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    Natural Products
    Convolvine
    Convolvine
    Information
    CAS No. 537-30-4 Price
    Catalog No.CFN00186Purity>=98%
    Molecular Weight291.34Type of CompoundAlkaloids
    FormulaC16H21NO4Physical DescriptionOil
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Convolvine

    Convolvine
    Product Name Convolvine
    CAS No.: 537-30-4
    Catalog No.: CFN00186
    Molecular Formula: C16H21NO4
    Molecular Weight: 291.34 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Oil
    Targets: Immunology & Inflammation related
    Source: The herbs of genus Convolvulus.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • J Ethnopharmacol.2017, 206:73-77
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Convolvine and its derivatives exhibit pronounced antihypoxic, immunomodulating, and anti-inflammatory activity, they exhibit cytotoxic activity, the alkaloids N-benzylconvolvine and N-chloroacetylconvolvine at concentrations of 10 ug/mL exhibit the greatest activity against HeLa and Hep cancer cell cultures. Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS,convolvine has revealed characteristics of a sedative and nootropic agent.
    Targets: Immunology & Inflammation related
    In vitro:
    Chemistry of Natural Compounds,2011,47(4): 608-11.
    Derivatives of the alkaloid convolvine and their pharmacological activity[Reference: WebLink]

    METHODS AND RESULTS:
    The alkaloid contents of Convolvulus subhirsutus and C. pseudocanthabrica growing in various regions of Uzbekistan, Kazakhstan, and Tadzhikistan were previously investigated and were found to include ~10 tropane alkaloids [ 1 , 2 ]. The alkaloid composition and content depended on the habitat. Thus, total alkaloids in C. subhirsutus growing in Uzbekistan was 0.6–0.75% (aerial part) and 0.6–1.6% (roots) [ 2 , 3 ]; in Tadzhikistan, 0.12%(aerial part) [ 4 ]. The main alkaloids in all plants were nortropine derivatives Convolvine ( 1 , 3,4-dimethoxybenzoyloxynortropane) and Convolamine (3,4-dimethoxybenzoyloxytropane), which amounted to 40–50% of the total. The alkylation and acylation of the NH group in 1 were studied [ 3 ].
    CONCLUSIONS:
    Preliminary tests showed that the synthesized compounds included some with pronounced antihypoxic, immunomodulating, and anti-inflammatory activity.
    Chemistry of Natural Compounds, 2013,48(6):1039-41.
    Synthesis of convolinine and cytotoxic activity of alkaloids of the genus Convolvulus and their derivatives[Reference: WebLink]
    The minor base convolinine was synthesized.
    METHODS AND RESULTS:
    The activity of alkaloids from plants of the genus Convolvulus and their derivatives against HeLa and Hep cancer cell cultures and primary fibroblast culture was studied. It was found that the alkaloid Convolvine and its derivatives exhibited cytotoxic activity.
    CONCLUSIONS:
    The alkaloids N-benzylConvolvine (4) and N-chloroacetylConvolvine (5) at concentrations of 10 μg/mL exhibited the greatest activity against HeLa and Hep cancer cell cultures. The percent suppression of HeLa cervical carcinoma cells by alkaloid 4 was 35%; of Hep laryngeal cancer cells, 81.6%.
    In vivo:
    Chemistry of Natural Compounds,1998,34(1):56-8.
    Neuro- and psychopharmacological investigation of the alkaloids convolvine and atropine[Reference: WebLink]
    It has been established that Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS, while atropine blocks all the abovementioned M-receptors.
    METHODS AND RESULTS:
    Convolvine has revealed characteristics of a sedative and nootropic agent. Atropine, however, which is known as a psychomotor stimulator, prevents the realization of a conditioned gastromotor reflex. An analysis has been made of the relationship between features of the pharmacological activities and chemical structures of Convolvine and atropine.
    Convolvine Description
    Source: The herbs of genus Convolvulus.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4324 mL 17.1621 mL 34.3242 mL 68.6483 mL 85.8104 mL
    5 mM 0.6865 mL 3.4324 mL 6.8648 mL 13.7297 mL 17.1621 mL
    10 mM 0.3432 mL 1.7162 mL 3.4324 mL 6.8648 mL 8.581 mL
    50 mM 0.0686 mL 0.3432 mL 0.6865 mL 1.373 mL 1.7162 mL
    100 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.6865 mL 0.8581 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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