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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
BMC Complement Altern Med....2019...Separations2021, 8(1), 1.Srinagarind Medical Journal2017, 32(1)Sci Rep.2017, 7:40345Bull. Pharm. Sci., Assiut Univers...2020...Journal of Oil Palm Research...2019...Phytochem Anal.2021, 32(6):970-981.mBio.2020, 11(3):e00686-20.
J Nat Prod.2019, 82(4):1002-1008J Chromatogr B Analyt Technol Bio...2019...Antioxidants (Basel).2021, 10(10):1620.Pharmacol Rep.2017, 69(6):1224-1231Crystals2020, 10(3), 206.J of Pharmaceutical Analysis...2020...Chinese Journal of Hospital Pharm...2020...Food Chem.2019, 275:746-753
BMB Rep.2020, 53(4):218-222.Molecules.2021, 26(6):1738. J Nat Med.2018, 72(3):734-744Int J Mol Sci.2019, 20(3):E651Phytother Res.2018, 32(12):2551-2559J Ethnopharmacol.2017, 197:157-164Phytochemistry2018, 15:83-92
Our products had been exported to the following research institutions and universities, And still growing.
University Medical Center Mainz (Germany)University of Melbourne (Australia)University of Dicle (Turkey)Osmania University (India)
University of Leipzig (Germany)Periyar University (India)Uniwersytet Gdański (Poland)University of Pretoria (South Africa)
Johannes Gutenberg University M... (Germany)CSIRO - Agriculture Flagship (Australia)Celltrion Chemical Research Ins... (Korea)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Ethnopharmacol.2017, 206:73-77Asian Journal of Chemistry2014, 26(22):7811-7816Food Res Int.2021, 148:110607.Curr Top Med Chem.2020, 20(21):1898-1909.Plants2022, 11(3),294.LWT2021, 147:111620.Int J Mol Sci.2021, 22(19):10220.J Clin Med.2019, 8(10):E1664J Ethnopharmacol.2022, 289:115018. Srinagarind Medical Journal2019, 34(1)
Related Screening Libraries
||Convolvine and its derivatives exhibit pronounced antihypoxic, immunomodulating, and anti-inflammatory activity, they exhibit cytotoxic activity, the alkaloids N-benzylconvolvine and N-chloroacetylconvolvine at concentrations of 10 ug/mL exhibit the greatest activity against HeLa and Hep cancer cell cultures. Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS,convolvine has revealed characteristics of a sedative and nootropic agent.|
||Immunology & Inflammation related|
|Chemistry of Natural Compounds,2011,47(4): 608-11. |
|Derivatives of the alkaloid convolvine and their pharmacological activity[Reference: WebLink]|
METHODS AND RESULTS:
The alkaloid contents of Convolvulus subhirsutus and C. pseudocanthabrica growing in various regions of Uzbekistan, Kazakhstan, and Tadzhikistan were previously investigated and were found to include ~10 tropane alkaloids [ 1 , 2 ]. The alkaloid composition and content depended on the habitat. Thus, total alkaloids in C. subhirsutus growing in Uzbekistan was 0.6–0.75% (aerial part) and 0.6–1.6% (roots) [ 2 , 3 ]; in Tadzhikistan, 0.12%(aerial part) [ 4 ]. The main alkaloids in all plants were nortropine derivatives Convolvine ( 1 , 3,4-dimethoxybenzoyloxynortropane) and Convolamine (3,4-dimethoxybenzoyloxytropane), which amounted to 40–50% of the total. The alkylation and acylation of the NH group in 1 were studied [ 3 ].
Preliminary tests showed that the synthesized compounds included some with pronounced antihypoxic, immunomodulating, and anti-inflammatory activity.
|Chemistry of Natural Compounds, 2013,48(6):1039-41. |
|Synthesis of convolinine and cytotoxic activity of alkaloids of the genus Convolvulus and their derivatives[Reference: WebLink]|
|The minor base convolinine was synthesized.
METHODS AND RESULTS:
The activity of alkaloids from plants of the genus Convolvulus and their derivatives against HeLa and Hep cancer cell cultures and primary fibroblast culture was studied. It was found that the alkaloid Convolvine and its derivatives exhibited cytotoxic activity.
The alkaloids N-benzylConvolvine (4) and N-chloroacetylConvolvine (5) at concentrations of 10 μg/mL exhibited the greatest activity against HeLa and Hep cancer cell cultures. The percent suppression of HeLa cervical carcinoma cells by alkaloid 4 was 35%; of Hep laryngeal cancer cells, 81.6%.
|Chemistry of Natural Compounds,1998,34(1):56-8. |
|Neuro- and psychopharmacological investigation of the alkaloids convolvine and atropine[Reference: WebLink]|
|It has been established that Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS, while atropine blocks all the abovementioned M-receptors.
METHODS AND RESULTS:
Convolvine has revealed characteristics of a sedative and nootropic agent. Atropine, however, which is known as a psychomotor stimulator, prevents the realization of a conditioned gastromotor reflex. An analysis has been made of the relationship between features of the pharmacological activities and chemical structures of Convolvine and atropine.
||The herbs of genus Convolvulus.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.