed Chamaejasmine induced apoptosis in MG63 cells and could be a candidate drug for osteosarcoma cancer chemoprevention.
Molecules. 2013 Jan 11;18(1):845-58.
Chamaejasmine arrests cell cycle, induces apoptosis and inhibits nuclear NF-κB translocation in the human breast cancer cell line MDA-MB-231.[Pubmed: 23344197]
In this study, the anticancer activity of Chamaejasmine was characterized in the human breast cancer cell line, MDA-MB-231.
METHODS AND RESULTS:
Cell viability and cell cycle distribution were determined by MTT assay and flow cytometry, respectively. Western blotting was performed to determine changes in levels of various proteins. Results showed that treatment with Chamaejasmine (4-16 μM) inhibited cell proliferation, which correlated with G2/M phase arrest and apoptosis in MDA-MB-231 cells. Chamaejasmine treatment of MDA-MB-231 cells resulted in induction of WAF1/p21 and KIP1/p27, decrease in cyclins A and cyclins B1. Cyclin-dependent kinase (cdk) 2 and cdc2 was also decreased after Chamaejasmine treatment. Moreover, inhibition of nuclear translocation, phosphorylation of NF-κB, activation of IKKα and IKKβ, inhibition of phosphorylation and degradation of IκBα were also detected in this work.
CONCLUSIONS:
Our findings suggested that Chamaejasmine could be explored as a preventive and perhaps as a chemotherapeutic agent in the management of breast cancer.
Chamaejasmine Description
Source: The roots of Stellera chamaejasme Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3'-Hydroxy-2,4,5-trimethoxydalberg...

Catalog No: CFN95410
CAS No: N/A
Price: $413/5mg
Somnifericin

Catalog No: CFN95280
CAS No: 173693-57-7
Price: $318/5mg
Tectoruside

Catalog No: CFN95051
CAS No: 38784-73-5
Price: $288/20mg
Margaritene

Catalog No: CFN95303
CAS No: 64271-10-9
Price: $318/10mg
Theaflavanoside II

Catalog No: CFN95380
CAS No: 943785-09-9
Price: $318/5mg
Epischisandrone

Catalog No: CFN95212
CAS No: 98619-26-2
Price: $413/5mg
Dioscoreside E

Catalog No: CFN95346
CAS No: 435321-73-6
Price: $318/5mg
Barbaloin-related compound A

Catalog No: CFN95453
CAS No: 473225-21-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Molecules. 2011 Sep 27;16(10):8152-64.
Chamaejasmine inactivates Akt to trigger apoptosis in human HEp-2 larynx carcinoma cells.[Pubmed: 21952497]
In the present study, we investigated the mechanisms of Chamaejasmine action on human HEp-2 larynx carcinoma cells, which possess constitutively active Akt.
METHODS AND RESULTS:
Results indicated that Chamaejasmine showed more notable anticancer activity than apigenin against HEp-2, PC-3, NCI-H1975, HT-29 and SKOV-3. Moreover, Chamaejasmine presented most significantly inhibition towards HEp-2, with IC₅₀ values of 1.92 µM. Treatment of HEp-2 cells with Chamaejasmine (1-4 μM) resulted in significant dose-dependent decrease in Akt phosphorylation at Serine473. Chamaejasmine-mediated dephosphorylation of Akt resulted in inhibition of its kinase activity, which was confirmed by reduced phosphorylation of proapoptotic proteins BAD and glycogen synthase kinase-3, essential downstream targets of Akt. Inactivation of Akt seems to be associated with downregulation of insulin-like growth factor receptor 1 protein level and inhibition of its autophosphorylation upon Chamaejasmine treatment. Exposure to Chamaejasmine significantly induced caspase-9 and caspase-3 activity. In vivo, Chamaejasmine intake through gavage resulted in inactivation of Akt and induction of apoptosis in HEp-2 tumors.
CONCLUSIONS:
These results suggest that Akt inactivation and dephosphorylation of BAD is a critical event, at least in part, in Chamaejasmine-induced HEp-2 cells apoptosis.
Molecules. 2011 Sep 27;16(10):8165-80.
Chamaejasmine induces apoptosis in human lung adenocarcinoma A549 cells through a Ros-mediated mitochondrial pathway.[Pubmed: 21952498 ]
In the present study, the anticancer activity of Chamaejasmine towards A549 human lung adenocarcinoma cells was investigated.
METHODS AND RESULTS:
In order to explore the underlying mechanism of cell growth inhibition of Chamaejasmine, cell cycle distribution, ROS generation, mitochondrial membrane potential (Δψ(m)) disruption, and expression of cytochrome c, Bax, Bcl-2, caspase-3, caspase-9 and PARP were measured in A549 cells. Chamaejasmine inhibited the growth of A549 cells in a time and dose-dependent manner. The IC₅₀ value was 7.72 µM after 72 h treatment. Chamaejasmine arrested the cell cycle in the G2/M phase and induced apoptosis via a ROS-mediated mitochondria-dependent pathway. Western blot analysis showed that Chamaejasmine inhibited Bcl-2 expression and induced Bax expression to desintegrate the outer mitochondrial membrane and causing cytochrome c release. Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascade, and active-caspase-3 was involved in PARP cleavage.
CONCLUSIONS:
All of these signal transduction pathways are involved in initiating apoptosis. To the best of our knowledge, this is the first report demonstrating the cytotoxic activity of Chamaejasmine towards A549 in vitro.
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Ginsenoside Ro

Catalog No: CFN99147
CAS No: 34367-04-9
Price: $100/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Linolenic acid

Catalog No: CFN70110
CAS No: 463-40-1
Price: $30/20mg
Tamarixetin

Catalog No: CFN97027
CAS No: 603-61-2
Price: $ /
Ganoderic acid G

Catalog No: CFN90801
CAS No: 98665-22-6
Price: $318/20mg
Vincristine

Catalog No: CFN98589
CAS No: 57-22-7
Price: $138/20mg
Oxymatrine

Catalog No: CFN99805
CAS No: 16837-52-8
Price: $40/20mg
Licoricesaponin H2

Catalog No: CFN95173
CAS No: 118441-85-3
Price: $218/10mg
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Tags: buy Chamaejasmine | Chamaejasmine supplier | purchase Chamaejasmine | Chamaejasmine cost | Chamaejasmine manufacturer | order Chamaejasmine | Chamaejasmine distributor