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    Natural Products
    Cimidahurinine
    Information
    CAS No. 142542-89-0 Price
    Catalog No.CFN99465Purity>=98%
    Molecular Weight316.3 Type of CompoundPhenols
    FormulaC14H20O8Physical DescriptionOil
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Illinois (USA)
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    Cimidahurinine

    Cimidahurinine
    Product Name Cimidahurinine
    CAS No.: 142542-89-0
    Catalog No.: CFN99465
    Molecular Formula: C14H20O8
    Molecular Weight: 316.3 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Oil
    Targets: ROS | Bcl-2/Bax
    Source: The roots of Cimicifuga foetida
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • J Mol Med (Berl).2018, 96(7):661-672
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Drug Chem Toxicol.2020, 1-12.
  • Universite de Bordeaux2017, 2017BORD0867
  • BMC Complement Altern Med.2016, 16:213
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Molecules. 2013, 18(7):7376-88
  • Korean Journal of Pharmacognosy2014, 113-120
  • Food Chem.2017, 221:1135-1144
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cardioprotective Compound Library
  • Phenols Compound Library
  • ROS Inhibitor Library
  • Bcl-2/Bax Inhibitor Library
  • Biological Activity
    Description: Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins.
    Targets: ROS | Bcl-2/Bax
    In vitro:
    Food Chem. 2014 Dec 1;164:150-7.
    Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour.[Pubmed: 24996318]

    METHODS AND RESULTS:
    A total of 11 phenolic compounds, as well as sucrose (12) and tryptophan (13), were isolated from cold-pressed Perilla frutescens var. arguta seed flour using column chromatography, and their chemical structures were identified as 3'-dehydroxyl-rosmarinic acid-3-o-glucoside (1), rosmarinic acid-3-o-glucoside (2), rosmarinic acid (3), rosmarinic acid methyl ester (4), luteolin (5), luteolin-5-o-glucoside (6), apigenin (7), caffeic acid (8), caffeic acid-3-o-glucoside (9), vanillic acid (10) and Cimidahurinine (11) using NMR and time-of-flight mass spectrometry.
    CONCLUSIONS:
    Of these components, compound 1 is novel, and this is the first report of compounds 10 and 11 in perilla seeds. HPLC quantification combined with antioxidant activity evaluation revealed that rosmarinic acid and rosmarinic acid-3-o-glucoside were the dominant phenolic antioxidants with strong antioxidant activities.
    J Asian Nat Prod Res. 2005 Oct;7(5):695-9.
    Triterpenoid glycoside from Cimicifuga racemosa.[Pubmed: 16176901]

    METHODS AND RESULTS:
    One new triterpene glycoside, cimiracemoside (I), and 14 known triterpene glycosides have been isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). On the basis of spectral and chemical evidence, the structure of the new compound was elucidated to be 12β-acetoxycimigenol-3-O-β-d-xylopranoside (1), and the known compounds were identified to be 25—acetylcimigenol xyloside (2), cimigenol-3-O-β-d-xylopyranoside (3), acetin (4), 27-deoxyacetin (5), cimicifugoside H-1 (6), 23-O-acetylshengmanol 3-O-β-d-xylopranoside (7), foetidinol-3-O-β-xyloside (8), cimicifugoside H-2 (9), 25-O-methylcimigenol xyloside (10), 21-hydroxycimigenol-3-O-β-d-xylopyranoside (11), 24-epi-7,8—didehydrocimigenol-3-xyloside (12), Cimidahurinine (13), cimidahurine (14) and cimifugin (15).
    CONCLUSIONS:
    The compounds 1–5, 14, and 15 showed weak antibacterial activities in the agar diffusion assay.
    Rsc Adv., 2015, 5(129):106431-8.
    A dual-fluorescent whole-well imaging approach for screening active compounds against doxorubicin-induced cardiotoxicity from natural products[Reference: WebLink]
    Doxorubicin (DOX) is an effective chemotherapy drug for various types of cancer. However, acute and chronic cardiotoxicity of DOX hamper its clinical application. There is a great demand for the discovery of drugs against DOX-induced cardiotoxicity. This paper proposed a dual fluorescence cellular imaging assay for screening active compounds against DOX toxicity.
    METHODS AND RESULTS:
    Whole-well fluorescence images of cells in 96-well microplates were automatically acquired and reconstructed by using a fluorescence microscope coupled with a computer-controlled moving stage. DOX-injured cardiomyocytes were labeled with two fluorescent probes, namely, fluorescein diacetate and Hoechst 33342, to determine cell viability and apoptosis. The linear range and sensitivity of the proposed approach were evaluated and validated by a known active compound, rutin. The proposed approach was also successfully applied in screening active compounds from a clinically used herbal medicine ZhenQiFuZheng granule (ZQFZ), which consisted of two herbs, Astragalus membranaceus (Fisch.) Bunge and Ligustrum lucidum. Five active components were found and were further analyzed by liquid chromatography coupled with mass spectrometry. Hydroxytyrosol, neonuezhenide, salidroside, and Cimidahurinine attenuated DOX-induced cardiotoxicity in a dose-dependent manner with EC50 values of 198.0, 260.4, 621.7, and 45.79 μM, respectively.
    CONCLUSIONS:
    Western blot results indicated that these active compounds protected against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins. The proposed approach is efficient in screening active compounds from natural products and other complex mixtures.
    Cimidahurinine Description
    Source: The roots of Cimicifuga foetida
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1616 mL 15.8078 mL 31.6156 mL 63.2311 mL 79.0389 mL
    5 mM 0.6323 mL 3.1616 mL 6.3231 mL 12.6462 mL 15.8078 mL
    10 mM 0.3162 mL 1.5808 mL 3.1616 mL 6.3231 mL 7.9039 mL
    50 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.2646 mL 1.5808 mL
    100 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(7):861-4.
    [Chemical constituents from fruits of Ligustrum lucidum].[Pubmed: 20575386]
    To study the chemical constituents from the fruits of Ligustrum lucidum.
    METHODS AND RESULTS:
    The chemical constituents from the ethanol extract of L. lucidum were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatographic methods. Their structures were identified on the basis of spectroscopic data and physico-chemical properties. Twenty compounds were isolated and identified as oleanolic acid (1), crategolic acid (2), acetyl oleanolic acid (3), lupeol (4), betulin (5), dammarenediol-II (6), 3beta-acetyl-20, 25-epoxydammarane-24alpha-ol (7), 25-epoxydammarane-3beta, 24alpha-diol (8), dammar-24-ene-3beta-acetyl-20S-ol) (9), 20S, 24R-dammarane-25-ene-24-hydroperoxy-3beta, 20-diol (10), fouquierol (11), oliganthas A (12), dammarenediol II 3-O-palmitate (13), ocotillol II 3-O-palmitate (14), (E) -25-hydroperoxydammar-23-ene-3beta,20-diol (15), verbascoside (16), Cimidahurinine (17), 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (18), osmanthuside H (19), 2-(3,4-dihydroxyphenyl) ethanol (20).
    CONCLUSIONS:
    Compounds 4, 16,17, 19 were isolated from this plant for the first time, andcompounds 12-15 were isolated from this genus for the first time.
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