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Cyclo(Phe-Leu)
Cyclo(Phe-Leu)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Phe-Leu)
Price: $238 / 10mg
CAS No.: 3354-31-2
Catalog No.: CFN90273
Molecular Formula: C15H20N2O2
Molecular Weight: 260.34 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Rubia schumanniana Pritzel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Phe-Leu) is a new cell cycle inhibitor.
In vitro:
Journal of Shenyang Pharmaceutical University, 2015 (2):107 -10.
Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522[Reference: WebLink]
To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),Cyclo(Ile-Ala)(2),cyclo(Ala-Val)(3),Cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and cyclo(Phe-Val)(6).Conclusions Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
Cyclo(Phe-Leu) Description
Source: The roots of Rubia schumanniana Pritzel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8411 mL 19.2057 mL 38.4113 mL 76.8226 mL 96.0283 mL
5 mM 0.7682 mL 3.8411 mL 7.6823 mL 15.3645 mL 19.2057 mL
10 mM 0.3841 mL 1.9206 mL 3.8411 mL 7.6823 mL 9.6028 mL
50 mM 0.0768 mL 0.3841 mL 0.7682 mL 1.5365 mL 1.9206 mL
100 mM 0.0384 mL 0.1921 mL 0.3841 mL 0.7682 mL 0.9603 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Chem Biol. 2009 Jun;5(6):414-20.
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.[Pubmed: 19430487]

METHODS AND RESULTS:
In this pathway, the formation of the Cyclo(Phe-Leu) (2) intermediate is catalyzed by AlbC, a small protein unrelated to NRPSs. We demonstrated that AlbC uses aminoacyl-tRNAs as substrates to catalyze the formation of the DKP peptide bonds. Moreover, several other bacterial proteins, presenting moderate similarity to AlbC, also use aminoacyl-tRNAs to synthesize various cyclodipeptides.
CONCLUSIONS:
Therefore, AlbC and these related proteins belong to a newly defined family of enzymes that we have named cyclodipeptide synthases (CDPSs).
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