ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $187.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Nat Prod Sci.2016, 22(2)Food Sci Biotechnol....2016...Phytother Res.2016, 30(12):2020-2026Universidade Estadual Paulista...2017...Universidade Estadual Paulista...2017...Malaysian J of Fundamental and Ap...2018...Korean Journal of Medicinal Crop ...2018...Eur J Pharmacol.2018, 832:96-103
Bio-protocol2018, 9(14):e3301BMC Complement Altern Med....2019...Molecules.2019, 24(6):E1155Int J Mol Med.2019, 43(6):2516-2522Phytomedicine.2019, 55:229-237Pest Manag Sci.2019, 75(9):2530-2541Planta Med.2019, 85(9-10):766-773Process Biochemistry2019, 87:213-220
Sci Rep.2020, 10:4495(2020)BMC Complement Med Ther. ...2020...J Insect Sci.2020, 20(5):18. J Vet Sci.2020, 21(3):e39.Int J Mol Sci.2020, 21(9):3239.Molecules.2020, 25(18),4089.J of Applied Biological Chem....2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Toronto (Canada)University of Leipzig (Germany)Universidad de Ciencias y Artes... (Mexico)University of Minnesota (USA)
Amity University (India)Kyoto University (Japan)Aarhus University (Denmark)Technical University of Denmark (Denmark)
Institute of Tropical Disease U... (Indonesia)Medical University of Gdansk (Poland)Chulalongkorn University (Thailand)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Phytochem Anal.2016, 27(5):296-303Biochem Pharmacol.2017, 130:10-20Sci Rep. 2017, 17332(7)Ann Transl Med.2019, 7(23):731J Asian Nat Prod Res.2019, 5:1-17RSC Adv.2018, 32621-32636J Adv Res.2019, 17:85-94Food Chem.2020, 332:127412PLoS One.2018, 13(4):e0195642BMC Complement Altern Med.2014, 14:242
Related Screening Libraries
||β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50) value of 1.2x10(-4) M; it also exhibits weak cytotoxicity towards MCF-7 cells(IC50=30.50 uM). |
||NO | PGE | NOS | COX | EGFR | PAFR|
|Planta Med. 2014 Jun;80(8-9):655-61. |
|Inhibitory effects of β-chamigrenal, isolated from the fruits of Schisandra chinensis, on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages.[Pubmed: 24871206 ]|
Much is known about the bioactive properties of lignans from the fruits of Schisandra chinensis. However, very little work has been done to determine the properties of sesquiterpenes in the fruits of S. chinensis.
METHODS AND RESULTS:
The aim of the present study was to investigate the anti-inflammatory potential of new sesquiterpenes (β-Chamigrenal, β-chamigrenic acid, α-ylangenol, and α-ylangenyl acetate) isolated from the fruits of S. chinensis and to explore their effect on macrophages stimulated with lipopolysaccharide. Of these four sesquiterpenes, β-Chamigrenal most significantly suppressed lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages (47.21 ± 4.54 % and 51.61 ± 3.95 % at 50 μM, respectively). Molecularly, the inhibitory activity of β-Chamigrenal on nitric oxide production was mediated by suppressing inducible nitric oxide synthase activity but not its expression. In the prostaglandin E2 synthesis pathway, β-Chamigrenal prevented the upregulation of inducible microsomal prostaglandin E synthase-1 expression after stimulation with lipopolysaccharide. Conversely, β-Chamigrenal had no effect on the expression and enzyme activity of cyclooxygenase-2. In addition, the expression of early growth response factor-1, a key transcription factor of microsomal prostaglandin E synthase-1 expression, was inhibited by β-Chamigrenal.
These results may suggest a possible anti-inflammatory activity of β-Chamigrenal which has to be proven in in vivo experiments.
|Arch Pharm Res. 1997 Dec;20(6):633-6. |
|Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.[Pubmed: 18982271 ]|
|In the course of searching for PAF receptor antagonists, pregomisin (1) and Chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. |
METHODS AND RESULTS:
Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
||The fruits of Schisandra chinensis.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Korean Journal of Food Science & Technology, 2014, 46(6):665-670. |
|The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis.[Reference: WebLink]|
|We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract.
METHODS AND RESULTS:
Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) Chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (-)-gomisin L2, (11) schisandronic acid, (12) (-)-gomisin L1, (13) (+)-gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 μM, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 μM). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 μM).