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    Natural Products
    Coptisine chloride
    Information
    CAS No. 6020-18-4 Price $128 / 20mg
    Catalog No.CFN99564Purity>=98%
    Molecular Weight355.77Type of CompoundAlkaloids
    FormulaC19H14NO4ClPhysical DescriptionPowder
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    Size /Price /Stock 10 mM * 1 mL in DMSO / $46.0 / In-stock
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    Coptisine chloride

    Coptisine chloride
    Product Name Coptisine chloride
    CAS No.: 6020-18-4
    Catalog No.: CFN99564
    Molecular Formula: C19H14NO4Cl
    Molecular Weight: 355.77 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The herbs of Chelidonium majus L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $128 / 20mg
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  • J. of The Korean Society of Food Culture2017, 144-149
  • Int J Mol Sci.2017, 19(1)
  • The Journal of Phytopharmacology2020, 9(1): 1-4
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  • Eur Endod J.2020, 5(1):23-27.
  • Planta Med.2018, 84(15):1101-1109
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  • Front Pharmacol.2016, 7:460
  • Chinese Medicine2019, 14(1)
  • Inflammation.2020, 43(5):1716-1728.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Coptisine is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2523-7.
    [Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers].[Pubmed: 18330249 ]
    To study the absorption of Coptisine chloride (COP) and berberrubine (BRB) as chemical constituents of some traditional Chinese medicines in human intestinal epithelial.
    METHODS AND RESULTS:
    By using Caco-2 (the human colonic adenocarcinoma cell lines) cell monolayers as an intestinal epithelial cell model, the permeability of Coptisine chloride and BRB were studied from apical side (AP side) to basolateral side (BL side) or from BL side to AP side. The two alkaloids were measured by reversed-phase high performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (P(app)) were then calculated and compared with those of propranolol and atenolol. P(app) values were also compared with the reported values for model compounds (propranolol and atenolol). The P(app) values of Coptisine chloride, BRB were (1.103 +/- 0.162) x 10(-5), (1.309 +/- 0.102) x 10(-5) cm x s(-1 from AP side to BL side, and (0.300 +/- 0.041) x 10(-5) and (1.955 +/- 0.055) x 10(-5) cm x s(-1) from BL side to AP side, respectively. Their P(app) values were identical with those of propranolol [(2.23 +/- 0.10) x 10(-5 cm x s(-1)], which is a transcellular transport marker and as a control substance for high permeability. On the other hand, the efflux transport of BRB was higher 1.49 times more than its influx transport with 0.67 rate of P(app A-->B)/P(app B-->A). But P(app A-->B)/P(app B-->A value of Coptisine chloride was 3.67, which suggested that the efflux transport have not been involved in its absorbed mechanism in Caco-2 cells monolayers.
    CONCLUSIONS:
    Coptisine chloride and BRB can be absorbed across intestinal epithelial cells, and they are completely absorbed compounds. BRB may have been involved in efflux mechanism in Caco-2 cells monolayers model from the basolateral-to-apical direction.
    Coptisine chloride Description
    Source: The herbs of Chelidonium majus L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8108 mL 14.054 mL 28.108 mL 56.2161 mL 70.2701 mL
    5 mM 0.5622 mL 2.8108 mL 5.6216 mL 11.2432 mL 14.054 mL
    10 mM 0.2811 mL 1.4054 mL 2.8108 mL 5.6216 mL 7.027 mL
    50 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.1243 mL 1.4054 mL
    100 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.5622 mL 0.7027 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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